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MeSH Review

Lymphatic Diseases

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Disease relevance of Lymphatic Diseases


Psychiatry related information on Lymphatic Diseases


High impact information on Lymphatic Diseases

  • Hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS; MIM 260920) is a rare, apparently monogenic, autosomal recessive disorder characterized by recurrent episodes of fever accompanied with lymphadenopathy, abdominal distress, joint involvement and skin lesions [7].
  • Most patients also had increased appetite and weight, decreased lymphadenopathy and hepatosplenomegaly, decreased immunoglobulin levels, and increased numbers of CD4 cells [8].
  • The asymptomatic and otherwise healthy T4 epitope-deficient brother of one of these patients also had lymphadenopathy in a distribution identical to that of his sister with SLE [9].
  • Mice that are homozygous for either the lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) mutant genes develop a disease characterized by massive lymphadenopathy and autoantibody formation [10].
  • Antibody to LAV p25 was found in the serum of 51 of 125 AIDS patients, 81 of 113 patients with lymphadenopathy syndrome, 0 of 70 workers at the Centers for Disease Control (some of whom had handled specimens from AIDS patients), and 0 of 189 random blood donors [11].

Chemical compound and disease context of Lymphatic Diseases


Biological context of Lymphatic Diseases

  • In January 1982, the Centers for Disease Control began a prospective study of unexplained generalized lymphadenopathy syndrome in 78 homosexual or bisexual men [17].
  • These modifications preceded the lymphadenopathy, because early progenitors (colony-forming units-spleen [CFU-S] day 8) were already augmented in day-18 fetal livers of the lpr phenotype [18].
  • lpr, a murine mutation of the Fas apoptosis receptor, causes lymphadenopathy and autoantibody production, with lymphadenopathy primarily due to a population of CD4-CD8-B220+ T cells [19].
  • We find that in MRL-lpr/lpr mice bearing the CK2alpha transgene, the lymphoproliferative process is dramatically exacerbated, as these mice develop massive splenomegaly and lymphadenopathy by 12 wk of age in association with increased autoantibody production and accelerated renal disease [20].
  • Along the same line, administration of either F23.1 or two different anti-F23.1 anti-idiotypic antibodies to MRL/Mp-lpr/lpr mothers elicited, in the offspring, the production of antibodies sharing a recurrent idiotype with F23.1 and resulted in long-term amelioration of autoimmunity and lymphadenopathy [21].

Anatomical context of Lymphatic Diseases


Gene context of Lymphatic Diseases

  • Both IFN-gamma -/- and IL-4 -/- mice, however, developed significantly reduced lymphadenopathy and end-organ disease [27].
  • Here we show that, in patients with lymphadenopathy, autocrine VEGF and alpha(4)beta(1) integrin are involved in the chemokine-dependent motility of CLL cells on and through endothelium-processes important for the invasion of lymphoreticular tissues, a major determinant of disease outcome [28].
  • Lymphadenopathy and other disease manifestations were greatly reduced in Fyn-/- lpr mice concomitant to decreased DN cells (from 77 to 20%) [29].
  • Increased levels of interleukin-6 (IL-6) in serum and spontaneous in vitro production of IL-6 by lymph node mononuclear cells of patients with angio-immunoblastic lymphadenopathy with dysproteinemia (AILD), and clinical effectiveness of cyclosporin A [30].
  • In addition, the migration index of B-CLL cells in response to both of the CCR7 ligands correlated with the presence of clinical lymphadenopathy, thus indicating that the high expression of functional chemokine receptors justifies the widespread character of B-CLL, representing a clinical target for the control of tumor cell dissemination [31].

