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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A permease-oxidase complex involved in high-affinity iron uptake in yeast.

Iron must cross biological membranes to reach essential intracellular enzymes. Two proteins in the plasma membrane of yeast--a multicopper oxidase, encoded by the FET3 gene, and a permease, encoded by the FTR1 gene--were shown to mediate high-affinity iron uptake. FET3 expression was required for FTR1 protein to be transported to the plasma membrane. FTR1 expression was required for apo-FET3 protein to be loaded with copper and thus acquire oxidase activity. FTR1 protein also played a direct role in iron transport. Mutations in a conserved sequence motif of FTR1 specifically blocked iron transport.[1]

References

  1. A permease-oxidase complex involved in high-affinity iron uptake in yeast. Stearman, R., Yuan, D.S., Yamaguchi-Iwai, Y., Klausner, R.D., Dancis, A. Science (1996) [Pubmed]
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