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Chemical Compound Review

suloctidil     2-(octylamino)-1-(4-propan- 2...

Synonyms: Bemperil, Farectil, Sulocton, Sulodene, Cerebro, ...
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Disease relevance of suloctidil


Psychiatry related information on suloctidil


High impact information on suloctidil

  • Clark et al. conclude from their analysis of volumetric brain proportions ("cerebro-types") that cerebellum size is invariant across mammalian taxonomic groups, the neocortex and cerebellum do not co-vary in size (in contradiction to ref. 1), and cerebrotype-based measures identify directional changes in brain architecture [11].
  • Elevated blood pressure is an important risk factor for renal-, cerebro- and cardiovascular diseases [12].
  • The gamma band (26-40 Hz) showed strongest modulation for cerebro-muscular coherence and was strongest for the isometric contraction conditions [13].
  • This study specifically addresses the issues of (i) task-relatedness, (ii) hemispheric symmetry, and (iii) frequency specificity of the measures power, cerebro-muscular coherence, and cerebro-cerebral coherence in bilateral primary motor cortex and supplementary motor area (SMA) [13].
  • Power, cerebro-musclar coherence, and cerebro-cerebral coherence between these areas were computed for four frequency bands in each condition and subjected to ANOVA [13].

Chemical compound and disease context of suloctidil


Biological context of suloctidil


Anatomical context of suloctidil

  • These results imply that an intact cerebro-basal ganglia loop is essential for awareness of limb position and suggest a selective role of the basal ganglia but not the cerebellum in kinaesthesia [24].
  • Effects of suloctidil on platelet survival time following cardiac valve replacement [25].
  • Mortality, cerebro- or cardiovascular events, amputations, arterial occlusions or number of revascularization procedures performed in the lower limbs, pain-free and total walking distance, ankle brachial index and calf blood flow, were the main outcomes considered [26].
  • The effects of small doses are attributed to a local action in the brainstem which causes inhibition of spinal neurones either by activating descending inhibitory neuronal systems or by liberating endogenous substances which reach the spinal cord via the cerebro-spinal fluid [27].
  • This point kernel approach was used in combination with a distance histogram technique, to study in more detail the absorbed dose distribution in the cerebro-spinal fluid, in the surface of the central nervous system, and in tumor sites [28].

Associations of suloctidil with other chemical compounds


Gene context of suloctidil


Analytical, diagnostic and therapeutic context of suloctidil

  • Using a recently developed analysis tool (Dynamic Imaging of Coherent Sources; DICS), we determined cerebro-muscular and cerebro-cerebral coherence as well as the partial coherence between cerebral areas and muscle, and localized coherent sources within the individual MRI scans [39].
  • The results after oral administration of suloctidil (100 mg/kg/d in two divided doses) were not different from control studies [4].
  • Cannula platelet consumption was unaffected by suloctidil (20 mg/kg/d given in two divided doses for two days preceding and throughout the period of platelet survival measurement) [4].
  • A double blind cross over study with suloctidil (Sulocton, Continental Pharma) and placebo was carried out for 6 months in 31 patients with idiopathic recurrent vein thrombosis [40].
  • Cerebro-cortical laser-Doppler flow (cortical perfusion, CP), arterial blood pressure, core temperature, PaO2, PaCO2, pH and glycemia were measured before, during and after MCAO [41].


