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Gene Review

Fgf1  -  fibroblast growth factor 1

Mus musculus

Synonyms: Acidic fibroblast growth factor, Dffrx, FGF-1, Fam, Fgf-1, ...
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Disease relevance of Fgf1


Psychiatry related information on Fgf1


High impact information on Fgf1


Chemical compound and disease context of Fgf1


Biological context of Fgf1


Anatomical context of Fgf1


Associations of Fgf1 with chemical compounds


Physical interactions of Fgf1


Enzymatic interactions of Fgf1


Regulatory relationships of Fgf1


Other interactions of Fgf1


Analytical, diagnostic and therapeutic context of Fgf1

  • Using a combination of genetically engineered mice and an organ culture system, we identified novel roles for fibroblast growth factor (FGF) and Hedgehog (HH) signaling in coronary vascular development [38].
  • Northern blot analysis of messenger RNA (mRNA) from total BM and HEL cells showed a 4.4-kb mRNA specific for FGF receptors type 1 (flg) and type 2 (bek) [19].
  • Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy [46].
  • In Western blots, this antibody specifically interacted with a FGF 8b isoform that was identical between mouse and human but was not identical to other murine 8a and 8c isoforms [1].
  • In addition, analysis by confocal immunofluorescence microscopy of quiescent and FGF-1-stimulated NIH 3T3 cells reveal a prominent perinuclear FGFR-1 staining pattern in the cells exposed to FGF-1 but not in the quiescent population [28].


