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MeSH Review


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Disease relevance of Amblyopia


Psychiatry related information on Amblyopia


High impact information on Amblyopia

  • Whereas strabismus or amblyopia disrupted the normal excitatory interactions between the two eyes, cortical inhibitory binocular connections seem not to have been disrupted [10].
  • Atropine vs patching for treatment of amblyopia in children [11].
  • Studies of local cerebral blood flow and glucose metabolism as indicators of brain function in amblyopia are reviewed [12].
  • METHOD: Contour-detection thresholds and optotype acuity were measured in 17 newly diagnosed anisometropic amblyopes, in 6 patients with strabismic amblyopia, and in 4 patients with combined anisometropic and strabismic amblyopia [13].
  • Levodopa/carbidopa for childhood amblyopia [14].

Chemical compound and disease context of Amblyopia

  • This paper reviews reports of a strikingly similar epidemic known as the "Amblyopia of the Blockade," which occurred in Cuba almost a century ago when the island was undergoing a US naval blockade during the Cuban-Spanish-American war [15].
  • Use of the PVEP with chloral hydrate sedation may prove clinically useful for detecting amblyopia in uncooperative infants and children [16].
  • The overall incidence of adverse events was similar for both treatment groups, except for a significantly greater incidence of amblyopia in patients receiving buspirone 15 mg BID [17].
  • There appears to be no direct relationship between the expression of NMDA-R1 receptors and the level of excitability, binocularity or neuronal acuity known to exist in either of these two cat models of amblyopia, thus raising further questions as to the precise nature of the role of NMDA receptors in the processes of visual cortical plasticity [18].
  • OBJECTIVE: To compare patching and atropine sulfate as treatments for moderate amblyopia in children 18 months after completion of a 6-month randomized trial [19].

