Gene Review:
FGF1 - fibroblast growth factor 1 (acidic)
Homo sapiens
Synonyms:
AFGF, Acidic fibroblast growth factor, ECGF, ECGF-beta, ECGFA, ...
- The non-classical export routes: FGF1 and IL-1alpha point the way. Prudovsky, I., Mandinova, A., Soldi, R., Bagala, C., Graziani, I., Landriscina, M., Tarantini, F., Duarte, M., Bellum, S., Doherty, H., Maciag, T. J. Cell. Sci. (2003)
- Construction of a yeast artificial chromosome contig encompassing the human acidic fibroblast growth factor (FGF1) gene: toward the cloning of the ANLL/MDS tumor-suppressor gene. Chiu, I.M., Gilmore, E.C., Liu, Y., Payson, R.A. Genomics (1994)
- Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis. Huang, X., Yu, C., Jin, C., Yang, C., Xie, R., Cao, D., Wang, F., McKeehan, W.L. Mol. Carcinog. (2006)
- Fibroblast growth factor modulates HIV coreceptor CXCR4 expression by neural cells. HNRC Group. Sanders, V.J., Everall, I.P., Johnson, R.W., Masliah, E. J. Neurosci. Res. (2000)
- Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease. Yamagata, H., Chen, Y., Akatsu, H., Kamino, K., Ito, J., Yokoyama, S., Yamamoto, T., Kosaka, K., Miki, T., Kondo, I. Biochem. Biophys. Res. Commun. (2004)
- Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerbils. Li, A.J., Oomura, Y., Sasaki, K., Suzuki, K., Hori, T. Physiol. Behav. (1999)
- Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M. Cell (2000)
- Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Spivak-Kroizman, T., Lemmon, M.A., Dikic, I., Ladbury, J.E., Pinchasi, D., Huang, J., Jaye, M., Crumley, G., Schlessinger, J., Lax, I. Cell (1994)
- Dual mode of signal transduction by externally added acidic fibroblast growth factor. Wiedłocha, A., Falnes, P.O., Madshus, I.H., Sandvig, K., Olsnes, S. Cell (1994)
- Protection of rat myocardium by mitogenic and non-mitogenic fibroblast growth factor during post-ischemic reperfusion. Cuevas, P., Carceller, F., Lozano, R.M., Crespo, A., Zazo, M., Giménez-Gallego, G. Growth Factors (1997)
- Both autocrine and paracrine effects of transfected acidic fibroblast growth factor are involved in the estrogen-independent and antiestrogen-resistant growth of MCF-7 breast cancer cells. Zhang, L., Kharbanda, S., Hanfelt, J., Kern, F.G. Cancer Res. (1998)
- Acidic fibroblast growth factor (FGF-1) and FGF receptor 1 signaling in human Y79 retinoblastoma. Siffroi-Fernandez, S., Cinaroglu, A., Fuhrmann-Panfalone, V., Normand, G., Bugra, K., Sahel, J., Hicks, D. Arch. Ophthalmol. (2005)
- Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. La Rosa, S., Sessa, F., Colombo, L., Tibiletti, M.G., Furlan, D., Capella, C. J. Clin. Pathol. (2001)
- Fibroblast growth factor mediates hypoxia-induced endothelin-- a receptor expression in lung artery smooth muscle cells. Li, P., Oparil, S., Sun, J.Z., Thompson, J.A., Chen, Y.F. J. Appl. Physiol. (2003)
- The involvement of heparan sulfate (HS) in FGF1/HS/FGFR1 signaling complex. Wu, Z.L., Zhang, L., Yabe, T., Kuberan, B., Beeler, D.L., Love, A., Rosenberg, R.D. J. Biol. Chem. (2003)
- The small GTPases Ras, Rac, and Cdc42 transcriptionally regulate expression of human fibroblast growth factor 1. Chotani, M.A., Touhalisky, K., Chiu, I.M. J. Biol. Chem. (2000)
- The neurotrophic activity of fibroblast growth factor 1 (FGF1) depends on endogenous FGF1 expression and is independent of the mitogen-activated protein kinase cascade pathway. Renaud, F., Desset, S., Oliver, L., Gimenez-Gallego, G., Van Obberghen, E., Courtois, Y., Laurent, M. J. Biol. Chem. (1996)
- Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes. Robinson, C.J., Harmer, N.J., Goodger, S.J., Blundell, T.L., Gallagher, J.T. J. Biol. Chem. (2005)
