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MeSH Review

Erythrocyte Indices

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Disease relevance of Erythrocyte Indices


Psychiatry related information on Erythrocyte Indices


High impact information on Erythrocyte Indices


Chemical compound and disease context of Erythrocyte Indices


Biological context of Erythrocyte Indices


Anatomical context of Erythrocyte Indices


Associations of Erythrocyte Indices with chemical compounds

  • An increase in the mean corpuscular volume (MCV), while not diagnostic of vitamin B12 or folate deficiency, is a valuable, readily available screening test [10].
  • The serum gamma-glutamyl-transpeptidase (gamma-G.T.), aspartate transaminase (A.T.), urate, and triglyceride levels and the mean cell volume were estimated in 2034 healthy men [28].
  • After one month of desferrioxamine, serum aluminium (including the chelate) had risen from 54.6 (SEM 11.2) to 167.0 (27.5) micrograms/l; and after three months haemoglobin had risen from 8.46 (0.70) to 10.43 (0.80) g/l. Mean cell volume and mean cell haemoglobin concentration also increased significantly [29].
  • Mean corpuscular volume increased markedly in patients on zidovudine therapy not developing anemia yet remained stable or only slightly increased in those who became anemic [30].
  • The exact contribution of the interrelated factors in cystamine inhibition of sickling (changes in oxygen affinity, mean corpuscular hemoglobin concentration, and minimum gelling concentration) has yet to be determined [31].

Gene context of Erythrocyte Indices

  • In participants with HFE mutations, the average serum transferrin saturation and ferritin levels were slightly increased, as were mean hemoglobin levels and mean corpuscular volume [32].
  • The mean cell volume of the TM delta gts1 cells in the unbudded period (single cells) was 27% smaller than that of single wild-type cells, whereas that of single TMpGTS1 cells was 48% larger [33].
  • Moreover, intracellular expression of Hst 5 resulted in a reduction in the population mean cell volume that was accompanied by an increase in the percentage of unbudded cells and C. albicans cells in the G(1) phase [34].
  • Mice homozygous for the mk mutation have a severe hypochromic, microcytic anemia that is characterized by a decreased mean-corpuscular hemoglobin concentration and balanced alpha- and beta-globin-chain synthesis [35].
  • PP14 concentration was negatively correlated with maternal haemoglobin concentration (P = 0.010), mean corpuscular volume (P = 0.003) and serum ferritin concentration (P = 0.016) [36].

