Gene Review:
Il6 - interleukin 6
Rattus norvegicus
Synonyms:
IL-6, ILg6, Ifnb2, Il-6, Interleukin-6
Aasen,
Boost,
Shroff,
Cerutti,
Jarvis,
Meert,
Betz,
Goodwin,
Flondor,
Semple-Rowland,
Hartung,
Zwissler,
Vissers,
Vincken,
Stuestøl,
Sarnico,
Krohn,
De Jongh,
Bricca,
Spangelo,
Benarese,
Pfeilschifter,
Dreano,
Wang,
Homann,
Hurley,
Hofstetter,
Horrell,
Boroni,
Verniers,
Øverland,
Kurdi,
Valerio,
Garotta,
Thissen,
Pizzi,
Streit,
De Jongh,
Mathiesen,
Randon,
Spano,
McGraw,
Booij,
Muehl,
Myhre,
Dahle,
- Regulation of CCAAT/Enhancer binding protein, interleukin-6, interleukin-6 receptor, and gp130 expression during myocardial ischemia/reperfusion. Chandrasekar, B., Mitchell, D.H., Colston, J.T., Freeman, G.L. Circulation (1999)
- Involvement of PKC-beta in PTH, TNF-alpha, and IL-1 beta effects on IL-6 promoter in osteoblastic cells and on PTH-stimulated bone resorption. Radeff, J.M., Nagy, Z., Stern, P.H. Exp. Cell Res. (2001)
- Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices. Pizzi, M., Sarnico, I., Boroni, F., Benarese, M., Dreano, M., Garotta, G., Valerio, A., Spano, P. Mol. Cell. Neurosci. (2004)
- Cytokine expression by neutrophils and macrophages in vivo: endotoxin induces tumor necrosis factor-alpha, macrophage inflammatory protein-2, interleukin-1 beta, and interleukin-6 but not RANTES or transforming growth factor-beta 1 mRNA expression in acute lung inflammation. Xing, Z., Jordana, M., Kirpalani, H., Driscoll, K.E., Schall, T.J., Gauldie, J. Am. J. Respir. Cell Mol. Biol. (1994)
- Interleukin-6 and transforming growth factor-beta synergistically stimulate chondrosarcoma cell proliferation. Guerne, P.A., Lotz, M. J. Cell. Physiol. (1991)
- Induction and regulation of interleukin-6 gene expression in rat astrocytes. Benveniste, E.N., Sparacio, S.M., Norris, J.G., Grenett, H.E., Fuller, G.M. J. Neuroimmunol. (1990)
- Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Xie, Z., Morgan, T.E., Rozovsky, I., Finch, C.E. Exp. Neurol. (2003)
- Interleukin-6 alters sleep of rats. Hogan, D., Morrow, J.D., Smith, E.M., Opp, M.R. J. Neuroimmunol. (2003)
- Interleukin-6 and perioperative thermoregulation and HPA-axis activation. De Jongh, R.F., Vissers, K.C., Booij, L.H., De Jongh, K.L., Vincken, P., Meert, T.F. Cytokine (2003)
- Short-chain ceramide regulates hepatic methionine adenosyltransferase expression. Frago, L.M., Pañeda, C., Fabregat, I., Varela-Nieto, I. J. Hepatol. (2001)
- Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Trautwein, C., Caelles, C., van der Geer, P., Hunter, T., Karin, M., Chojkier, M. Nature (1993)
- Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. Villa, P., Bigini, P., Mennini, T., Agnello, D., Laragione, T., Cagnotto, A., Viviani, B., Marinovich, M., Cerami, A., Coleman, T.R., Brines, M., Ghezzi, P. J. Exp. Med. (2003)
- Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo. Portanova, J.P., Zhang, Y., Anderson, G.D., Hauser, S.D., Masferrer, J.L., Seibert, K., Gregory, S.A., Isakson, P.C. J. Exp. Med. (1996)
- Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival. Maeda, Y., Matsumoto, M., Hori, O., Kuwabara, K., Ogawa, S., Yan, S.D., Ohtsuki, T., Kinoshita, T., Kamada, T., Stern, D.M. J. Exp. Med. (1994)
- The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10. Dahle, M.K., Øverland, G., Myhre, A.E., Stuestøl, J.F., Hartung, T., Krohn, C.D., Mathiesen, Ø., Wang, J.E., Aasen, A.O. Infect. Immun. (2004)
- Somatostatin and gamma-aminobutyric acid inhibit interleukin-1 beta-stimulated release of interleukin-6 from rat C6 glioma cells. Spangelo, B.L., Horrell, S., Goodwin, A.L., Shroff, S., Jarvis, W.D. Neuroimmunomodulation (2004)