Biological context of Amblyopia


Anatomical context of Amblyopia


Gene context of Amblyopia


Analytical, diagnostic and therapeutic context of Amblyopia


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  2. Blindness in the Indian state of Andhra Pradesh. Dandona, L., Dandona, R., Srinivas, M., Giridhar, P., Vilas, K., Prasad, M.N., John, R.K., McCarty, C.A., Rao, G.N. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  3. Visual acuities and scotomas after one week levodopa administration in human amblyopia. Gottlob, I., Charlier, J., Reinecke, R.D. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  4. Expression of folate receptor alpha in the mammalian retinol pigmented epithelium and retina. Smith, S.B., Kekuda, R., Gu, X., Chancy, C., Conway, S.J., Ganapathy, V. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  5. Baltimore Vision Screening Project. Preslan, M.W., Novak, A. Ophthalmology (1996) [Pubmed]
  6. Neurology of latent nystagmus. Gresty, M.A., Metcalfe, T., Timms, C., Elston, J., Lee, J., Liu, C. Brain (1992) [Pubmed]
  7. Strabismus, amblyopia, and dyslexia. Gitschlag, G., Scott, W.E. Prim. Care (1982) [Pubmed]
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  9. Effect of levodopa and carbidopa in human amblyopia. Pandey, P.K., Chaudhuri, Z., Kumar, M., Satyabala, K., Sharma, P. Journal of pediatric ophthalmology and strabismus. (2002) [Pubmed]
  10. Humans deprived of normal binocular vision have binocular interactions tuned to size and orientation. Levi, D.M., Harwerth, R.S., Smith, E.L. Science (1979) [Pubmed]
  11. Atropine vs patching for treatment of amblyopia in children. Kushner, B.J. JAMA (2002) [Pubmed]
  12. Positron emission tomographic studies of cortical function in human amblyopia. Demer, J.L. Neuroscience and biobehavioral reviews. (1993) [Pubmed]
  13. Recovery of contour integration in relation to LogMAR visual acuity during treatment of amblyopia in children. Chandna, A., Gonzalez-Martin, J.A., Norcia, A.M. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  14. Levodopa/carbidopa for childhood amblyopia. Leguire, L.E., Rogers, G.L., Bremer, D.L., Walson, P.D., McGregor, M.L. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  15. Cuban epidemic neuropathy, 1991 to 1994: history repeats itself a century after the "amblyopia of the blockade". Ordúñez-García, P.O., Nieto, F.J., Espinosa-Brito, A.D., Caballero, B. American journal of public health. (1996) [Pubmed]
  16. Recording pattern visual evoked potentials under chloral hydrate sedation. Wright, K.W., Eriksen, K.J., Shors, T.J., Ary, J.P. Arch. Ophthalmol. (1986) [Pubmed]
  17. Efficacy and safety of two dosing regimens of buspirone in the treatment of outpatients with persistent anxiety. Sramek, J.J., Frackiewicz, E.J., Cutler, N.R. Clinical therapeutics. (1997) [Pubmed]
  18. Distribution and localization of NMDA receptor subunit 1 in the visual cortex of strabismic and anisometropic amblyopic cats. Yin, Z.Q., Crewther, S.G., Yang, M., Crewther, D.P. Neuroreport (1996) [Pubmed]
  19. Two-year follow-up of a 6-month randomized trial of atropine vs patching for treatment of moderate amblyopia in children. Repka, M.X., Wallace, D.K., Beck, R.W., Kraker, R.T., Birch, E.E., Cotter, S.A., Donahue, S., Everett, D.F., Hertle, R.W., Holmes, J.M., Quinn, G.E., Scheiman, M.M., Weakley, D.R. Arch. Ophthalmol. (2005) [Pubmed]
  20. Abnormal saccadic substitution during small-amplitude pursuit tracking in amblyopic eyes. Ciuffreda, K.J., Kenyon, R.V., Stark, L. Invest. Ophthalmol. Vis. Sci. (1979) [Pubmed]
  21. Negative predictive value of a population-based preschool vision screening program. De Becker, I., MacPherson, H.J., LaRoche, G.R., Braunstein, J., Cottle, R., McIntyre, L.L., Kozousek, V. Ophthalmology (1992) [Pubmed]
  22. OKN asymmetries in orthoptic patients: contributing factors and effect of treatment. Westall, C.A., Shute, R.H. Behav. Brain Res. (1992) [Pubmed]
  23. Field expansion for homonymous hemianopia by optically induced peripheral exotropia. Peli, E. Optometry and vision science : official publication of the American Academy of Optometry. (2000) [Pubmed]
  24. Understanding the neural basis of amblyopia. Barrett, B.T., Bradley, A., McGraw, P.V. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. (2004) [Pubmed]
  25. Haphazard neural connections underlie the visual deficits of cats with strabismic or deprivation amblyopia. Gingras, G., Mitchell, D.E., Hess, R.F. Eur. J. Neurosci. (2005) [Pubmed]
  26. Unilateral peripapillary myelinated nerve fibers with myopia and/or amblyopia. Hittner, H.M., Antoszyk, J.H. Arch. Ophthalmol. (1987) [Pubmed]
  27. Paradoxic pupillary phenomena. A review of patients with pupillary constriction to darkness. Frank, J.W., Kushner, B.J., France, T.D. Arch. Ophthalmol. (1988) [Pubmed]
  28. Unilateral peripapillary myelinated retinal nerve fibers associated with strabismus, amblyopia, and myopia. Lee, M.S., Gonzalez, C. Am. J. Ophthalmol. (1998) [Pubmed]
  29. Characteristics of glucose metabolism in the visual cortex of amblyopes using positron-emission tomography and statistical parametric mapping. Choi, M.Y., Lee, D.S., Hwang, J.M., Choi, D.G., Lee, K.M., Park, K.H., Yu, Y.S. Journal of pediatric ophthalmology and strabismus. (2002) [Pubmed]
  30. Leber's hereditary optic neuropathy masquerading as tobacco-alcohol amblyopia. Cullom, M.E., Heher, K.L., Miller, N.R., Savino, P.J., Johns, D.R. Arch. Ophthalmol. (1993) [Pubmed]
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  33. The minimum occlusion trial for the treatment of amblyopia. Keech, R.V., Ottar, W., Zhang, L. Ophthalmology (2002) [Pubmed]
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  35. Functional MRI of amblyopia before and after levodopa. Yang, C.I., Yang, M.L., Huang, J.C., Wan, Y.L., Jui-Fang Tsai, R., Wai, Y.Y., Liu, H.L. Neurosci. Lett. (2003) [Pubmed]
  36. Results of pediatric laser in situ keratomileusis. Agarwal, A., Agarwal, A., Agarwal, T., Siraj, A.A., Narang, P., Narang, S. Journal of cataract and refractive surgery. (2000) [Pubmed]
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  38. Successful implementation of a protocol for photorefractive keratectomy in children requiring anesthesia. Paysse, E.A., Hussein, M.A., Koch, D.D., Wang, L., Brady McCreery, K.M., Glass, N.L., Hamill, M.B. Journal of cataract and refractive surgery. (2003) [Pubmed]
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