- A duplication/paracentric inversion associated with familial X-linked deafness (DFN3) suggests the presence of a regulatory element more than 400 kb upstream of the POU3F4 gene. de Kok, Y.J., Merkx, G.F., van der Maarel, S.M., Huber, I., Malcolm, S., Ropers, H.H., Cremers, F.P. Hum. Mol. Genet. (1995)