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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Combined chemokine and cytokine gene transfer enhances antitumor immunity.

The probability of producing a specific antitumor response should be increased by multiplying the number of T lymphocytes that encounter the malignant cells. We tested this prediction in a murine model, using a recently discovered T-cell chemokine, lymphotactin (Lptn). This chemokine increased tumor cell infiltration with CD4+ lymphocytes but generated little antitumor activity. Coexpression of the T-cell growth factor interleukin-2, however, greatly expanded the T lymphocytes attracted by Lptn, affording protection from the growth of established tumor in a CD4+ and CD8+ T cell-dependent manner. Lesser synergy was seen with GM-CSF. Hence coexpression of a T-cell chemokine and T-cell growth factor potentiates antitumor responses in vivo, suggesting a general strategy to improve cancer immunotherapy.[1]


  1. Combined chemokine and cytokine gene transfer enhances antitumor immunity. Dilloo, D., Bacon, K., Holden, W., Zhong, W., Burdach, S., Zlotnik, A., Brenner, M. Nat. Med. (1996) [Pubmed]
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