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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis.

Major histocompatibility complex (MHC)-linked deletions in the rat are associated with defects in growth and development and increased susceptibility to chemical carcinogens. The present study maps a locus critical for determining susceptibility to diethylnitrosamine (DEN) carcinogenesis by using two groups of MHC-recombinant rats congenic for the MHC and its linked region. Resistance to DEN segregates with a locus (rcc+) that maps between RT1.E and ft, and its homozygous loss markedly increases susceptibility to DEN. Non-MHC genes do not significantly influence the susceptibility of these strains to DEN. The existence of the rcc locus adds support to our hypothesis that some genes in the MHC-linked region play a major role in both normal and abnormal growth.[1]

References

  1. A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis. Melhem, M.F., Kunz, H.W., Gill, T.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
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