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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

HPCX  -  hereditary prostate cancer, X-linked

Homo sapiens

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Disease relevance of HPCX


Psychiatry related information on HPCX


High impact information on HPCX


Chemical compound and disease context of HPCX


Biological context of HPCX


Anatomical context of HPCX

  • OBJECTIVES: In this study we used arsenic-transformed human prostate epithelial cells, which also show androgen-independent growth, to study the possibility that chronic activation of Ras/MAPK signaling may contribute to arsenic-induced prostate cancer progression [23].
  • METHODS.: The in vitro proapoptotic effects of honokiol on human androgen-dependent and -independent PCa, bone marrow, bone marrow-derived endothelial, and prostate stroma cells were investigated [2].
  • Therefore, we have now investigated the response of DU-145 cells, a well characterized androgen-independent human prostate cancer (PCA) cell line, to this phenylpropanoid derivative [24].
  • Prostate cancer disseminates initially and primarily to regional lymph nodes [4].
  • BACKGROUND: Prostate cancer promotes the development of T cell tolerance towards prostatic antigens, potentially limiting the efficacy of prostate cancer vaccines targeting these antigens [25].

Associations of HPCX with chemical compounds

  • Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells [2].
  • We now report that treatment of DU-145 and LNCaP prostate cancer cell lines with histone deacetylase inhibitor trichostatin A (TSA) or CGK1026 resulted in transcriptional activation of the IFI16 gene [26].
  • It has been proposed that AR mutations such as Thr877-->Ala, Trp741-->Leu, and Trp741-->Cys that cause anti-androgens such as flutamide and bicalutamide to function as agonists are likely associated with anti-androgen withdrawal syndrome in PCa therapy [27].
  • Ten-year survival and cardiovascular mortality in patients with advanced prostate cancer primarily treated by intramuscular polyestradiol phosphate or orchiectomy [28].
  • Prostate cancer cells, like normal prostate epithelial cells, produce high levels of the differentiation marker and serine protease prostate-specific antigen (PSA) [29].

Physical interactions of HPCX

  • X-linked CGD patients have mutations in the gene encoding the gp91(phox) subunit of cytochrome b558 and usually lack gp91(phox) protein completely (X91(0)). gp91(phox) is considered to be a flavocytochrome that contains binding sites for NADPH, FAD, as well as heme [30].

