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Smallwood, P.M. et al.

Fibroblast growth factor ( FGF) homologous factors: new members of the FGF family implicated in nervous system development.

Four new members of the fibroblast growth factor ( FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 (basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.[1]

References

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Smallwood, P.M., Munoz-Sanjuan, I., Tong, P., Macke, J.P., Hendry, S.H., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Nathans, J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]

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