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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma.

We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extraneurologic signs and autoantibodies. We suggest that this is a case of cerebral vasculitis with an autoimmune mechanism triggered by interleukin-2 therapy.[1]


  1. Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma. Michel, M., Vincent, F., Sigal, R., Damaj, G., Bensousan, T.A., Leclercq, B., Escudier, B. Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy. (1995) [Pubmed]
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