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Gene Review

Il4i1  -  interleukin 4 induced 1

Mus musculus

Synonyms: Fig1, Fig1-ps, LAAO, LAO
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Disease relevance of Il4i1


High impact information on Il4i1


Biological context of Il4i1


Anatomical context of Il4i1


Associations of Il4i1 with chemical compounds


Physical interactions of Il4i1


Regulatory relationships of Il4i1


Other interactions of Il4i1

  • One unknown gene (designated Fig1 for IL-Four Induced Gene 1) and one gene with homology to the human transcription factor E4BP4 were confirmed by Northern blot analysis to be induced 10-20-fold by IL-4 treatment [24].
  • In this report, we show that the impaired IL-4-induced proliferative response of Stat6-deficient lymphocytes is not due to an inability to activate alternate signaling pathways, such as those involving insulin receptor substrates, or to a failure to upregulate IL-4 receptor levels [25].
  • Although it is well established that interleukin 4 (IL-4) is a potent anti-apoptotic cytokine for B lymphocytes, little is known about the IL-4-induced molecular events regulating cell survival [26].
  • Interferon-gamma is produced by activated immature mouse thymocytes and inhibits the interleukin 4-induced proliferation of immature thymocytes [27].
  • The IL-4-induced generation of peripheral Tregs was independent of the presence of TGF-beta or IL-10, but was dependent on Ag-specific stimulation and B7 costimulation [28].

Analytical, diagnostic and therapeutic context of Il4i1

  • The fact that ICOS ligation of wild-type T cells significantly enhanced IL-4-induced Stat6 phosphorylation and primary GATA-3 induction, but not IL-4 transcription, of naive CD4+ T cells was consistent with the results obtained from ICOS-/- T cell experiments [29].
  • Similar to IL-2, IL-4 induced blastogenesis and the generation of large granular lymphocytes, all LAK activity observed was exclusively associated with the large granular lymphocyte fraction, and the cytolytic effector cells were heterogeneous in regards to cell surface phenotype [30].
  • The latter also inhibited IL-4 induced over-expression of MCP-1 mRNA measured by classical and real time RT-PCR [31].
  • PCR analysis of gamma 1 germline transcript expression in clonal B cell cultures or single pre-activated B cells, shows that the IL-4 induced increase in the frequency of cells expressing gamma 1 germline transcripts directly correlates with the increased frequency of cells switching from IgM to IgG1 production [32].
  • A cell surface ELISA to detect interleukin-4-induced class II MHC expression on murine B cells [33].