Regulatory relationships of HPCX


Other interactions of HPCX


Analytical, diagnostic and therapeutic context of HPCX


  1. Linkage analysis of 153 prostate cancer families over a 30-cM region containing the putative susceptibility locus HPCX. Lange, E.M., Chen, H., Brierley, K., Perrone, E.E., Bock, C.H., Gillanders, E., Ray, M.E., Cooney, K.A. Clin. Cancer Res. (1999) [Pubmed]
  2. Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Shigemura, K., Arbiser, J.L., Sun, S.Y., Zayzafoon, M., Johnstone, P.A., Fujisawa, M., Gotoh, A., Weksler, B., Zhau, H.E., Chung, L.W. Cancer (2007) [Pubmed]
  3. Physical and transcript map of the hereditary prostate cancer region at xq27. Stephan, D.A., Howell, G.R., Teslovich, T.M., Coffey, A.J., Smith, L., Bailey-Wilson, J.E., Malechek, L., Gildea, D., Smith, J.R., Gillanders, E.M., Schleutker, J., Hu, P., Steingruber, H.E., Dhami, P., Robbins, C.M., Makalowska, I., Carpten, J.D., Sood, R., Mumm, S., Reinbold, R., Bonner, T.I., Baffoe-Bonnie, A., Bubendorf, L., Heiskanen, M., Kallioneimi, O.P., Baxevanis, A.D., Joseph, S.S., Zucchi, I., Burk, R.D., Isaacs, W., Ross, M.T., Trent, J.M. Genomics (2002) [Pubmed]
  4. Tumor-Induced Activation of Lymphatic Endothelial Cells via Vascular Endothelial Growth Factor Receptor-2 Is Critical for Prostate Cancer Lymphatic Metastasis. Zeng, Y., Opeskin, K., Goad, J., Williams, E.D. Cancer Res. (2006) [Pubmed]
  5. Race/ethnicity, obesity, health related behaviors and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. Kristal, A.R., Arnold, K.B., Schenk, J.M., Neuhouser, M.L., Weiss, N., Goodman, P., Antvelink, C.M., Penson, D.F., Thompson, I.M. J. Urol. (2007) [Pubmed]
  6. Psychological adjustment of men with prostate cancer: a review of the literature. Bloch, S., Love, A., Macvean, M., Duchesne, G., Couper, J., Kissane, D. BioPsychoSocial medicine (2007) [Pubmed]
  7. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. Zemni, R., Bienvenu, T., Vinet, M.C., Sefiani, A., Carrié, A., Billuart, P., McDonell, N., Couvert, P., Francis, F., Chafey, P., Fauchereau, F., Friocourt, G., des Portes, V., Cardona, A., Frints, S., Meindl, A., Brandau, O., Ronce, N., Moraine, C., van Bokhoven, H., Ropers, H.H., Sudbrak, R., Kahn, A., Fryns, J.P., Beldjord, C., Chelly, J. Nat. Genet. (2000) [Pubmed]
  8. X-linked recessive inheritance of ataxia and adult-onset dementia: clinical features and preliminary linkage analysis. Farlow, M.R., DeMyer, W., Dlouhy, S.R., Hodes, M.E. Neurology (1987) [Pubmed]
  9. Soy product and isoflavone consumption in relation to prostate cancer in Japanese men. Kurahashi, N., Iwasaki, M., Sasazuki, S., Otani, T., Inoue, M., Tsugane, S. Cancer Epidemiol. Biomarkers Prev. (2007) [Pubmed]
  10. Cortical tissue of patients with hereditary cerebral hemorrhage with amyloidosis (Dutch) contains various extracellular matrix deposits. van Duinen, S.G., Maat-Schieman, M.L., Bruijn, J.A., Haan, J., Roos, R.A. Lab. Invest. (1995) [Pubmed]
  11. The benefit and cost of prostate cancer early detection. The Investigators of the American Cancer Society-National Prostate Cancer Detection Project. Littrup, P.J., Goodman, A.C., Mettlin, C.J. CA: a cancer journal for clinicians. (1993) [Pubmed]
  12. The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases. Iwase, S., Lan, F., Bayliss, P., de la Torre-Ubieta, L., Huarte, M., Qi, H.H., Whetstine, J.R., Bonni, A., Roberts, T.M., Shi, Y. Cell (2007) [Pubmed]
