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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Targeted expression of the ret/ PTC1 oncogene induces papillary thyroid carcinomas.

The ret/ PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/ PTC1 oncogene developed thyroid carcinomas with considerable similarities to human papillary thyroid carcinomas, particularly in the nuclear cytologic features and the presence of local invasion. Our findings indicate that ret/ PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papillary thyroid carcinoma.[1]

References

  1. Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Jhiang, S.M., Sagartz, J.E., Tong, Q., Parker-Thornburg, J., Capen, C.C., Cho, J.Y., Xing, S., Ledent, C. Endocrinology (1996) [Pubmed]
 
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