  1. High frequency of fibroblast growth factor (FGF) 8 expression in clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF 8. Tanaka, A., Furuya, A., Yamasaki, M., Hanai, N., Kuriki, K., Kamiakito, T., Kobayashi, Y., Yoshida, H., Koike, M., Fukayama, M. Cancer Res. (1998) [Pubmed]
  2. Suppression of autocrine cell proliferation and tumorigenesis of human melanoma cells and fibroblast growth factor transformed fibroblasts by a kinase-deficient FGF receptor 1: evidence for the involvement of Src-family kinases. Yayon, A., Ma, Y.S., Safran, M., Klagsbrun, M., Halaban, R. Oncogene (1997) [Pubmed]
  3. Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis. Cassina, P., Pehar, M., Vargas, M.R., Castellanos, R., Barbeito, A.G., Estévez, A.G., Thompson, J.A., Beckman, J.S., Barbeito, L. J. Neurochem. (2005) [Pubmed]
  4. Expression cDNA cloning of fibroblast growth factor (FGF) receptor in mouse breast cancer cells: a variant form in FGF-responsive transformed cells. Kouhara, H., Kasayama, S., Saito, H., Matsumoto, K., Sato, B. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  5. Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. Timmer, M., Cesnulevicius, K., Winkler, C., Kolb, J., Lipokatic-Takacs, E., Jungnickel, J., Grothe, C. J. Neurosci. (2007) [Pubmed]
  6. Psychometric analysis in children with mental retardation due to perinatal hypoxia treated with fibroblast growth factor (FGF) and showing improvement in mental development. Aguilar, L.C., Islas, A., Rosique, P., Hernandez, B., Portillo, E., Herrera, J.M., Cortes, R., Cruz, S., Alfaro, F., Martin, R. Journal of intellectual disability research : JIDR. (1993) [Pubmed]
  7. Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection. Hashimoto, M., Sagara, Y., Langford, D., Everall, I.P., Mallory, M., Everson, A., Digicaylioglu, M., Masliah, E. J. Biol. Chem. (2002) [Pubmed]
  8. The fibroblast growth factor system and mood disorders. Turner, C.A., Akil, H., Watson, S.J., Evans, S.J. Biol. Psychiatry (2006) [Pubmed]
  9. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Maness, P.F., Walsh, R.C. Cell (1982) [Pubmed]
  10. Functions of FGF signalling from the apical ectodermal ridge in limb development. Sun, X., Mariani, F.V., Martin, G.R. Nature (2002) [Pubmed]
  11. Attenuation of FGF signalling in mouse beta-cells leads to diabetes. Hart, A.W., Baeza, N., Apelqvist, A., Edlund, H. Nature (2000) [Pubmed]
  12. Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Heaney, A.P., Horwitz, G.A., Wang, Z., Singson, R., Melmed, S. Nat. Med. (1999) [Pubmed]
  13. Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. Mohammadi, M., Froum, S., Hamby, J.M., Schroeder, M.C., Panek, R.L., Lu, G.H., Eliseenkova, A.V., Green, D., Schlessinger, J., Hubbard, S.R. EMBO J. (1998) [Pubmed]
  14. Characterization of [125I]acidic fibroblast growth factor binding to the cloned human fibroblast growth factor receptor, FGF-flg, on NIH 3T3 cell membranes: inhibitory effects of heparin, pertussis toxin and guanine nucleotides. Jarvis, M.F., Gessner, G.W., Martin, G.E., Jaye, M., Ravera, M.W., Dionne, C.A. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  15. Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism. Palmen, M., Daemen, M.J., De Windt, L.J., Willems, J., Dassen, W.R., Heeneman, S., Zimmermann, R., Van Bilsen, M., Doevendans, P.A. J. Am. Coll. Cardiol. (2004) [Pubmed]
  16. Antiangiogenic activity of semisynthetic biotechnological heparins: low-molecular-weight-sulfated Escherichia coli K5 polysaccharide derivatives as fibroblast growth factor antagonists. Presta, M., Oreste, P., Zoppetti, G., Belleri, M., Tanghetti, E., Leali, D., Urbinati, C., Bugatti, A., Ronca, R., Nicoli, S., Moroni, E., Stabile, H., Camozzi, M., Hernandez, G.A., Mitola, S., Dell'Era, P., Rusnati, M., Ribatti, D. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  17. From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model. Drab, M., Haller, H., Bychkov, R., Erdmann, B., Lindschau, C., Haase, H., Morano, I., Luft, F.C., Wobus, A.M. FASEB J. (1997) [Pubmed]
  18. High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains. Cheon, H.G., LaRochelle, W.J., Bottaro, D.P., Burgess, W.H., Aaronson, S.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  19. Interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis and demonstration of FGF receptor expression in megakaryocytes and megakaryocytic-like cells. Bikfalvi, A., Han, Z.C., Fuhrmann, G. Blood (1992) [Pubmed]
  20. FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens. Chow, R.L., Roux, G.D., Roghani, M., Palmer, M.A., Rifkin, D.B., Moscatelli, D.A., Lang, R.A. Development (1995) [Pubmed]
  21. Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation. Haraguchi, R., Suzuki, K., Murakami, R., Sakai, M., Kamikawa, M., Kengaku, M., Sekine, K., Kawano, H., Kato, S., Ueno, N., Yamada, G. Development (2000) [Pubmed]
