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Chemical Compound Review

Diethylnitrosamine     N,N-diethylnitrous amide

Synonyms: DENA, NDEA, NSC-132, CCRIS 239, DEN (mutagen), ...
 
 
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Disease relevance of Nitrosodiethylamine

 

Psychiatry related information on Nitrosodiethylamine

 

High impact information on Nitrosodiethylamine

 

Chemical compound and disease context of Nitrosodiethylamine

 

Biological context of Nitrosodiethylamine

 

Anatomical context of Nitrosodiethylamine

 

Associations of Nitrosodiethylamine with other chemical compounds

 

Gene context of Nitrosodiethylamine

 

Analytical, diagnostic and therapeutic context of Nitrosodiethylamine

References

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  3. Histologic and electron microscopy observations on diethylnitrosamine-induced hepatomas in small aquarium fish (Oryzias latipes). Ishikawa, T., Shimamine, T., Takayama, S. J. Natl. Cancer Inst. (1975) [Pubmed]
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  21. A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis. Melhem, M.F., Kunz, H.W., Gill, T.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  22. Intermediate-sized filaments in cultured rat liver tumor cells with Mallory body-like cytoplasm abnormalities. Borenfreund, E., Higgins, P.J., Peterson, E. J. Natl. Cancer Inst. (1980) [Pubmed]
  23. Autoradiography in fetal golden hamsters treated with tritiated diethylnitrosamine. Reznik-Schüller, H.M., Hague, B.F. J. Natl. Cancer Inst. (1981) [Pubmed]
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  25. Effect of phenobarbital on the development of liver tumors in juvenile and adult mice. Pereira, M.A., Klaunig, J.E., Herren-Freund, S.L., Ruch, R.J. J. Natl. Cancer Inst. (1986) [Pubmed]
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  27. Vinylethylnitrosamine: a potent respiratory carcinogen in Syrian hamsters. Althoff, J., Grandjean, C., Russell, L., Pour, P. J. Natl. Cancer Inst. (1977) [Pubmed]
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  29. Metabolic activation by hamster and rat hepatocytes in the Salmonella mutagenicity assay. Poiley, J.A., Raineri, R., Andrews, A.W., Cavanaugh, D.M., Pienta, R.J. J. Natl. Cancer Inst. (1980) [Pubmed]
  30. Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression. Bhaumik, M., Harris, T., Sundaram, S., Johnson, L., Guttenplan, J., Rogler, C., Stanley, P. Cancer Res. (1998) [Pubmed]
  31. Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis. Huang, X., Yu, C., Jin, C., Kobayashi, M., Bowles, C.A., Wang, F., McKeehan, W.L. Cancer Res. (2006) [Pubmed]
  32. Reduced hepatic tumor incidence in cyclin G1-deficient mice. Jensen, M.R., Factor, V.M., Fantozzi, A., Helin, K., Huh, C.G., Thorgeirsson, S.S. Hepatology (2003) [Pubmed]
  33. Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine. Horiguchi, N., Takayama, H., Toyoda, M., Otsuka, T., Fukusato, T., Merlino, G., Takagi, H., Mori, M. Oncogene (2002) [Pubmed]
  34. Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase. Kushida, H., Fujita, K., Suzuki, A., Yamada, M., Endo, T., Nohmi, T., Kamataki, T. Carcinogenesis (2000) [Pubmed]
  35. Induction of gamma-glutamyltransferase-positive and nonspecific esterase-positive foci in rat liver by partial hepatectomy following single injection of N-nitrosodiethylamine. Hirota, N., Moriyama, S., Yokoyama, T. J. Natl. Cancer Inst. (1982) [Pubmed]
  36. Activation of intracisternal A particles in mouse liver by diethylnitrosamine. Shinozuka, H., Estes, L.W. J. Natl. Cancer Inst. (1977) [Pubmed]
  37. Increased hepatic androgen receptor expression in female rats during diethylnitrosamine liver carcinogenesis. A possible correlation with liver tumor development. Ostrowski, J.L., Ingleton, P.M., Underwood, J.C., Parsons, M.A. Gastroenterology (1988) [Pubmed]
  38. Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis. Schiffer, E., Housset, C., Cacheux, W., Wendum, D., Desbois-Mouthon, C., Rey, C., Clergue, F., Poupon, R., Barbu, V., Rosmorduc, O. Hepatology (2005) [Pubmed]
 
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