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Chemical Compound Review

Diethylnitrosamine     N,N-diethylnitrous amide

Synonyms: DENA, NDEA, NSC-132, CCRIS 239, DEN (mutagen), ...
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Disease relevance of Nitrosodiethylamine


Psychiatry related information on Nitrosodiethylamine


High impact information on Nitrosodiethylamine


Chemical compound and disease context of Nitrosodiethylamine


Biological context of Nitrosodiethylamine


Anatomical context of Nitrosodiethylamine


Associations of Nitrosodiethylamine with other chemical compounds


Gene context of Nitrosodiethylamine


Analytical, diagnostic and therapeutic context of Nitrosodiethylamine


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  17. Lymphotoxin prevention of diethylnitrosamine carcinogenesis in vivo. Ransom, J.H., Evans, C.H., DiPaolo, J.A. J. Natl. Cancer Inst. (1982) [Pubmed]
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  21. A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis. Melhem, M.F., Kunz, H.W., Gill, T.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  22. Intermediate-sized filaments in cultured rat liver tumor cells with Mallory body-like cytoplasm abnormalities. Borenfreund, E., Higgins, P.J., Peterson, E. J. Natl. Cancer Inst. (1980) [Pubmed]
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  28. Antitumoral activity of indomethacin on experimental esophageal tumors. Rubio, C.A. J. Natl. Cancer Inst. (1984) [Pubmed]
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  30. Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression. Bhaumik, M., Harris, T., Sundaram, S., Johnson, L., Guttenplan, J., Rogler, C., Stanley, P. Cancer Res. (1998) [Pubmed]
  31. Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis. Huang, X., Yu, C., Jin, C., Kobayashi, M., Bowles, C.A., Wang, F., McKeehan, W.L. Cancer Res. (2006) [Pubmed]
  32. Reduced hepatic tumor incidence in cyclin G1-deficient mice. Jensen, M.R., Factor, V.M., Fantozzi, A., Helin, K., Huh, C.G., Thorgeirsson, S.S. Hepatology (2003) [Pubmed]
  33. Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine. Horiguchi, N., Takayama, H., Toyoda, M., Otsuka, T., Fukusato, T., Merlino, G., Takagi, H., Mori, M. Oncogene (2002) [Pubmed]
  34. Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase. Kushida, H., Fujita, K., Suzuki, A., Yamada, M., Endo, T., Nohmi, T., Kamataki, T. Carcinogenesis (2000) [Pubmed]
  35. Induction of gamma-glutamyltransferase-positive and nonspecific esterase-positive foci in rat liver by partial hepatectomy following single injection of N-nitrosodiethylamine. Hirota, N., Moriyama, S., Yokoyama, T. J. Natl. Cancer Inst. (1982) [Pubmed]
  36. Activation of intracisternal A particles in mouse liver by diethylnitrosamine. Shinozuka, H., Estes, L.W. J. Natl. Cancer Inst. (1977) [Pubmed]
  37. Increased hepatic androgen receptor expression in female rats during diethylnitrosamine liver carcinogenesis. A possible correlation with liver tumor development. Ostrowski, J.L., Ingleton, P.M., Underwood, J.C., Parsons, M.A. Gastroenterology (1988) [Pubmed]
  38. Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis. Schiffer, E., Housset, C., Cacheux, W., Wendum, D., Desbois-Mouthon, C., Rey, C., Clergue, F., Poupon, R., Barbu, V., Rosmorduc, O. Hepatology (2005) [Pubmed]
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