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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Early and selective induction of apoptosis in human leukemic cells by the alkyl-lysophospholipid ET-18-OCH3.

We have found that the alkyl-lysophospholipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) was able to induce apoptosis in human promyelocytic HL-60 leukemic cells, as evidenced by the internucleosomal degradation of the cellular DNA into the characteristic 180-200 bp DNA fragments. This effect was observed after short periods of cell incubation (6 h) with low doses of ET-18-OCH3 (3 micrograms/ml). Furthermore, we found that ET-18-OCH3 also induced rapidly apoptosis in human promonocytic U937 leukemic cells. In contrast, 3T3 fibroblasts were resistant to the alkyl-lysophospholipid. ET-18-OCH3 induced apoptotic cell death of tumor epithelial-like HELA cells, but this process required prolonged times of incubation. These data demonstrate that ET-18-OCH3 promotes a rapid and selective programmed cell death in human leukemic cells, providing an explanation to the previously described cytotoxic effects of this compound on leukemic cells.[1]

References

  1. Early and selective induction of apoptosis in human leukemic cells by the alkyl-lysophospholipid ET-18-OCH3. Mollinedo, F., Martínez-Dalmau, R., Modolell, M. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
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