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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ischemia-induced migraine from paradoxical cardioembolic stroke.

Although little is known on the pathophysiologic mechanism of migraine-related stroke, the prevailing attitude is that vasoconstriction and activation of clotting factors play a primary role. In 2 female patients presenting with migraine and stroke, risk profiles and history were consistent with this pathophysiologic mechanism. Cerebro- and cardiovascular workup, however, led to a diagnosis of paradoxical cardioembolic stroke through a patent foramen ovale. Since there is hardly any evidence in the literature that migraine acts as a risk factor for stroke on its own, these case reports emphasize the importance of complete cardiovascular evaluation in patients with suspected migrainous stroke.[1]


  1. Ischemia-induced migraine from paradoxical cardioembolic stroke. Ries, S., Steinke, W., Neff, W., Schindlmayr, C., Meairs, S., Hennerici, M. Eur. Neurol. (1996) [Pubmed]
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