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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Physical Examination

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Disease relevance of Physical Examination


Psychiatry related information on Physical Examination

  • Predictor variables included all physical examination elements, measures of injury severity (initial Glasgow Coma Scale score, duration of post-traumatic amnesia [PTA], length of coma, CT scan pathology), gender, age, and years of education [6].
  • Chronic episodic disorders, such as depressive disorders, IBS, migraine, and FMS, have important commonalities, including cormorbidities, an absence of classic anatomic pathology in the tissues, a lack of objective findings on physical examination, and a lack of abnormal findings by routine laboratory and radiologic tests [7].

High impact information on Physical Examination


Chemical compound and disease context of Physical Examination


Biological context of Physical Examination


Anatomical context of Physical Examination


Associations of Physical Examination with chemical compounds

  • At each examination all members of the family gave a history and had a physical examination, urine analysis, and appropriate cultures; antistreptococcal antibody titres and serum C3 were determined [28].
  • Tools for diagnosis and management have not changed much in the past two decades, and include the clinical history, physical examination, tests for specific IgE antibody to suspected foods, elimination diets, oral food challenges, and provision of medications such as epinephrine for emergency treatment [29].
  • During a mean follow-up interval of 38 months, the degree and extent of skin thickness, determined on physical examination, decreased considerably more in the patients treated with D-penicillamine than in patients in the comparison group (p = 0.07) [30].
  • However, all the diagnostic studies used for assessing the liver, including physical examination, serum liver enzyme and bilirubin measurements, and radionuclide liver scan, were only moderately accurate [31].
  • In the 1,141 men with 3 serial physical examinations, who developed no diseases and who took no drugs known to affect uric acid levels, levels rose from means below 5.5 mg/dl in 1961--1963 to means above 6.5 mg/dl in 1975--1978 [32].

Gene context of Physical Examination

  • METHODS: We obtained detailed medical histories, did physical examinations, measured concentrations of lipoproteins, and harvested genomic DNA from 28 Sardinians with ARH from 17 unrelated families [33].
  • Physical examination of the IA-2(- /-) animals and histological examination of tissues failed to reveal any abnormalities [34].
  • Besides clearly defined NDI symptoms caused by deletion of the AVPR2 gene, no major morphological abnormalities as determined by physical examination, radiography, ultrasound, and computed tomographic scan were detected [35].
  • METHODS: Clinical and hormonal characterization included physical examination and measurement of GH, IGF-I, IGF binding protein-3 (IGFBP-3), cortisol, prolactin, LH, FSH, and free thyroxine (FT4) [36].
  • Standardized history and physical examination data were recorded, as were the results of serial blood sampling for S-Mgb, CA-III, and CK-MB at 0, 1, and 3 hours after patient presentation [37].