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  14. Reduction in cerebral ischemic injury in the newborn rat by potentiation of endogenous adenosine. Gidday, J.M., Fitzgibbons, J.C., Shah, A.R., Kraujalis, M.J., Park, T.S. Pediatr. Res. (1995) [Pubmed]
  15. L-Asparagine depletion in plasma and cerebro-spinal fluid of children with acute lymphoblastic leukemia during subsequent exposures to Erwinia L-asparaginase. Gentili, D., Conter, V., Rizzari, C., Tschuemperlin, B., Zucchetti, M., Orlandoni, D., D'Incalci, M., Masera, G. Ann. Oncol. (1996) [Pubmed]
  16. Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87. Meldrum, B.S., Swan, J.H., Leach, M.J., Millan, M.H., Gwinn, R., Kadota, K., Graham, S.H., Chen, J., Simon, R.P. Brain Res. (1992) [Pubmed]
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  19. Spinal cord metastasis in small cell carcinoma of the lung. Holoye, P., Libnoch, J., Cox, J., Kun, L., Byhardt, R., Almagro, U., McClelland, S., Chintapali, K. Int. J. Radiat. Oncol. Biol. Phys. (1984) [Pubmed]
  20. Neuronal plasticity of interrelated cerebellar and cortical networks. Molinari, M., Filippini, V., Leggio, M.G. Neuroscience (2002) [Pubmed]
  21. Effect of suloctidil on Na+/K+ ATPase activity and on membrane fluidity in rat brain synaptosomes. Chatelain, P., Reckinger, N., Roncucci, R. Biochem. Pharmacol. (1979) [Pubmed]
  22. Effects of cerebro-protective agents on enzyme activities of rat primary glial cultures and rat cerebral cortex. Bielenberg, G.W., Hayn, C., Krieglstein, J. Biochem. Pharmacol. (1986) [Pubmed]
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  24. Dysfunction of the basal ganglia, but not the cerebellum, impairs kinaesthesia. Maschke, M., Gomez, C.M., Tuite, P.J., Konczak, J. Brain (2003) [Pubmed]
  25. Effects of suloctidil on platelet survival time following cardiac valve replacement. Col-de Beys, C., Ferrant, A., Moriau, M. Thromb. Haemost. (1981) [Pubmed]
  26. Antithrombotic drugs in the primary medical management of intermittent claudication: a meta-analysis. Girolami, B., Bernardi, E., Prins, M.H., ten Cate, J.W., Prandoni, P., Hettiarachchi, R., Marras, E., Stefani, P.M., Girolami, A., Büller, H.R. Thromb. Haemost. (1999) [Pubmed]
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  28. A dosimetric model for intrathecal treatment with 131I and 67Ga. van Dieren, E.B., van Lingen, A., Roos, J.C., Huijgens, P.C., Barendsen, G.W., Teule, G.J. Int. J. Radiat. Oncol. Biol. Phys. (1994) [Pubmed]
  29. Stimulation of prostacyclin production in blood vessels by the antithrombotic drug suloctidil. Boeynaems, J.M., Van Coevorden, A., Demolle, D. Biochem. Pharmacol. (1987) [Pubmed]
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  35. Serum amyloid P component induces neuronal apoptosis and beta-amyloid immunoreactivity. Urbányi, Z., László, L., Tomasi, T.B., Tóth, E., Mekes, E., Sass, M., Pázmány, T. Brain Res. (2003) [Pubmed]
  36. Distribution of plasma membrane Ca2+ pump (PMCA) isoforms in the gerbil brain: effect of ischemia-reperfusion injury. Lehotský, J., Kaplán, P., Racay, P., Mézesová, V., Raeymaekers, L. Neurochem. Int. (1999) [Pubmed]
  37. No contractile effect for 5-HT1D and 5-HT1F receptor agonists in human and bovine cerebral arteries: similarity with human coronary artery. Bouchelet, I., Case, B., Olivier, A., Hamel, E. Br. J. Pharmacol. (2000) [Pubmed]
  38. Influence of thyroid hormones on somatostatin processing in cultured cerebro-cortical cells. de los Frailes, M.T., Sanchez Franco, F., Lorenzo, M.J., Tolón, R., Cacicedo, L. Neuropeptides (1990) [Pubmed]
  39. The cerebral oscillatory network of parkinsonian resting tremor. Timmermann, L., Gross, J., Dirks, M., Volkmann, J., Freund, H.J., Schnitzler, A. Brain (2003) [Pubmed]
  40. Clinical and biological activity of the antiplatelet agent suloctidil in treatment of idiopathic recurrent vein thrombosis (I.R.V.T.). Moriau, M., Col-De Beys, C., Pardonge, E., Ferrant, A. Thromb. Haemost. (1982) [Pubmed]
  41. Dietary phytoestrogens improve stroke outcome after transient focal cerebral ischemia in rats. Burguete, M.C., Torregrosa, G., Pérez-Asensio, F.J., Castelló-Ruiz, M., Salom, J.B., Gil, J.V., Alborch, E. Eur. J. Neurosci. (2006) [Pubmed]
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