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MeSH Review

Heart Septal Defects, Atrial

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Disease relevance of Heart Septal Defects, Atrial


High impact information on Heart Septal Defects, Atrial


Chemical compound and disease context of Heart Septal Defects, Atrial

  • METHODS: The Patent foramen ovale In Cryptogenic Stroke Study (PICSS) evaluated transesophageal echocardiography findings in patients enrolled in the Warfarin-Aspirin Recurrent Stroke Study, a randomized double-blind trial to evaluate the efficacy of warfarin compared with aspirin [11].
  • The defects were easily visualized in all patients using a long axis vena cava superior-inferior plane with a subcostal approach, while the atrial septum seemed to be intact in the coronal plane conventionally used for atrial septal defects of the primum or secundum type [12].
  • This laser catheter system, capable of transmitting several watts of pulsed CO2 laser energy, was initially used to create atrial septal defects in isolated dog hearts to determine the best energy parameters [13].
  • BACKGROUND: Aspirin has been routinely prescribed following transcatheter closure of secundum atrial septal defects (ASDs) but its rationale has not been clinically or biologically evaluated; and despite aspirin, thrombotic complications occur following transcatheter ASD closure [14].
  • Cerebro- and cardiovascular workup, however, led to a diagnosis of paradoxical cardioembolic stroke through a patent foramen ovale [15].

Biological context of Heart Septal Defects, Atrial


Anatomical context of Heart Septal Defects, Atrial


Gene context of Heart Septal Defects, Atrial

  • The cardiac transcription factor GATA4 has not previously been implicated in a human disorder but a recent paper by Garg et al. provides evidence of mutations in GATA4 that cause atrial septal defects [26].
  • Mutations in TBX5 have already been shown to cause similar atrial septal defects in Holt-Oram syndrome [26].
  • Further trends towards higher frequencies of the FVL mutation were found in patients with patent foramen ovale (OR 1.9), individual (OR 2.1) or family history of previous thrombembolisms (OR 2.0), and in those aged 25 years at onset of disease (OR 1.9, all not significant) [27].
  • Although ASD occurred only rarely, atrial septal dysmorphogenesis was evident as increased frequencies of patent foramen ovale and septal aneurysm, and decreased length of the septum primum flap valve [28].
  • Transcatheter closure of atrial septal defects. Past, present, and future [29].