  1. IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization. Mason, J.M., Naidu, M.D., Barcia, M., Porti, D., Chavan, S.S., Chu, C.C. J. Immunol. (2004) [Pubmed]
  2. IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice. Biedermann, T., Zimmermann, S., Himmelrich, H., Gumy, A., Egeter, O., Sakrauski, A.K., Seegmüller, I., Voigt, H., Launois, P., Levine, A.D., Wagner, H., Heeg, K., Louis, J.A., Röcken, M. Nat. Immunol. (2001) [Pubmed]
  3. Participation of endogenously produced interferon gamma in interleukin 4-mediated tumor rejection. Nishihori, H., Tsuji, H., Wang, H., Tahara, H., Akiyama, M., Ogawa, Y., Matsushima, K., Iwakura, Y., Mukaida, N. Hum. Gene Ther. (2000) [Pubmed]
  4. Systemic treatment with interleukin-4 induces regression of pulmonary metastases in a murine renal cell carcinoma model. Hillman, G.G., Younes, E., Visscher, D., Ali, E., Lam, J.S., Montecillo, E., Pontes, J.E., Haas, G.P., Puri, R.K. Cell. Immunol. (1995) [Pubmed]
  5. L-amino acid oxidase activity of an antineoplastic factor of a marine mollusk and its relationship to cytotoxicity. Iijima, R., Kisugi, J., Yamazaki, M. Dev. Comp. Immunol. (2003) [Pubmed]
  6. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Shimoda, K., van Deursen, J., Sangster, M.Y., Sarawar, S.R., Carson, R.T., Tripp, R.A., Chu, C., Quelle, F.W., Nosaka, T., Vignali, D.A., Doherty, P.C., Grosveld, G., Paul, W.E., Ihle, J.N. Nature (1996) [Pubmed]
  7. Second class minors: molecular identification of the autosomal H46 histocompatibility locus as a peptide presented by major histocompatibility complex class II molecules. Sahara, H., Shastri, N. J. Exp. Med. (2003) [Pubmed]
  8. The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages. Iniesta, V., Gómez-Nieto, L.C., Corraliza, I. J. Exp. Med. (2001) [Pubmed]
  9. Transient inhibition of interleukin 4 signaling by T cell receptor ligation. Zhu, J., Huang, H., Guo, L., Stonehouse, T., Watson, C.J., Hu-Li, J., Paul, W.E. J. Exp. Med. (2000) [Pubmed]
  10. IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaB. Abu-Amer, Y. J. Clin. Invest. (2001) [Pubmed]
  11. Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells. Suto, A., Nakajima, H., Hirose, K., Suzuki, K., Kagami, S., Seto, Y., Hoshimoto, A., Saito, Y., Foster, D.C., Iwamoto, I. Blood (2002) [Pubmed]
  12. Bacterial CpG-DNA triggers activation and maturation of human CD11c-, CD123+ dendritic cells. Bauer, M., Redecke, V., Ellwart, J.W., Scherer, B., Kremer, J.P., Wagner, H., Lipford, G.B. J. Immunol. (2001) [Pubmed]
  13. Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts. McGaha, T.L., Le, M., Kodera, T., Stoica, C., Zhu, J., Paul, W.E., Bona, C.A. Arthritis Rheum. (2003) [Pubmed]
  14. IL-4 induces loss of B lymphocyte Fc gamma R II ligand binding capacity. Laszlo, G., Dickler, H.B. J. Immunol. (1988) [Pubmed]
  15. Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis. Chu, C.C., Paul, W.E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  16. Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. Rothenberg, M.E., Luster, A.D., Leder, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  17. IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells. Ahmad, F., Gao, G., Wang, L.M., Landstrom, T.R., Degerman, E., Pierce, J.H., Manganiello, V.C. J. Immunol. (1999) [Pubmed]
  18. Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the alpha 4 integrin. Hickey, M.J., Granger, D.N., Kubes, P. J. Immunol. (1999) [Pubmed]
  19. IL-4 modulates transcriptional control of the mannose receptor in mouse FSDC dendritic cells. Egan, B.S., Abdolrasulnia, R., Shepherd, V.L. Arch. Biochem. Biophys. (2004) [Pubmed]
  20. A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction. Grunewald, S.M., Kunzmann, S., Schnarr, B., Ezernieks, J., Sebald, W., Duschl, A. J. Biol. Chem. (1997) [Pubmed]
  21. IL-4-induced STAT6 suppresses IFN-gamma-stimulated STAT1-dependent transcription in mouse macrophages. Ohmori, Y., Hamilton, T.A. J. Immunol. (1997) [Pubmed]
  22. Establishment of different T cell sublines using either interleukin 2 or interleukin 4 as growth factors. Schmitt, E., Van Brandwijk, R., Fischer, H.G., Rüde, E. Eur. J. Immunol. (1990) [Pubmed]
  23. Granulocyte-macrophage colony-stimulating factor is a major macrophage fusion factor present in conditioned medium of concanavalin A-stimulated spleen cell cultures. Abe, E., Ishimi, Y., Jin, C.H., Hong, M.H., Sato, T., Suda, T. J. Immunol. (1991) [Pubmed]
  24. Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Chu, C.C., Paul, W.E. Mol. Immunol. (1998) [Pubmed]
  25. Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression. Kaplan, M.H., Daniel, C., Schindler, U., Grusby, M.J. Mol. Cell. Biol. (1998) [Pubmed]
  26. Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. Wurster, A.L., Rodgers, V.L., White, M.F., Rothstein, T.L., Grusby, M.J. J. Biol. Chem. (2002) [Pubmed]
  27. Interferon-gamma is produced by activated immature mouse thymocytes and inhibits the interleukin 4-induced proliferation of immature thymocytes. Ransom, J., Fischer, M., Mosmann, T., Yokota, T., DeLuca, D., Schumacher, J., Zlotnik, A. J. Immunol. (1987) [Pubmed]
  28. The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors. Skapenko, A., Kalden, J.R., Lipsky, P.E., Schulze-Koops, H. J. Immunol. (2005) [Pubmed]
  29. ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling. Watanabe, M., Watanabe, S., Hara, Y., Harada, Y., Kubo, M., Tanabe, K., Toma, H., Abe, R. J. Immunol. (2005) [Pubmed]
  30. IL-4-induced lymphokine-activated killer cells. Lytic activity is mediated by phenotypically distinct natural killer-like and T cell-like large granular lymphocytes. Peace, D.J., Kern, D.E., Schultz, K.R., Greenberg, P.D., Cheever, M.A. J. Immunol. (1988) [Pubmed]
  31. Pro-atherogenic effect of interleukin-4 in endothelial cells: Modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression. Walch, L., Massade, L., Dufilho, M., Brunet, A., Rendu, F. Atherosclerosis (2006) [Pubmed]
  32. The IL-4 induced increase in the frequency of resting murine splenic B cells expressing germline Ig heavy chain gamma 1 transcripts correlates with subsequent switching to IgG1. Goodman, D.J., Gaff, C., Gerondakis, S. Int. Immunol. (1993) [Pubmed]
  33. A cell surface ELISA to detect interleukin-4-induced class II MHC expression on murine B cells. Bartlett, W.C., Noelle, R.J. J. Immunol. Methods (1987) [Pubmed]
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