Analytical, diagnostic and therapeutic context of Lymphatic Diseases


  1. Lymphadenopathy associated virus infection of a blood donor--recipient pair with acquired immunodeficiency syndrome. Feorino, P.M., Kalyanaraman, V.S., Haverkos, H.W., Cabradilla, C.D., Warfield, D.T., Jaffe, H.W., Harrison, A.K., Gottlieb, M.S., Goldfinger, D., Chermann, J.C. Science (1984) [Pubmed]
  2. Zomepirac-induced serum sickness. A report of two cases. Kiani, R., Kushner, M. JAMA (1983) [Pubmed]
  3. Increased porphobilinogen deaminase activity in patients with malignant lymphoproliferative diseases. A helpful diagnostic test. Lahav, M., Epstein, O., Schoenfeld, N., Shaklai, M., Atsmon, A. JAMA (1987) [Pubmed]
  4. Antiproliferative and antitumor activity of the 2-cyanoaziridine compound imexon on tumor cell lines and fresh tumor cells in vitro. Hersh, E.M., Gschwind, C.R., Taylor, C.W., Dorr, R.T., Taetle, R., Salmon, S.E. J. Natl. Cancer Inst. (1992) [Pubmed]
  5. Diagnosis and staging of hepatocellular carcinoma. Talwalkar, J.A., Gores, G.J. Gastroenterology (2004) [Pubmed]
  6. Acute granulomatous interstitial nephritis and colitis in anticonvulsant hypersensitivity syndrome associated with lamotrigine treatment. Fervenza, F.C., Kanakiriya, S., Kunau, R.T., Gibney, R., Lager, D.J. Am. J. Kidney Dis. (2000) [Pubmed]
  7. Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group. Drenth, J.P., Cuisset, L., Grateau, G., Vasseur, C., van de Velde-Visser, S.D., de Jong, J.G., Beckmann, J.S., van der Meer, J.W., Delpech, M. Nat. Genet. (1999) [Pubmed]
  8. Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection. Pizzo, P.A., Eddy, J., Falloon, J., Balis, F.M., Murphy, R.F., Moss, H., Wolters, P., Brouwers, P., Jarosinski, P., Rubin, M. N. Engl. J. Med. (1988) [Pubmed]
  9. Systemic lupus erythematosus with deficiency of the T4 epitope on T helper/inducer cells. Stohl, W., Crow, M.K., Kunkel, H.G. N. Engl. J. Med. (1985) [Pubmed]
  10. Abnormal tyrosine phosphorylation on T-cell receptor in lymphoproliferative disorders. Samelson, L.E., Davidson, W.F., Morse, H.C., Klausner, R.D. Nature (1986) [Pubmed]
  11. Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS. Kalyanaraman, V.S., Cabradilla, C.D., Getchell, J.P., Narayanan, R., Braff, E.H., Chermann, J.C., Barré-Sinoussi, F., Montagnier, L., Spira, T.J., Kaplan, J. Science (1984) [Pubmed]
  12. Editorial: Lymphadenopathy induced by diphenylhydantoin. Hussey, H.H. JAMA (1975) [Pubmed]
  13. Prednisone in treatment of allergen-associated angio-immunoblastic lymphadenopathy. Newcom, S.R., Kadin, M.E. Lancet (1979) [Pubmed]
  14. Regression of chronic generalised lymphadenopathy in a homosexual man after therapy with intravenous acyclovir. Resnick, L., Rosen, L., Horwitz, S., Frost, P. Lancet (1984) [Pubmed]
  15. Letter: Levamisole in angio-immunoblastic lymphadenopathy. Bensa, J., Faure, J., Martin, H., Sotto, J., Schaerer, R. Lancet (1976) [Pubmed]
  16. Sulindac causing a hypersensitivity reaction with peripheral and mediastinal lymphadenopathy. Sprung, D.J. Ann. Intern. Med. (1982) [Pubmed]
  17. Unexplained lymphadenopathy in homosexual men. A longitudinal study. Fishbein, D.B., Kaplan, J.E., Spira, T.J., Miller, B., Schonberger, L.B., Pinsky, P.F., Getchell, J.P., Kalyanaraman, V.S., Braude, J.S. JAMA (1985) [Pubmed]
  18. Increased fetal and extramedullary hematopoiesis in Fas-deficient C57BL/6-lpr/lpr mice. Schneider, E., Moreau, G., Arnould, A., Vasseur, F., Khodabaccus, N., Dy, M., Ezine, S. Blood (1999) [Pubmed]
  19. Novel immunoregulatory B cell pathways revealed by lpr-+ mixed chimeras. Sobel, E.S., Kakkanaiah, V.N., Schiffenbauer, J., Reap, E.A., Cohen, P.L., Eisenberg, R.A. J. Immunol. (1998) [Pubmed]
