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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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In-vitro evaluation of beta-lactamase inhibition by latamoxef and imipenem.

The in-vitro 50% inhibitory concentrations (IC50s) of latamoxef and imipenem against a set of plasmid-mediated beta-lactamases including TEM-1, TEM-3, TEM-5 and TEM-10 were determined by an enzymatic method using nitrocefin as substrate. The IC50s of both antibiotics against extended-spectrum beta-lactamases were below 0.2 mg/L. The conventional spectrum beta-lactamase TEM-1 was not inhibited by either antibiotic at the highest concentration tested. Except for TEM-10 for which the IC50s of the two antibiotics were the same, imipenem showed significantly greater activity than latamoxef against TEM-3 and TEM-5. Clavulanic acid taken as a control demonstrated greater and wider inhibitory activity, but on the other hand it has no significant antibiotic activity.[1]

References

  1. In-vitro evaluation of beta-lactamase inhibition by latamoxef and imipenem. Sotto, A., Brunschwig, C., O'Callaghan, D., Ramuz, M., Jourdan, J. J. Antimicrob. Chemother. (1996) [Pubmed]
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