Analytical, diagnostic and therapeutic context of Physical Examination


  1. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. McKenzie, R., Fried, M.W., Sallie, R., Conjeevaram, H., Di Bisceglie, A.M., Park, Y., Savarese, B., Kleiner, D., Tsokos, M., Luciano, C. N. Engl. J. Med. (1995) [Pubmed]
  2. Kava-induced dermopathy: a niacin deficiency? Ruze, P. Lancet (1990) [Pubmed]
  3. Can moderate chronic obstructive pulmonary disease be diagnosed by historical and physical findings alone? Badgett, R.G., Tanaka, D.J., Hunt, D.K., Jelley, M.J., Feinberg, L.E., Steiner, J.F., Petty, T.L. Am. J. Med. (1993) [Pubmed]
  4. Additional evidence for lack of transmission of HIV infection by close interpersonal (casual) contact. Friedland, G., Kahl, P., Saltzman, B., Rogers, M., Feiner, C., Mayers, M., Schable, C., Klein, R.S. AIDS (1990) [Pubmed]
  5. Felty's syndrome without splenomegaly. Logue, G.L., Silberman, H.R. Am. J. Med. (1979) [Pubmed]
  6. Clinical elements that predict outcome after traumatic brain injury: a prospective multicenter recursive partitioning (decision-tree) analysis. Brown, A.W., Malec, J.F., McClelland, R.L., Diehl, N.N., Englander, J., Cifu, D.X. J. Neurotrauma (2005) [Pubmed]
  7. Chronic episodic disorders in women. Warnock, J.K., Clayton, A.H. Psychiatr. Clin. North Am. (2003) [Pubmed]
  8. The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. Michels, V.V., Moll, P.P., Miller, F.A., Tajik, A.J., Chu, J.S., Driscoll, D.J., Burnett, J.C., Rodeheffer, R.J., Chesebro, J.H., Tazelaar, H.D. N. Engl. J. Med. (1992) [Pubmed]
  9. Testicular function in boys after chemotherapy for acute lymphoblastic leukemia. Blatt, J., Poplack, D.G., Sherins, R.J. N. Engl. J. Med. (1981) [Pubmed]
  10. The rational clinical examination. Does this patient have carpal tunnel syndrome? D'Arcy, C.A., McGee, S. JAMA (2000) [Pubmed]
  11. Classification criteria for systemic lupus erythematosus. Frequency in normal patients. Wolf, L., Sheahan, M., McCormick, J., Michel, B., Moskowitz, R.W. JAMA (1976) [Pubmed]
  12. Predictors of treatment response to behavioral therapy and pharmacotherapy for urinary incontinence. Goode, P.S. Gastroenterology (2004) [Pubmed]
  13. Nefazodone versus sertraline in outpatients with major depression: focus on efficacy, tolerability, and effects on sexual function and satisfaction. Feiger, A., Kiev, A., Shrivastava, R.K., Wisselink, P.G., Wilcox, C.S. The Journal of clinical psychiatry. (1996) [Pubmed]
  14. Cerebrospinal fluid lactic acid levels in meningitis. Controni, G., Rodriguez, W.J., Hicks, J.M., Ficke, M., Ross, S., Friedman, G., Khan, W. J. Pediatr. (1977) [Pubmed]
  15. Emergency department diagnosis of ectopic pregnancy. Stovall, T.G., Kellerman, A.L., Ling, F.W., Buster, J.E. Annals of emergency medicine. (1990) [Pubmed]
  16. Identification of a single cytosine base insertion mutation at Arg-597 of the beta subunit of the human epithelial sodium channel in a family with Liddle's disease. Inoue, T., Okauchi, Y., Matsuzaki, Y., Kuwajima, K., Kondo, H., Horiuchi, N., Nakao, K., Iwata, M., Yokogoshi, Y., Shintani, Y., Bando, H., Saito, S. Eur. J. Endocrinol. (1998) [Pubmed]
  17. Differentiation of typhoid fever from fulminant hepatic failure in patients presenting with jaundice and encephalopathy. Kamath, P.S., Jalihal, A., Chakraborty, A. Mayo Clin. Proc. (2000) [Pubmed]
  18. Relation of acanthosis nigricans to hyperinsulinemia and insulin sensitivity in overweight African American and white children. Nguyen, T.T., Keil, M.F., Russell, D.L., Pathomvanich, A., Uwaifo, G.I., Sebring, N.G., Reynolds, J.C., Yanovski, J.A. J. Pediatr. (2001) [Pubmed]
  19. Postoperative screening of patients with carcinoma of the colon. Beart, R.W., Metzger, P.P., O'Connell, M.J., Schutt, A.J. Dis. Colon Rectum (1981) [Pubmed]
  20. Higher testosterone dose impairs sperm suppression induced by a combined androgen-progestin regimen. Meriggiola, M.C., Costantino, A., Bremner, W.J., Morselli-Labate, A.M. J. Androl. (2002) [Pubmed]
  21. Impaired fasting glycaemia resembles impaired glucose tolerance with regard to cardiovascular risk factors: population-based, cross-sectional study of risk factors for cardiovascular disease. Heldgaard, P.E., Olivarius, N.d.e. .F., Hindsberger, C., Henriksen, J.E. Diabet. Med. (2004) [Pubmed]
  22. Diagnostic procedures in female urology. Ostergard, D.R., McCarthy, T.A. Am. J. Obstet. Gynecol. (1980) [Pubmed]
