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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Surgical modulation of the natural course of collateral circulation in chronic ischemic patients.

The purpose of this study was to evaluate hemodynamic compromise in terms of baseline CBF and CRC in patients with chronic cerebral occlusive lesions and its modulation by a superficial temporal artery to middle cerebral artery (STA-MCA) anastomosis. The study subjects were 10 healthy volunteers and 49 chronic ischemic patients with stenosis or occlusion of the internal carotid artery (ICA) or middle cerebral artery (MCA). The hemodynamics were measured using stable xenon enhanced computed tomographic CBF measurement with the acetazolamide challenge. The compromised hemodynamics in patients with chronic steno-occlusive lesions did not improve during their natural course after two months. STA-MCA bypass modulated hemodynamic compromise in the ischemic patients. We recommend STA-MCA bypass for patients with reduced CRC, regardless of whether baseline CBF is reduced or normal. Hemodynamic classification using a combination of baseline CBF values and CRC values is useful for evaluating cerebral hemodynamics and for choosing the best treatment for cerebral ischemia with occlusive lesions.[1]


  1. Surgical modulation of the natural course of collateral circulation in chronic ischemic patients. Yamashita, T., Nakano, S., Ishihara, H., Kitahara, T., Kashiwagi, S., Katoh, S., Takasago, T., Wakuta, Y., Abiko, S., Ito, H. Acta Neurol. Scand., Suppl. (1996) [Pubmed]
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