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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.

The genetic background of T lymphocytes influences development of the T helper ( TH) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2 mice. Although naive T cells from both strains initially responded to IL-12, BALB/c T cells lost IL-12 responsiveness after stimulation with antigen in vitro, even when cocultured with B10.D2 T cells. Thus, susceptibility of BALB/c mice to infection with L. major may derive from the loss of the ability to generate IL-12-induced TH1 responses rather than from an IL-4-induced TH2 response.[1]


  1. Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development. Güler, M.L., Gorham, J.D., Hsieh, C.S., Mackey, A.J., Steen, R.G., Dietrich, W.F., Murphy, K.M. Science (1996) [Pubmed]
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