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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Towards understanding the aetiology and pathophysiology of the emetic reflex: novel approaches to antiemetic drugs.

The introduction of 5-HT3 antagonists, such as ondansetron, as antiemetic agents has transformed the management of patients receiving chemotherapy or radiation therapy. Studies in animal models with NK1 antagonists suggest that these represent a new class of antiemetic agents having a broader spectrum of activity than 5-HT3 antagonists. Compounds of this class may prove to be more effective in man against delayed emesis induced by cisplatin, post-operative nausea and vomiting and motion sickness. Thus, they have the potential to complement 5-HT3 antagonists and so provide a further advance in the management of nausea and vomiting.[1]

References

  1. Towards understanding the aetiology and pathophysiology of the emetic reflex: novel approaches to antiemetic drugs. Bountra, C., Gale, J.D., Gardner, C.J., Jordan, C.C., Kilpatrick, G.J., Twissell, D.J., Ward, P. Oncology (1996) [Pubmed]
 
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