  13. X-linked Cornelia de Lange syndrome owing to SMC1L1 mutations. Musio, A., Selicorni, A., Focarelli, M.L., Gervasini, C., Milani, D., Russo, S., Vezzoni, P., Larizza, L. Nat. Genet. (2006) [Pubmed]
  14. X-linked inheritance of Fanconi anemia complementation group B. Meetei, A.R., Levitus, M., Xue, Y., Medhurst, A.L., Zwaan, M., Ling, C., Rooimans, M.A., Bier, P., Hoatlin, M., Pals, G., de Winter, J.P., Wang, W., Joenje, H. Nat. Genet. (2004) [Pubmed]
  15. FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. Meloni, I., Muscettola, M., Raynaud, M., Longo, I., Bruttini, M., Moizard, M.P., Gomot, M., Chelly, J., des Portes, V., Fryns, J.P., Ropers, H.H., Magi, B., Bellan, C., Volpi, N., Yntema, H.G., Lewis, S.E., Schaffer, J.E., Renieri, A. Nat. Genet. (2002) [Pubmed]
  16. Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate. Waytes, A.T., Rosen, F.S., Frank, M.M. N. Engl. J. Med. (1996) [Pubmed]
  17. X-linked pyridoxine-responsive sideroblastic anemia due to a Thr388-to-Ser substitution in erythroid 5-aminolevulinate synthase. Cox, T.C., Bottomley, S.S., Wiley, J.S., Bawden, M.J., Matthews, C.S., May, B.K. N. Engl. J. Med. (1994) [Pubmed]
  18. X-linked, pyridoxine-responsive sideroblastic anemia. Harris, J.W. N. Engl. J. Med. (1994) [Pubmed]
  19. Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus. Pan, Y., Metzenberg, A., Das, S., Jing, B., Gitschier, J. Nat. Genet. (1992) [Pubmed]
  20. A genetic epidemiological study of hereditary prostate cancer (HPC) in Finland: frequent HPCX linkage in families with late-onset disease. Schleutker, J., Matikainen, M., Smith, J., Koivisto, P., Baffoe-Bonnie, A., Kainu, T., Gillanders, E., Sankila, R., Pukkala, E., Carpten, J., Stephan, D., Tammela, T., Brownstein, M., Bailey-Wilson, J., Trent, J., Kallioniemi, O.P. Clin. Cancer Res. (2000) [Pubmed]
  21. A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region. Baffoe-Bonnie, A.B., Smith, J.R., Stephan, D.A., Schleutker, J., Carpten, J.D., Kainu, T., Gillanders, E.M., Matikainen, M., Teslovich, T.M., Tammela, T., Sood, R., Balshem, A.M., Scarborough, S.D., Xu, J., Isaacs, W.B., Trent, J.M., Kallioniemi, O.P., Bailey-Wilson, J.E. Hum. Genet. (2005) [Pubmed]
  22. Analysis of HPC1, HPCX, and PCaP in Icelandic hereditary prostate cancer. Bergthorsson, J.T., Johannesdottir, G., Arason, A., Benediktsdottir, K.R., Agnarsson, B.A., Bailey-Wilson, J.E., Gillanders, E., Smith, J., Trent, J., Barkardottir, R.B. Hum. Genet. (2000) [Pubmed]
  23. Mechanisms of acquired androgen independence during arsenic-induced malignant transformation of human prostate epithelial cells. Benbrahim-Tallaa, L., Webber, M.M., Waalkes, M.P. Environ. Health Perspect. (2007) [Pubmed]
  24. Putrescine-1,4-dicinnamide from Pholiota spumosa (Basidiomycetes) inhibits cell growth of human prostate cancer cells. Russo, A., Piovano, M., Clericuzio, M., Lombardo, L., Tabasso, S., Chamy, M.C., Vidari, G., Cardile, V., Vita-Finzi, P., Garbarino, J.A. Phytomedicine (2007) [Pubmed]
  25. Dendritic cells program non-immunogenic prostate-specific T cell responses beginning at early stages of prostate tumorigenesis. Mihalyo, M.A., Hagymasi, A.T., Slaiby, A.M., Nevius, E.E., Adler, A.J. Prostate (2007) [Pubmed]
  26. IFI16 in Human Prostate Cancer. Alimirah, F., Chen, J., Davis, F.J., Choubey, D. Mol. Cancer Res. (2007) [Pubmed]
