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Gene Review

GPR124  -  G protein-coupled receptor 124

Homo sapiens

Synonyms: DKFZp434C211, DKFZp434J0911, FLJ14390, G-protein coupled receptor 124, KIAA1531, ...
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Disease relevance of GPR124


High impact information on GPR124


Chemical compound and disease context of GPR124


Biological context of GPR124

  • Apart from broad spectrum beta-lactamases like SHV 2 or TEM 5 the presence of plasmid coded beta-lactamases in Esch. coli and H. influenzae did not affect the antibacterial activity of cefpodoxime proxetil [7].
  • Two other patients had multi-resistant klebsiellas, one of them an SHV-5 producer and one a TEM-5 producer, but these could be distinguished from each other and from the outbreak strain by serological and RAPD typing and by the genetics and mechanisms of their resistances [1].

Anatomical context of GPR124


Associations of GPR124 with chemical compounds


Other interactions of GPR124

  • GPR124 and GPR125 have a leucine rich repeat (LRR), an immunoglobulin (Ig) domain, and a hormone-binding domain (HBD) [8].

Analytical, diagnostic and therapeutic context of GPR124


  1. A hospital outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae investigated by RAPD typing and analysis of the genetics and mechanisms of resistance. Shannon, K., Fung, K., Stapleton, P., Anthony, R., Power, E., French, G. J. Hosp. Infect. (1998) [Pubmed]
  2. Proteolytically Processed Soluble Tumor Endothelial Marker (TEM) 5 Mediates Endothelial Cell Survival during Angiogenesis by Linking Integrin {alpha}vbeta3 to Glycosaminoglycans. Vallon, M., Essler, M. J. Biol. Chem. (2006) [Pubmed]
  3. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Yamamoto, Y., Irie, K., Asada, M., Mino, A., Mandai, K., Takai, Y. Oncogene (2004) [Pubmed]
  4. A method using TEM-5-beta-lactamase to assay imipenem. Sotto, A., Foulongne, V., Sirot, D., Jourdan, J. J. Antimicrob. Chemother. (1999) [Pubmed]
  5. In-vitro evaluation of beta-lactamase inhibition by latamoxef and imipenem. Sotto, A., Brunschwig, C., O'Callaghan, D., Ramuz, M., Jourdan, J. J. Antimicrob. Chemother. (1996) [Pubmed]
  6. Experimental endogenous septicaemia caused by Klebsiella pneumoniae and Escherichia coli in mice. Hirakata, Y., Furuya, N., Matsumoto, T., Tateda, K., Yamaguchi, K. J. Med. Microbiol. (1996) [Pubmed]
  7. Antibacterial activity of cefpodoxime proxetil in a pharmacokinetic in-vitro model. Wiedemann, B., Jansen, A. J. Antimicrob. Chemother. (1990) [Pubmed]
  8. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Fredriksson, R., Gloriam, D.E., Höglund, P.J., Lagerström, M.C., Schiöth, H.B. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  9. Properties of extended-spectrum beta-lactamases constructed by site-directed mutagenesis. Takenouchi, T., Ishii, Y., Yamaguchi, K. J. Infect. Chemother. (2002) [Pubmed]
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