  22. Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Finch, P.W., Rubin, J.S. Adv. Cancer Res. (2004) [Pubmed]
  23. Differential activation of mitogen-activated protein kinase in response to basic fibroblast growth factor in skeletal muscle cells. Campbell, J.S., Wenderoth, M.P., Hauschka, S.D., Krebs, E.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  24. Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1. Levi, E., Fridman, R., Miao, H.Q., Ma, Y.S., Yayon, A., Vlodavsky, I. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  25. Direct activation of phospholipase C-gamma by fibroblast growth factor receptor is not required for mesoderm induction in Xenopus animal caps. Muslin, A.J., Peters, K.G., Williams, L.T. Mol. Cell. Biol. (1994) [Pubmed]
  26. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Xu, X., Weinstein, M., Li, C., Naski, M., Cohen, R.I., Ornitz, D.M., Leder, P., Deng, C. Development (1998) [Pubmed]
  27. Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3. Ornitz, D.M., Leder, P. J. Biol. Chem. (1992) [Pubmed]
  28. Intact and functional fibroblast growth factor (FGF) receptor-1 trafficks near the nucleus in response to FGF-1. Prudovsky, I., Savion, N., Zhan, X., Friesel, R., Xu, J., Hou, J., McKeehan, W.L., Maciag, T. J. Biol. Chem. (1994) [Pubmed]
  29. Androgen and fibroblast growth factor (FGF) regulation of FGF receptors in S115 mouse mammary tumor cells. Ruohola, J.K., Valve, E.M., Vainikka, S., Alitalo, K., Härkönen, P.L. Endocrinology (1995) [Pubmed]
  30. Suramin interrupts androgen-inducible autocrine loop involving heparin binding growth factor in mouse mammary cancer (Shionogi carcinoma 115) cells. Kasayama, S., Saito, H., Kouhara, H., Sumitani, S., Sato, B. J. Cell. Physiol. (1993) [Pubmed]
  31. A nuclear export sequence located on a beta-strand in fibroblast growth factor-1. Nilsen, T., Rosendal, K.R., Sørensen, V., Wesche, J., Olsnes, S., Wiedłocha, A. J. Biol. Chem. (2007) [Pubmed]
  32. Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. Bottaro, D.P., Rubin, J.S., Ron, D., Finch, P.W., Florio, C., Aaronson, S.A. J. Biol. Chem. (1990) [Pubmed]
  33. Generation of a specific immunological response to FGF-2 does not affect wound healing or reproduction. Plum, S.M., Vu, H.A., Mercer, B., Fogler, W.E., Fortier, A.H. Immunopharmacology and immunotoxicology. (2004) [Pubmed]
  34. FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. MacArthur, C.A., Lawshé, A., Xu, J., Santos-Ocampo, S., Heikinheimo, M., Chellaiah, A.T., Ornitz, D.M. Development (1995) [Pubmed]
  35. Fibroblast growth factor inhibits insulin-like growth factor-II (IGF-II) gene expression and increases IGF-I receptor abundance in BC3H-1 muscle cells. Rosenthal, S.M., Brown, E.J., Brunetti, A., Goldfine, I.D. Mol. Endocrinol. (1991) [Pubmed]
  36. Increased transduction of skeletal muscle cells by fibroblast growth factor-modified adenoviral vectors. Menezes, K.M., Mok, H.S., Barry, M.A. Hum. Gene Ther. (2006) [Pubmed]
  37. Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle. Zhan, X., Hu, X., Hampton, B., Burgess, W.H., Friesel, R., Maciag, T. J. Biol. Chem. (1993) [Pubmed]
  38. Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Lavine, K.J., White, A.C., Park, C., Smith, C.S., Choi, K., Long, F., Hui, C.C., Ornitz, D.M. Genes Dev. (2006) [Pubmed]
  39. Fibroblast growth factor (FGF) 3 from Xenopus laevis (XFGF3) binds with high affinity to FGF receptor 2. Mathieu, M., Kiefer, P., Mason, I., Dickson, C. J. Biol. Chem. (1995) [Pubmed]
  40. Interaction of androgen-induced autocrine heparin-binding growth factor with fibroblast growth factor receptor on androgen-dependent Shionogi carcinoma 115 cells. Nonomura, N., Lu, J., Tanaka, A., Yamanishi, H., Sato, B., Sonoda, T., Matsumoto, K. Cancer Res. (1990) [Pubmed]
  41. Basic fibroblast growth factor and fibroblast growth factor receptors in adult olfactory epithelium. Hsu, P., Yu, F., Féron, F., Pickles, J.O., Sneesby, K., Mackay-Sim, A. Brain Res. (2001) [Pubmed]
  42. Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts. Xiao, L., Naganawa, T., Obugunde, E., Gronowicz, G., Ornitz, D.M., Coffin, J.D., Hurley, M.M. J. Biol. Chem. (2004) [Pubmed]
  43. Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation. Govindarajan, V., Overbeek, P.A. Development (2001) [Pubmed]
  44. Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic mice. Robinson, M.L., Ohtaka-Maruyama, C., Chan, C.C., Jamieson, S., Dickson, C., Overbeek, P.A., Chepelinsky, A.B. Dev. Biol. (1998) [Pubmed]
  45. Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dichmann, D.S., Miller, C.P., Jensen, J., Scott Heller, R., Serup, P. Dev. Dyn. (2003) [Pubmed]
  46. Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Aggarwal, V.S., Liao, J., Bondarev, A., Schimmang, T., Lewandoski, M., Locker, J., Shanske, A., Campione, M., Morrow, B.E. Hum. Mol. Genet. (2006) [Pubmed]
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