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Gene Review

Il1a  -  interleukin 1 alpha

Rattus norvegicus

Synonyms: IL-1 alpha, Interleukin-1 alpha
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Disease relevance of Il1a


Psychiatry related information on Il1a


High impact information on Il1a


Chemical compound and disease context of Il1a


Biological context of Il1a


Anatomical context of Il1a


Associations of Il1a with chemical compounds


Regulatory relationships of Il1a


Other interactions of Il1a

  • Expression of IL-1 beta and TNF genes showed a pattern similar to that of IL-1 alpha [1].
  • The increase of IL-1 alpha and TNF-alpha mRNA in AM peaked at 1 month and 3 days after exposure to crocidolite or TW, respectively [26].
  • The aim of the present study was to examine the effect of IL-1 alpha on the amount of cyclooxygenase mRNA and protein in these cells [27].
  • These data demonstrate that IL-1 alpha increases steady-state concentrations of COX-2 mRNA and protein in endometrial stromal cells isolated from the uteri of rats that have been sensitized for decidualization [27].
  • At these IC50 doses, the ratios of IRAP/IL-1 were 12.5 and 220 for IL-1 alpha vs. -beta, respectively [30].

Analytical, diagnostic and therapeutic context of Il1a


  1. Interleukin-1 alpha, interleukin-1 beta, and tumor necrosis factor gene expression in endotoxin-induced uveitis. Yoshida, M., Yoshimura, N., Hangai, M., Tanihara, H., Honda, Y. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  2. Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell activation. Wanner, G.A., Ertel, W., Müller, P., Höfer, Y., Leiderer, R., Menger, M.D., Messmer, K. Shock (1996) [Pubmed]
  3. Early organ-specific hemorrhage-induced increases in tissue cytokine content: associated neurohormonal and opioid alterations. Molina, P.E., Malek, S., Lang, C.H., Qian, L., Naukam, R., Abumrad, N.N. Neuroimmunomodulation (1997) [Pubmed]
  4. Bradykinin decreases T-kininogen synthesis in a rat hepatoma cell line: evidence of bradykinin B2-type receptors. Raymond, P., Bouvier, M., Drapeau, G., Blais, C., Morais, R., Adam, A. Peptides (1996) [Pubmed]
  5. The role of interleukin-1 alpha in the pathogenesis of periapical bone destruction in a rat model system. Wang, C.Y., Stashenko, P. Oral Microbiol. Immunol. (1993) [Pubmed]
  6. Perinatal inflammatory cytokine challenge results in distinct neurobehavioral alterations in rats: implication in psychiatric disorders of developmental origin. Tohmi, M., Tsuda, N., Watanabe, Y., Kakita, A., Nawa, H. Neurosci. Res. (2004) [Pubmed]
  7. Central effects of tumor necrosis factor alpha and interleukin-1 alpha on nociceptive thresholds and spontaneous locomotor activity. Bianchi, M., Sacerdote, P., Ricciardi-Castagnoli, P., Mantegazza, P., Panerai, A.E. Neurosci. Lett. (1992) [Pubmed]
  8. Corticotropin releasing hormone, interleukin-1 alpha, and tumor necrosis factor-alpha share characteristics of stress mediators. Bianchi, M., Sacerdote, P., Locatelli, L., Mantegazza, P., Panerai, A.E. Brain Res. (1991) [Pubmed]
  9. Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue. Ferreira, S.H., Lorenzetti, B.B., Bristow, A.F., Poole, S. Nature (1988) [Pubmed]
  10. Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. Corbett, J.A., McDaniel, M.L. J. Exp. Med. (1995) [Pubmed]
  11. Interleukin 1 alpha causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells. Gronich, J., Konieczkowski, M., Gelb, M.H., Nemenoff, R.A., Sedor, J.R. J. Clin. Invest. (1994) [Pubmed]
  12. Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone. Centrella, M., McCarthy, T.L., Kusmik, W.F., Canalis, E. J. Clin. Invest. (1992) [Pubmed]
  13. Interleukin-1 generates transmembrane signals from phospholipids through novel pathways in cultured rat mesangial cells. Kester, M., Simonson, M.S., Mené, P., Sedor, J.R. J. Clin. Invest. (1989) [Pubmed]
  14. Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins. Fong, Y., Moldawer, L.L., Marano, M., Wei, H., Barber, A., Manogue, K., Tracey, K.J., Kuo, G., Fischman, D.A., Cerami, A. Am. J. Physiol. (1989) [Pubmed]
