The effect of BCG on experimental cutaneous leishmaniasis in mice.
The effect of administration of live Bacillus Calmette-Guerin (BCG), a nonspecific immunostimulant, on the course of experimental cutaneous leishmaniasis in mice was investigated. BALB/c mice were injected in the footpad with Leishmania tropica, NIH S-strain; in mice that were not pretreated with BCG this produced a reproducible fatal infection characterized by local inflammation, regional lymphadenopathy, and dissemination of parasites with hepatosplenomegaly. In mice that were pretreated with BCG and similarly infected with L. tropica there was a reduction in the severity of cutaneous disease and a significant (p less than 0.005) decrease in mortality without evidence of visceralization.[1]References
- The effect of BCG on experimental cutaneous leishmaniasis in mice. Weintraub, J., Weinbaum, F.I. J. Immunol. (1977) [Pubmed]
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