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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives.

New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.[1]

References

  1. Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives. Sakai, T., Kawai, H., Kamishohara, M., Odagawa, A., Suzuki, A., Uchida, T., Kawasaki, T., Tsuruo, T., Otake, N. J. Antibiot. (1995) [Pubmed]
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