  23. Radiation pneumonitis: a possible lymphocyte-mediated hypersensitivity reaction. Roberts, C.M., Foulcher, E., Zaunders, J.J., Bryant, D.H., Freund, J., Cairns, D., Penny, R., Morgan, G.W., Breit, S.N. Ann. Intern. Med. (1993) [Pubmed]
  24. Evolution of chronic recurrent multifocal osteitis toward spondylarthropathy over the long term. Vittecoq, O., Said, L.A., Michot, C., Mejjad, O., Thomine, J.M., Mitrofanoff, P., Lechevallier, J., Ledosseur, P., Gayet, A., Lauret, P., le Loët, X. Arthritis Rheum. (2000) [Pubmed]
  25. The early diagnosis of medullary carcinoma of the thyroid gland in patients with multiple endocrine neoplasia type II. Wells, S.A., Ontjes, D.A., Cooper, C.W., Hennessy, J.F., Ellis, G.J., McPherson, H.T., Sabiston, D.C. Ann. Surg. (1975) [Pubmed]
  26. Support of evidence-based guidelines for the annual physical examination: a survey of primary care providers. Prochazka, A.V., Lundahl, K., Pearson, W., Oboler, S.K., Anderson, R.J. Arch. Intern. Med. (2005) [Pubmed]
  27. Risk factors for growth and decline of lung function in asthmatic individuals up to age 42 years. A 30-year follow-up study. Grol, M.H., Gerritsen, J., Vonk, J.M., Schouten, J.P., Koëter, G.H., Rijcken, B., Postma, D.S. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  28. Attack rate of poststreptococcal nephritis in families. A prospective study. Rodríguez-Iturbe, B., Rubio, L., García, R. Lancet (1981) [Pubmed]
  29. Food allergy. Sicherer, S.H. Lancet (2002) [Pubmed]
  30. D-Penicillamine therapy in progressive systemic sclerosis (scleroderma): a retrospective analysis. Steen, V.D., Medsger, T.A., Rodnan, G.P. Ann. Intern. Med. (1982) [Pubmed]
  31. Diagnostic accuracies of clinical studies in patients with small cell carcinoma of the lung. Chak, L.Y., Paryani, S.B., Sikic, B.I., Lockbaum, P., Torti, F.M., Carter, S.K. J. Clin. Oncol. (1983) [Pubmed]
  32. Trends in serum uric acid levels 1961--1980. Glynn, R.J., Campion, E.W., Silbert, J.E. Arthritis Rheum. (1983) [Pubmed]
  33. Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysis. Arca, M., Zuliani, G., Wilund, K., Campagna, F., Fellin, R., Bertolini, S., Calandra, S., Ricci, G., Glorioso, N., Maioli, M., Pintus, P., Carru, C., Cossu, F., Cohen, J., Hobbs, H.H. Lancet (2002) [Pubmed]
  34. Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion. Saeki, K., Zhu, M., Kubosaki, A., Xie, J., Lan, M.S., Notkins, A.L. Diabetes (2002) [Pubmed]
  35. Compound deletion of the rhoGAP C1 and V2 vasopressin receptor genes in a patient with nephrogenic diabetes insipidus. Schöneberg, T., Pasel, K., von Baehr, V., Schulz, A., Volk, H.D., Gudermann, T., Filler, G. Hum. Mutat. (1999) [Pubmed]
  36. Familial growth hormone deficiency with mutated GHRH receptor gene: clinical and hormonal findings in homozygous and heterozygous individuals from Itabaianinha. Hayashida, C.Y., Gondo, R.G., Ferrari, C., Toledo, S.P., Salvatori, R., Levine, M.A., Ezabella, M.C., Abelin, N., Gianella-Neto, D., Wajchenberg, B.L. Eur. J. Endocrinol. (2000) [Pubmed]
  37. Improved specificity of myoglobin plus carbonic anhydrase assay versus that of creatine kinase-MB for early diagnosis of acute myocardial infarction. Brogan, G.X., Vuori, J., Friedman, S., McCuskey, C.F., Thode, H.C., Vaananen, H.K., Cooling, D.S., Bock, J.L. Annals of emergency medicine. (1996) [Pubmed]
  38. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Lindor, K.D., Dickson, E.R., Baldus, W.P., Jorgensen, R.A., Ludwig, J., Murtaugh, P.A., Harrison, J.M., Wiesner, R.H., Anderson, M.L., Lange, S.M. Gastroenterology (1994) [Pubmed]
  39. Diagnosis, management, and treatment of Alzheimer disease: a guide for the internist. Richards, S.S., Hendrie, H.C. Arch. Intern. Med. (1999) [Pubmed]
  40. Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study. van Hecke, M.V., Dekker, J.M., Nijpels, G., Moll, A.C., Heine, R.J., Bouter, L.M., Polak, B.C., Stehouwer, C.D. Diabetologia (2005) [Pubmed]
  41. Cardiac manifestations of cocaine abuse: a cross-sectional study of asymptomatic men with a history of long-term abuse of "crack" cocaine. Chakko, S., Fernandez, A., Mellman, T.A., Milanes, F.J., Kessler, K.M., Myerburg, R.J. J. Am. Coll. Cardiol. (1992) [Pubmed]
  42. Peripartum cardiomyopathy: clinical, hemodynamic, histologic and prognostic characteristics. O'Connell, J.B., Costanzo-Nordin, M.R., Subramanian, R., Robinson, J.A., Wallis, D.E., Scanlon, P.J., Gunnar, R.M. J. Am. Coll. Cardiol. (1986) [Pubmed]
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