  20. Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. Rifkin, I.R., Channavajhala, P.L., Kiefer, H.L., Carmack, A.J., Landesman-Bollag, E., Beaudette, B.C., Jersky, B., Salant, D.J., Ju, S.T., Marshak-Rothstein, A., Seldin, D.C. J. Immunol. (1998) [Pubmed]
  21. Attenuation of autoimmune disease and lymphocyte accumulation in MRL/lpr mice by treatment with anti-V beta 8 antibodies. de Alborán, I.M., Gonzalo, J.A., Kroemer, G., Leonardo, E., Marcos, M.A., Martínez, C. Eur. J. Immunol. (1992) [Pubmed]
  22. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Swat, W., Fujikawa, K., Ganiatsas, S., Yang, D., Xavier, R.J., Harris, N.L., Davidson, L., Ferrini, R., Davis, R.J., Labow, M.A., Flavell, R.A., Zon, L.I., Alt, F.W. Immunity (1998) [Pubmed]
  23. Transgenic rearranged T cell receptor gene inhibits lymphadenopathy and accumulation of CD4-CD8-B220+ T cells in lpr/lpr mice. Mountz, J.D., Zhou, T., Eldridge, J., Berry, K., Blüthmann, H. J. Exp. Med. (1990) [Pubmed]
  24. Expression of cell-homologous genes of human herpesvirus-8 in human immunodeficiency virus-negative lymphoproliferative diseases. Luppi, M., Barozzi, P., Maiorana, A., Trovato, R., Marasca, R., Morselli, M., Cagossi, K., Torelli, G. Blood (1999) [Pubmed]
  25. HTLV-III/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS. Tenner-Racz, K., Racz, P., Bofill, M., Schulz-Meyer, A., Dietrich, M., Kern, P., Weber, J., Pinching, A.J., Veronese-Dimarzo, F., Popovic, M. Am. J. Pathol. (1986) [Pubmed]
  26. CD4+ subset regulation in viral infection. Preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice. Gazzinelli, R.T., Makino, M., Chattopadhyay, S.K., Snapper, C.M., Sher, A., Hügin, A.W., Morse, H.C. J. Immunol. (1992) [Pubmed]
  27. Roles of interferon-gamma and interleukin-4 in murine lupus. Peng, S.L., Moslehi, J., Craft, J. J. Clin. Invest. (1997) [Pubmed]
  28. CLL, but not normal, B cells are dependent on autocrine VEGF and alpha4beta1 integrin for chemokine-induced motility on and through endothelium. Till, K.J., Spiller, D.G., Harris, R.J., Chen, H., Zuzel, M., Cawley, J.C. Blood (2005) [Pubmed]
  29. The proliferative in vivo activities of lpr double-negative T cells and the primary role of p59fyn in their activation and expansion. Balomenos, D., Rumold, R., Theofilopoulos, A.N. J. Immunol. (1997) [Pubmed]
  30. Increased levels of interleukin-6 (IL-6) in serum and spontaneous in vitro production of IL-6 by lymph node mononuclear cells of patients with angio-immunoblastic lymphadenopathy with dysproteinemia (AILD), and clinical effectiveness of cyclosporin A. Yamamura, M., Honda, M., Yamada, Y., Itoyama, T., Sohda, H., Yubashi, T., Momita, S., Kamihira, S., Ohmoto, Y., Tomonaga, M. Leukemia (1996) [Pubmed]
  31. Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination. López-Giral, S., Quintana, N.E., Cabrerizo, M., Alfonso-Pérez, M., Sala-Valdés, M., De Soria, V.G., Fernández-Rañada, J.M., Fernández-Ruiz, E., Muñoz, C. J. Leukoc. Biol. (2004) [Pubmed]
  32. Sarcoidosis of the heart. Swanton, R.H. Eur. Heart J. (1988) [Pubmed]
  33. Uptake of fluorine-18-fluorodeoxyglucose in sarcoidosis. Lewis, P.J., Salama, A. J. Nucl. Med. (1994) [Pubmed]
  34. Massive macrophage lipid accumulation presenting as hepatosplenomegaly and lymphadenopathy associated with long-term total parenteral nutrition therapy for short bowel syndrome. Perez-Jaffe, L.A., Furth, E.E., Minda, J.M., Unger, L.D., Lawton, T.J. Hum. Pathol. (1998) [Pubmed]
  35. Genotypic prognostic markers. Stilgenbauer, S., Döhner, H. Curr. Top. Microbiol. Immunol. (2005) [Pubmed]
  36. Elevated germ cell markers in carcinoma of uncertain primary site do not predict response to platinum based chemotherapy. Currow, D.C., Findlay, M., Cox, K., Harnett, P.R. Eur. J. Cancer (1996) [Pubmed]
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