- Increased expression of IL-6 and LIF in the hypertrophied left ventricle of TGR(mRen2)27 and SHR rats. Kurdi, M., Randon, J., Cerutti, C., Bricca, G. Mol. Cell. Biochem. (2005)
- Desflurane differentially affects the release of proinflammatory cytokines in plasma and bronchoalveolar fluid of endotoxemic rats. Boost, K.A., Hofstetter, C., Flondor, M., Betz, C., Homann, M., Pfeilschifter, J., Muehl, H., Zwissler, B. Int. J. Mol. Med. (2006)
- Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Schroeder, J.J., Cousins, R.J. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation. Ulich, T.R., Yin, S., Guo, K., Yi, E.S., Remick, D., del Castillo, J. Am. J. Pathol. (1991)
- Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase. Wadt, K.A., Larsen, C.M., Andersen, H.U., Nielsen, K., Karlsen, A.E., Mandrup-Poulsen, T. Diabetes (1998)
- LIF, but not IL-6, regulates osteoprogenitor differentiation in rat calvaria cell cultures: modulation by dexamethasone. Malaval, L., Gupta, A.K., Liu, F., Delmas, P.D., Aubin, J.E. J. Bone Miner. Res. (1998)
- Mechanisms of endotoxin-induced NO, IL-6, and TNF-alpha production in activated rat hepatic stellate cells: role of p38 MAPK. Thirunavukkarasu, C., Watkins, S.C., Gandhi, C.R. Hepatology (2006)
- A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage. Shimizu, T., Szalay, L., Hsieh, Y.C., Suzuki, T., Choudhry, M.A., Bland, K.I., Chaudry, I.H. Ann. Surg. (2006)
- Activation of signal transducers and activators of transcription by alpha(1A)-adrenergic receptor stimulation in PC12 cells. Zhong, H., Murphy, T.J., Minneman, K.P. Mol. Pharmacol. (2000)
- Guanosine 3',5'-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Broderick, K.E., Zhang, T., Rangaswami, H., Zeng, Y., Zhao, X., Boss, G.R., Pilz, R.B. Mol. Endocrinol. (2007)
- Ciliary neurotrophic factor regulates fibrinogen gene expression in hepatocytes by binding to the interleukin-6 receptor. Nesbitt, J.E., Fuentes, N.L., Fuller, G.M. Biochem. Biophys. Res. Commun. (1993)
- Isolation of two interleukin-6 response element binding proteins from acute phase rat livers. Ripperger, J., Fritz, S., Richter, K., Dreier, B., Schneider, K., Löchner, K., Marschalek, R., Hocke, G., Lottspeich, F., Fey, G.H. Ann. N. Y. Acad. Sci. (1995)
- Inhibition by interleukin-1 beta and tumor necrosis factor-alpha of the insulin-like growth factor I messenger ribonucleic acid response to growth hormone in rat hepatocyte primary culture. Thissen, J.P., Verniers, J. Endocrinology (1997)
- Interleukin-1 beta enhances survival and interleukin-6 protects against MPP+ neurotoxicity in cultures of fetal rat dopaminergic neurons. Akaneya, Y., Takahashi, M., Hatanaka, H. Exp. Neurol. (1995)
- Interleukin-6 increases rat metalloproteinase-13 gene expression through Janus kinase-2-mediated inhibition of serine/threonine phosphatase-2A. de la Torre, P., Díaz-Sanjuán, T., García-Ruiz, I., Esteban, E., Canga, F., Muñoz-Yagüe, T., Solís-Herruzo, J.A. Cell. Signal. (2005)
- IL-6 up-regulates CNTF mRNA expression and enhances neurite regeneration. Shuto, T., Horie, H., Hikawa, N., Sango, K., Tokashiki, A., Murata, H., Yamamoto, I., Ishikawa, Y. Neuroreport (2001)
- Cytokine mRNA expression in postischemic/reperfused myocardium. Herskowitz, A., Choi, S., Ansari, A.A., Wesselingh, S. Am. J. Pathol. (1995)
- The expression of interleukin-6 (IL-6), IL-6 receptor, and gp130-kilodalton glycoprotein in the rat decidua and a decidual cell line: regulation by 17beta-estradiol and prolactin. Deb, S., Tessier, C., Prigent-Tessier, A., Barkai, U., Ferguson-Gottschall, S., Srivastava, R.K., Faliszek, J., Gibori, G. Endocrinology (1999)
- Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration. Streit, W.J., Hurley, S.D., McGraw, T.S., Semple-Rowland, S.L. J. Neurosci. Res. (2000)