Analytical, diagnostic and therapeutic context of Heart Septal Defects, Atrial


  1. Chromosome 3 duplication q21 leads to qter deletion p25 leads to pter syndrome in children of carriers of a pericentric inversion inv(3) (p25q21). Allderdice, P.W., Browne, N., Murphy, D.P. Am. J. Hum. Genet. (1975) [Pubmed]
  2. Chiari's network: normal anatomic variant or risk factor for arterial embolic events? Schneider, B., Hofmann, T., Justen, M.H., Meinertz, T. J. Am. Coll. Cardiol. (1995) [Pubmed]
  3. Atrial right-to-left shunting causing severe hypoxaemia despite normal right-sided pressures. Report of 11 consecutive cases corrected by percutaneous closure. Godart, F., Rey, C., Prat, A., Vincentelli, A., Chmaït, A., Francart, C., Porte, H. Eur. Heart J. (2000) [Pubmed]
  4. Patent foramen ovale and brain infarct. Echocardiographic predictors, recurrence, and prevention. Hanna, J.P., Sun, J.P., Furlan, A.J., Stewart, W.J., Sila, C.A., Tan, M. Stroke (1994) [Pubmed]
  5. Ruptured aneurysms of the sinus of Valsalva. Mayer, E.D., Ruffmann, K., Saggau, W., Butzmann, B., Bernhardt-Mayer, K., Schatton, N., Schmitz, W. Ann. Thorac. Surg. (1986) [Pubmed]
  6. Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. Benson, D.W., Silberbach, G.M., Kavanaugh-McHugh, A., Cottrill, C., Zhang, Y., Riggs, S., Smalls, O., Johnson, M.C., Watson, M.S., Seidman, J.G., Seidman, C.E., Plowden, J., Kugler, J.D. J. Clin. Invest. (1999) [Pubmed]
  7. Images in Cardiovascular Medicine. Left-sided ablation via a patent foramen ovale. Ewer, S.N., Kocheril, A.G. Circulation (1998) [Pubmed]
  8. Transvenous closure of secundum atrial septal defects: preliminary results with a new self-expanding nitinol prosthesis in a swine model. Sharafuddin, M.J., Gu, X., Titus, J.L., Urness, M., Cervera-Ceballos, J.J., Amplatz, K. Circulation (1997) [Pubmed]
  9. Atrial septal aneurysm in adult patients. A multicenter study using transthoracic and transesophageal echocardiography. Mügge, A., Daniel, W.G., Angermann, C., Spes, C., Khandheria, B.K., Kronzon, I., Freedberg, R.S., Keren, A., Denning, K., Engberding, R. Circulation (1995) [Pubmed]
  10. Blade balloon atrial septostomy in patients with severe primary pulmonary hypertension. Kerstein, D., Levy, P.S., Hsu, D.T., Hordof, A.J., Gersony, W.M., Barst, R.J. Circulation (1995) [Pubmed]
  11. Atrial anatomy in non-cardioembolic stroke patients: effect of medical therapy. Homma, S., Sacco, R.L., Di Tullio, M.R., Sciacca, R.R., Mohr, J.P. J. Am. Coll. Cardiol. (2003) [Pubmed]
  12. Detection of sinus venosus atrial septal defect by two-dimensional echocardiography. Mühler, E.G., Engelhardt, W., von Bernuth, G. Eur. Heart J. (1992) [Pubmed]
  13. The use of carbon dioxide fiberoptic laser catheter for atrial septostomy. Zeevi, B., Gal, D., Wolf, N., Berant, M., Abramovici, A., Blieden, L.C., Katzir, A. Am. Heart J. (1988) [Pubmed]
  14. Assessment of the markers of platelet and coagulation activation following transcatheter closure of atrial septal defects. Rodés-Cabau, J., Palacios, A., Palacio, C., Girona, J., Galve, E., Evangelista, A., Casaldáliga, J., Albert, D., Picó, M., Soler-Soler, J. International journal of cardiology. (2005) [Pubmed]
  15. Ischemia-induced migraine from paradoxical cardioembolic stroke. Ries, S., Steinke, W., Neff, W., Schindlmayr, C., Meairs, S., Hennerici, M. Eur. Neurol. (1996) [Pubmed]
  16. Increased prevalence of patent foramen ovale in patients with severe chronic obstructive pulmonary disease. Soliman, A., Shanoudy, H., Liu, J., Russell, D.C., Jarmukli, N.F. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. (1999) [Pubmed]
  17. Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse. Kirk, E.P., Hyun, C., Thomson, P.C., Lai, D., Castro, M.L., Biben, C., Buckley, M.F., Martin, I.C., Moran, C., Harvey, R.P. Circ. Res. (2006) [Pubmed]
  18. Cases from the aerospace medicine residents' teaching file. Transient ischemic attack in an aviator with patent foramen ovale and Factor V Leiden. Radimer, M.C. Aviation, space, and environmental medicine. (2003) [Pubmed]
  19. Congenital extracardial malformations accompanying congenital heart disease. Gallo, P., Nardi, F., Marinozzi, V. Giornale italiano di cardiologia. (1976) [Pubmed]
  20. Gas exchange detection of exercise-induced right-to-left shunt in patients with primary pulmonary hypertension. Sun, X.G., Hansen, J.E., Oudiz, R.J., Wasserman, K. Circulation (2002) [Pubmed]
  21. Maternal and fetal outcome in pregnant women with Eisenmenger's syndrome. Avila, W.S., Grinberg, M., Snitcowsky, R., Faccioli, R., Da Luz, P.L., Bellotti, G., Pileggi, F. Eur. Heart J. (1995) [Pubmed]
  22. Left heart lesions in patients with Ebstein anomaly. Attenhofer Jost, C.H., Connolly, H.M., O'Leary, P.W., Warnes, C.A., Tajik, A.J., Seward, J.B. Mayo Clin. Proc. (2005) [Pubmed]
  23. Atypical hypoplastic left ventricular syndrome in a calf. Lemberger, K.Y., Mohr, K.R., Andrews, J.J. J. Vet. Diagn. Invest. (2004) [Pubmed]
  24. Transient platypnea-orthodeoxia-like syndrome induced by propafenone overdose in a young woman with Ebstein's anomaly. Pavoni, D., Ragazzo, S., Driussi, M., Antonini-Canterin, F., Pavan, D., Zardo, F., Nicolosi, G.L. Italian heart journal : official journal of the Italian Federation of Cardiology. (2003) [Pubmed]
  25. Infradiaphragmatic total anomalous pulmonary venous return. Review of clinical and pathological findings and results of operation in 28 cases. Duff, D.F., Nihill, M.R., McNamara, D.G. British heart journal. (1977) [Pubmed]
  26. Interaction makes the heart grow stronger. Packham, E.A., David Brook, J. Trends in molecular medicine. (2003) [Pubmed]
  27. Prevalence of factor V Leiden mutation in young adults with cerebral ischaemia: a case-control study on 225 patients. Nabavi, D.G., Junker, R., Wolff, E., Lüdemann, P., Doherty, C., Evers, S., Droste, D.W., Kessler, C., Assmann, G., Ringelstein, E.B. J. Neurol. (1998) [Pubmed]
  28. Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5. Biben, C., Weber, R., Kesteven, S., Stanley, E., McDonald, L., Elliott, D.A., Barnett, L., Köentgen, F., Robb, L., Feneley, M., Harvey, R.P. Circ. Res. (2000) [Pubmed]
  29. Transcatheter closure of atrial septal defects. Past, present, and future. Rocchini, A.P. Circulation (1990) [Pubmed]
  30. Paradoxical cerebral embolism: eight cases. Biller, J., Adams, H.P., Johnson, M.R., Kerber, R.E., Toffol, G.J. Neurology (1986) [Pubmed]
  31. Positive contrast echocardiography in patients with patent foramen ovale and normal right heart hemodynamics. Kronik, G., Mösslacher, H. Am. J. Cardiol. (1982) [Pubmed]
  32. Assessment of patient radiation doses during transcatheter closure of ventricular and atrial septal defects with Amplatzer devices. Papadopoulou, D.I., Yakoumakis, E.N., Makri, T.K., Sandilos, P.H., Thanopoulos, B.D., Georgiou, E.K. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. (2005) [Pubmed]
  33. Ventricular septal flattening at end systole falsely predicts right ventricular hypertension in patients with ostium primum atrial septal defects. Nielsen, J.C., Kamenir, S.A., Ko, H.S., Lai, W.W., Parness, I.A. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. (2002) [Pubmed]
  34. Accidental left ventricular placement of a defibrillator probe due to a patent foramen ovale in arrhythmogenic right ventricular dysplasia. Hagenah, G., Andreas, S., Konstantinides, S. Acta cardiologica. (2004) [Pubmed]
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