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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Arrested DNA replication in Xenopus and release by Escherichia coli mutagenesis proteins.

Xenopus oocytes and oocyte nuclear extracts repair ultraviolet photoproducts on double-stranded (ds) DNA and replicate single-stranded (ss) to ds DNA. M13 ss DNA molecules containing cyclobutane pyrimidine dimers were maintained but not replicated in Xenopus oocytes yet were replicated in progesterone-matured oocytes. The replication arrest functioned only in cis. The replication arrest was alleviated by injection into oocytes of messenger RNAs encoding the prokaryotic mutagenesis proteins UmuD'C or MucA'B. These results may help explain how cells stabilize repair or replication events on DNA with unrepairable lesions.[1]

References

  1. Arrested DNA replication in Xenopus and release by Escherichia coli mutagenesis proteins. Oda, N., Levin, J.D., Spoonde, A.Y., Frank, E.G., Levine, A.S., Woodgate, R., Ackerman, E.J. Science (1996) [Pubmed]
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