  27. Circumventing anti-androgen resistance by molecular design. McGinley, P.L., Koh, J.T. J. Am. Chem. Soc. (2007) [Pubmed]
  28. Ten-year survival and cardiovascular mortality in patients with advanced prostate cancer primarily treated by intramuscular polyestradiol phosphate or orchiectomy. Mikkola, A., Aro, J., Rannikko, S., Ruutu, M. Prostate (2007) [Pubmed]
  29. Does PSA play a role as a promoting agent during the initiation and/or progression of prostate cancer? Williams, S.A., Singh, P., Isaacs, J.T., Denmeade, S.R. Prostate (2007) [Pubmed]
  30. Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase. Yoshida, L.S., Saruta, F., Yoshikawa, K., Tatsuzawa, O., Tsunawaki, S. J. Biol. Chem. (1998) [Pubmed]
  31. Tyrosine Kinase Etk/BMX Is Up-regulated in Human Prostate Cancer and Its Overexpression Induces Prostate Intraepithelial Neoplasia in Mouse. Dai, B., Kim, O., Xie, Y., Guo, Z., Xu, K., Wang, B., Kong, X., Melamed, J., Chen, H., Bieberich, C.J., Borowsky, A.D., Kung, H.J., Wei, G., Ostrowski, M.C., Brodie, A., Qiu, Y. Cancer Res. (2006) [Pubmed]
  32. A regional localisation for an X-linked suppressor gene (XS) for the Lutheran blood group. Mulley, J.C., Norman, P.C., Tippett, P., Beal, R.W. Hum. Genet. (1988) [Pubmed]
  33. Novel thyrotropin receptor germline mutation (Ile568Val) in a Saxonian family with hereditary nonautoimmune hyperthyroidism. Claus, M., Maier, J., Paschke, R., Kujat, C., Stumvoll, M., Führer, D. Thyroid (2005) [Pubmed]
  34. X-linked genetic factors regulate hematopoietic stem-cell kinetics in females. Christensen, K., Kristiansen, M., Hagen-Larsen, H., Skytthe, A., Bathum, L., Jeune, B., Andersen-Ranberg, K., Vaupel, J.W., Orstavik, K.H. Blood (2000) [Pubmed]
  35. Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia. Monreal, A.W., Ferguson, B.M., Headon, D.J., Street, S.L., Overbeek, P.A., Zonana, J. Nat. Genet. (1999) [Pubmed]
  36. A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast. Laporte, J., Hu, L.J., Kretz, C., Mandel, J.L., Kioschis, P., Coy, J.F., Klauck, S.M., Poustka, A., Dahl, N. Nat. Genet. (1996) [Pubmed]
  37. X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene. Jouet, M., Rosenthal, A., Armstrong, G., MacFarlane, J., Stevenson, R., Paterson, J., Metzenberg, A., Ionasescu, V., Temple, K., Kenwrick, S. Nat. Genet. (1994) [Pubmed]
  38. X-linked situs abnormalities result from mutations in ZIC3. Gebbia, M., Ferrero, G.B., Pilia, G., Bassi, M.T., Aylsworth, A., Penman-Splitt, M., Bird, L.M., Bamforth, J.S., Burn, J., Schlessinger, D., Nelson, D.L., Casey, B. Nat. Genet. (1997) [Pubmed]
  39. Clinicopathologic features of BRCA-linked and sporadic ovarian cancer. Boyd, J., Sonoda, Y., Federici, M.G., Bogomolniy, F., Rhei, E., Maresco, D.L., Saigo, P.E., Almadrones, L.A., Barakat, R.R., Brown, C.L., Chi, D.S., Curtin, J.P., Poynor, E.A., Hoskins, W.J. JAMA (2000) [Pubmed]
  40. Development of a tissue engineered human prostate tumor equivalent for use in the evaluation of cryoablative techniques. Robilotto, A.T., Clarke, D., Baust, J.M., Van Buskirk, R.G., Gage, A.A., Baust, J.G. Technol. Cancer Res. Treat. (2007) [Pubmed]
  41. Suicide Gene Therapy With Adenoviral Delivery of HSV-tK Gene for Patients With Local Recurrence of Prostate Cancer After Hormonal Therapy. Nasu, Y., Saika, T., Ebara, S., Kusaka, N., Kaku, H., Abarzua, F., Manabe, D., Thompson, T.C., Kumon, H. Mol. Ther. (2007) [Pubmed]
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