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Montuschi, P. et al.

Interleukin-1 alpha and tumour necrosis factor inhibit rat gastric fundus motility in vitro.

In this study, the effects of tumour necrosis factor (TNF) and interleukins 1 alpha and 6 (IL-1 alpha and IL-6) on rat gastric fundus motility were investigated in vitro. IL-1 alpha and TNF induced rapid dose-dependent inhibition of stomach motility, with maximal relaxation equal to that induced by 100 microM papaverin, and respective EC50s of 20 and 450 pg/ml. IL-6 had no effect on gastric motility up to a 3 ng/ml concentration.[1]

References

Interleukin-1 alpha and tumour necrosis factor inhibit rat gastric fundus motility in vitro. Montuschi, P., Preziosi, P., Navarra, P. Eur. J. Pharmacol. (1993) [Pubmed]

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