Analytical, diagnostic and therapeutic context of Erythrocyte Indices


  1. Vitamin B12 deficiency and early rise in mean corpuscular volume. Smith, T.J., Malon, R.G. JAMA (1982) [Pubmed]
  2. Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexate therapy. Weinblatt, M.E., Fraser, P. Arthritis Rheum. (1989) [Pubmed]
  3. Red cell distribution width, mean corpuscular volume, and transferrin saturation in the diagnosis of iron deficiency. Thompson, W.G., Meola, T., Lipkin, M., Freedman, M.L. Arch. Intern. Med. (1988) [Pubmed]
  4. Human immunodeficiency virus 1 infection, cocaine, and coronary calcification. Lai, S., Lima, J.A., Lai, H., Vlahov, D., Celentano, D., Tong, W., Bartlett, J.G., Margolick, J., Fishman, E.K. Arch. Intern. Med. (2005) [Pubmed]
  5. Diagnosis of iron deficiency anemia in a rural population of children. Relative usefulness of serum ferritin, red cell protoporphyrin, red cell indices, and transferrin saturation determinations. Hershko, C., Bar-Or, D., Gaziel, Y., Naparstek, E., Konijn, A.M., Grossowicz, N., Kaufman, N., Izak, G. Am. J. Clin. Nutr. (1981) [Pubmed]
  6. Screening for excessive alcohol drinking. Comparative value of carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume. Yersin, B., Nicolet, J.F., Dercrey, H., Burnier, M., van Melle, G., Pécoud, A. Arch. Intern. Med. (1995) [Pubmed]
  7. Use of biomarkers for alcohol use disorders in clinical practice. Neumann, T., Spies, C. Addiction (2003) [Pubmed]
  8. Sickle cell disease as a cause of osteonecrosis of the femoral head. Milner, P.F., Kraus, A.P., Sebes, J.I., Sleeper, L.A., Dukes, K.A., Embury, S.H., Bellevue, R., Koshy, M., Moohr, J.W., Smith, J. N. Engl. J. Med. (1991) [Pubmed]
  9. Biochemical diagnosis of alcoholism. A test of the discriminating capabilities of gamma-glutamyl transpeptidase and mean corpuscular volume. Eckardt, M.J., Ryback, R.S., Rawlings, R.R., Graubard, B.I. JAMA (1981) [Pubmed]
  10. Vitamin B12 deficiency and early rise in mean corpuscular volume. Hall, C.A. JAMA (1981) [Pubmed]
  11. Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease. De Franceschi, L., Saadane, N., Trudel, M., Alper, S.L., Brugnara, C., Beuzard, Y. J. Clin. Invest. (1994) [Pubmed]
  12. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. Stabler, S.P., Marcell, P.D., Podell, E.R., Allen, R.H., Savage, D.G., Lindenbaum, J. J. Clin. Invest. (1988) [Pubmed]
  13. Severe hepatotoxicity associated with nevirapine use in HIV-infected subjects. Sanne, I., Mommeja-Marin, H., Hinkle, J., Bartlett, J.A., Lederman, M.M., Maartens, G., Wakeford, C., Shaw, A., Quinn, J., Gish, R.G., Rousseau, F. J. Infect. Dis. (2005) [Pubmed]
  14. Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men. Yokoyama, A., Yokoyama, T., Muramatsu, T., Omori, T., Matsushita, S., Higuchi, S., Maruyama, K., Ishii, H. Carcinogenesis (2003) [Pubmed]
  15. Different resistance of mammalian red blood cells to hemolysis by bile salts. Salvioli, G., Gaetti, E., Panini, R., Lugli, R., Pradelli, J.M. Lipids (1993) [Pubmed]
  16. The individual and combined toxicity of kojic acid and aflatoxin in broiler chickens. Giroir, L.E., Huff, W.E., Kubena, L.F., Harvey, R.B., Elissalde, M.H., Witzel, D.A., Yersin, A.G., Ivie, G.W. Poult. Sci. (1991) [Pubmed]
  17. A multivariate assessment of alcohol consumption. Whitfield, J.B., Allen, J.K., Adena, M., Gallagher, H.G., Hensley, W.J. International journal of epidemiology. (1981) [Pubmed]
  18. Mice with a targeted disruption of the Fanconi anemia homolog Fanca. Cheng, N.C., van de Vrugt, H.J., van der Valk, M.A., Oostra, A.B., Krimpenfort, P., de Vries, Y., Joenje, H., Berns, A., Arwert, F. Hum. Mol. Genet. (2000) [Pubmed]
  19. Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis. Cazzola, M., Ponchio, L., de Benedetti, F., Ravelli, A., Rosti, V., Beguin, Y., Invernizzi, R., Barosi, G., Martini, A. Blood (1996) [Pubmed]
