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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cyclin D and oncogenesis.

The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene'), and breast and squamous cell cancers. The mechanism by which deregulated production of cyclin D1/PRAD1, and perhaps other D-type cyclins, contributes to tumor development is only beginning to be deciphered.[1]


  1. Cyclin D and oncogenesis. Motokura, T., Arnold, A. Curr. Opin. Genet. Dev. (1993) [Pubmed]
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