- FGF2-Heparin co-crystal complex-assisted design of mutants FGF1 and FGF7 with predictable heparin affinities. Wong, P., Burgess, W.H. J. Biol. Chem. (1998)
- Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro. Landriscina, M., Prudovsky, I., Mouta Carreira, C., Soldi, R., Tarantini, F., Maciag, T. J. Biol. Chem. (2000)
- Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Pellegrini, L., Burke, D.F., von Delft, F., Mulloy, B., Blundell, T.L. Nature (2000)
- Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. Landriscina, M., Bagalá, C., Mandinova, A., Soldi, R., Micucci, I., Bellum, S., Prudovsky, I., Maciag, T. J. Biol. Chem. (2001)
- The effect of in vitro fibroblast growth factors on cell proliferation in pancreas from normal and streptozotocin-treated rats. Ogneva, V., Martinova, Y. Diabetes Res. Clin. Pract. (2002)
- Production and oestrogen regulation of FGF1 in normal and cancer breast cells. El Yazidi, I., Renaud, F., Laurent, M., Courtois, Y., Boilly-Marer, Y. Biochim. Biophys. Acta (1998)
- Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. Mori, S., Wu, C.Y., Yamaji, S., Saegusa, J., Shi, B., Ma, Z., Kuwabara, Y., Lam, K.S., Isseroff, R.R., Takada, Y.K., Takada, Y. J. Biol. Chem. (2008)
- S100A13, a new marker of angiogenesis in human astrocytic gliomas. Landriscina, M., Schinzari, G., Di Leonardo, G., Quirino, M., Cassano, A., D'Argento, E., Lauriola, L., Scerrati, M., Prudovsky, I., Barone, C. J. Neurooncol. (2006)
- Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG). Ruta, M., Burgess, W., Givol, D., Epstein, J., Neiger, N., Kaplow, J., Crumley, G., Dionne, C., Jaye, M., Schlessinger, J. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase. Kan, M., Wu, X., Wang, F., McKeehan, W.L. J. Biol. Chem. (1999)
- Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor. Kolpakova, E., Wiedłocha, A., Stenmark, H., Klingenberg, O., Falnes, P.O., Olsnes, S. Biochem. J. (1998)
- Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection. Zhao, X.M., Frist, W.H., Yeoh, T.K., Miller, G.G. J. Clin. Invest. (1994)
- Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors. Haugsten, E.M., Sørensen, V., Brech, A., Olsnes, S., Wesche, J. J. Cell. Sci. (2005)
- Fibroblast growth factor-1 transcriptionally induces membrane type-1 matrix metalloproteinase expression in prostate carcinoma cell line. Udayakumar, T.S., Nagle, R.B., Bowden, G.T. Prostate (2004)
- The fibroblast growth factor receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF. Lin, H.Y., Xu, J., Ornitz, D.M., Halegoua, S., Hayman, M.J. J. Neurosci. (1996)
- A functional fibroblast growth factor-1 immunoglobulin fusion protein. Dikov, M.M., Reich, M.B., Dworkin, L., Thomas, J.W., Miller, G.G. J. Biol. Chem. (1998)
- Structural interactions of fibroblast growth factor receptor with its ligands. Stauber, D.J., DiGabriele, A.D., Hendrickson, W.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines. Tomlinson, D.C., L'Hôte, C.G., Kennedy, W., Pitt, E., Knowles, M.A. Cancer Res. (2005)
- Induction of growth factor RNA expression in human malignant melanoma: markers of transformation. Albino, A.P., Davis, B.M., Nanus, D.M. Cancer Res. (1991)
- Biosynthetic oligosaccharide libraries for identification of protein-binding heparan sulfate motifs. Exploring the structural diversity by screening for fibroblast growth factor (FGF)1 and FGF2 binding. Jemth, P., Kreuger, J., Kusche-Gullberg, M., Sturiale, L., Giménez-Gallego, G., Lindahl, U. J. Biol. Chem. (2002)
- The location of acidic fibroblast growth factor in the breast is dependent on the activity of proteases present in breast cancer tissue. Coope, R.C., Browne, P.J., Yiangou, C., Bansal, G.S., Walters, J., Groome, N., Shousha, S., Johnston, C.L., Coombes, R.C., Gomm, J.J. Br. J. Cancer (1997)