  15. Suppression of cytokine production by thromboxane A2 inhibitor in liver ischemia. Sugawara, Y., Harihara, Y., Takayama, T., Makuuchi, M. Hepatogastroenterology (1998) [Pubmed]
  16. The role of cell-associated interleukin-1 in bleomycin-induced pulmonary fibrosis. Asada, K., Ogushi, F., Tani, K., Maniwa, K., Ichikawa, W., Endo, T., Haung, L., Nishioka, Y., Sone, S., Ogura, T. Tokushima J. Exp. Med. (1996) [Pubmed]
  17. Possible involvement of prostaglandin E in development of ACTH response in rats induced by human recombinant interleukin-1. Morimoto, A., Murakami, N., Nakamori, T., Sakata, Y., Watanabe, T. J. Physiol. (Lond.) (1989) [Pubmed]
  18. Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression. Ulich, T.R., Guo, K.Z., Irwin, B., Remick, D.G., Davatelis, G.N. Am. J. Pathol. (1990) [Pubmed]
  19. IL-1 and IFN-gamma increase vascular permeability. Martin, S., Maruta, K., Burkart, V., Gillis, S., Kolb, H. Immunology (1988) [Pubmed]
  20. Interleukin-1 alpha inhibits the effects of gamma-interferon and tumor necrosis factor alpha on the expression of the major histocompatibility antigens by the rat endothelium. Leszczynski, D. Am. J. Pathol. (1990) [Pubmed]
  21. Evidence that interleukin-1, but not interleukin-6, affects costochondral chondrocyte proliferation, differentiation, and matrix synthesis through an autocrine pathway. Horan, J., Dean, D.D., Kieswetter, K., Schwartz, Z., Boyan, B.D. J. Bone Miner. Res. (1996) [Pubmed]
  22. Influence of interleukin 1 and antihuman interleukin 1 receptor antibody on the growth and function of the thyroid gland in rats. Zerek-Mełeń, G., Zylińska, K., Fryczak, J., Mucha, S., Stepień, H. Eur. J. Endocrinol. (1994) [Pubmed]
  23. Interleukin-1 beta but not interleukin-1 alpha, induces acute inflammation-like changes in the testicular microcirculation of adult rats. Bergh, A., Söder, O. J. Reprod. Immunol. (1990) [Pubmed]
  24. Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Schroeder, J.J., Cousins, R.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  25. Interleukin-1 induces interleukin-1 alpha and interleukin-1 beta gene expression in synovial fibroblasts and peripheral blood monocytes. Dalton, B.J., Connor, J.R., Johnson, W.J. Arthritis Rheum. (1989) [Pubmed]
  26. Effects of mineral fibers on the expression of genes whose product may play a role in fiber pathogenesis. Tsuda, T., Morimoto, Y., Yamato, H., Nakamura, H., Hori, H., Nagata, N., Kido, M., Higashi, T., Tanaka, I. Environ. Health Perspect. (1997) [Pubmed]
  27. Role of interleukin 1 in the regulation of cyclooxygenase gene expression in rat endometrial stromal cells. Bany, B.M., Kennedy, T.G. J. Reprod. Fertil. (1999) [Pubmed]
  28. Juxtacrine effects of IL-1 alpha precursor promote iNOS expression in vascular smooth muscle cells. Sasu, S., Cooper, A.L., Beasley, D. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  29. Residual bodies activate Sertoli cell interleukin-1 alpha (IL-1 alpha) release, which triggers IL-6 production by an autocrine mechanism, through the lipoxygenase pathway. Syed, V., Stéphan, J.P., Gérard, N., Legrand, A., Parvinen, M., Bardin, C.W., Jégou, B. Endocrinology (1995) [Pubmed]
  30. Interleukin-1 alpha and interleukin-1 beta stimulate adrenocorticotropin secretion in the rat through a similar hypothalamic receptor(s): effects of interleukin-1 receptor antagonist protein. Matta, S.G., Linner, K.M., Sharp, B.M. Neuroendocrinology (1993) [Pubmed]
  31. Expression of intercellular adhesion molecule-1 on rat vascular smooth muscle cells by pro-inflammatory cytokines. Ikeda, U., Ikeda, M., Seino, Y., Takahashi, M., Kasahara, T., Kano, S., Shimada, K. Atherosclerosis (1993) [Pubmed]
  32. Development and application of radioimmunoassays for interleukin-1 alpha and interleukin-1 beta. Poole, S., Bristow, A.F., Selkirk, S., Rafferty, B. J. Immunol. Methods (1989) [Pubmed]
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