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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice.

A slight increase in mean corpuscular hemoglobin (MCH) has been reported in erythrocytes from human fragile X patients. As it is difficult to perform case-controlled studies in patients with fragile X syndrome, we studied MCH in erythrocytes from transgenic mice with an Fmr1 knockout. None of the knockout mice showed increased MCH levels when compared with normal littermates. We conclude that it is unlikely that the FMR1 gene product has an effect on MCH.[1]


  1. Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice. Reyniers, E., Van Bockstaele, D.R., De Boulle, K., Kooy, R.F., Bakker, C.E., Oostra, B.A., Willems, P.J. Hum. Genet. (1996) [Pubmed]
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