  20. Absent phenotypic expression of X-linked sideroblastic anemia in one of 2 brothers with a novel ALAS2 mutation. Cazzola, M., May, A., Bergamaschi, G., Cerani, P., Ferrillo, S., Bishop, D.F. Blood (2002) [Pubmed]
  21. Toxicological effects of chlorite in the mouse. Moore, G.S., Calabrese, E.J. Environ. Health Perspect. (1982) [Pubmed]
  22. Differential reduction by caffeine of adriamycin induced cell killing and cell cycle delays in Chinese hamster V79 cells. Iliakis, G., Nusse, M., Ganapathi, R., Egner, J., Yen, A. Int. J. Radiat. Oncol. Biol. Phys. (1986) [Pubmed]
  23. The diagnosis of iron deficiency anemia in sickle cell disease. Vichinsky, E., Kleman, K., Embury, S., Lubin, B. Blood (1981) [Pubmed]
  24. Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study. Hankins, J.S., Ware, R.E., Rogers, Z.R., Wynn, L.W., Lane, P.A., Scott, J.P., Wang, W.C. Blood (2005) [Pubmed]
  25. Cachectin/tumor necrosis factor-alpha alters red blood cell kinetics and induces anemia in vivo. Moldawer, L.L., Marano, M.A., Wei, H., Fong, Y., Silen, M.L., Kuo, G., Manogue, K.R., Vlassara, H., Cohen, H., Cerami, A. FASEB J. (1989) [Pubmed]
  26. Insulin binding and hexose transport in rat adipocytes. Relation to cell size. Foley, J.E., Laursen, A.L., Sonne, O., Gliemann, J. Diabetologia (1980) [Pubmed]
  27. NAD metabolism and mitogen stimulation of human lymphocytes. Williams, G.T., Lau, K.M., Coote, J.M., Johnstone, A.P. Exp. Cell Res. (1985) [Pubmed]
  28. Biochemical and haematological markers of alcohol intake. Whitehead, T.P., Clarke, C.A., Whitfield, A.G. Lancet (1978) [Pubmed]
  29. Aluminium chelation therapy in dialysis patients: evidence for inhibition of haemoglobin synthesis by low levels of aluminium. Altmann, P., Plowman, D., Marsh, F., Cunningham, J. Lancet (1988) [Pubmed]
  30. Anemia and erythropoiesis in patients with the acquired immunodeficiency syndrome (AIDS) and Kaposi sarcoma treated with zidovudine. Walker, R.E., Parker, R.I., Kovacs, J.A., Masur, H., Lane, H.C., Carleton, S., Kirk, L.E., Gralnick, H.R., Fauci, A.S. Ann. Intern. Med. (1988) [Pubmed]
  31. Inhibition of erythrocyte sickling by cystamine, a thiol reagent. Hassan, W., Beuzard, Y., Rosa, J. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  32. The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic. Beutler, E., Felitti, V., Gelbart, T., Ho, N. Ann. Intern. Med. (2000) [Pubmed]
  33. The GTS1 gene, which contains a Gly-Thr repeat, affects the timing of budding and cell size of the yeast Saccharomyces cerevisiae. Mitsui, K., Yaguchi, S., Tsurugi, K. Mol. Cell. Biol. (1994) [Pubmed]
  34. Human salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicans. Baev, D., Li, X.S., Dong, J., Keng, P., Edgerton, M. Infect. Immun. (2002) [Pubmed]
  35. Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. Ney, P.A., Farina, S.F., Bodine, D.M., Andrews, N.C., Orkin, S.H., Neinhuis, A.W. Exp. Hematol. (1995) [Pubmed]
  36. Relationships between the uterine environment and maternal plasma concentrations of insulin-like growth factor binding protein-1 and placental protein 14 in early pregnancy. Wheeler, T., Chard, T., Anthony, F., Osmond, C. Hum. Reprod. (1995) [Pubmed]
  37. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Skikne, B.S., Flowers, C.H., Cook, J.D. Blood (1990) [Pubmed]
  38. Wine, beer, and mortality in middle-aged men from eastern France. Renaud, S.C., Guéguen, R., Siest, G., Salamon, R. Arch. Intern. Med. (1999) [Pubmed]
  39. The effect of supplemental ascorbic acid on serum vitamin B12 levels in myelomeningocele patients. Ekvall, S., Chen, I.W., Bozian, R. Am. J. Clin. Nutr. (1981) [Pubmed]
  40. Regulation of thyroid cell volumes and fluid transport: opposite effects of TSH and iodide on cultured cells. Cauvi, D., Penel, C., Nlend, M.C., Venot, N., Allasia, C., Chabaud, O. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  41. Serum ferritin as indicator of iron responsive anaemia in patients with rheumatoid arthritis. Hansen, T.M., Hansen, N.E. Ann. Rheum. Dis. (1986) [Pubmed]
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