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Cxcl5  -  chemokine (C-X-C motif) ligand 5

Mus musculus

Synonyms: AMCF-II, C-X-C motif chemokine 5, Cytokine LIX, ENA-78, GCP-2, ...
 
 
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Disease relevance of Cxcl5

  • Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis [1].
  • Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation [2].
  • Moreover, the data suggest that individual chemokine genes are differentially regulated in response to LPS, suggesting unique roles during the sepsis cascade [3].
  • Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus [4].
  • The Chemokine Receptor CXCR3 Attenuates the Control of Chronic Mycobacterium tuberculosis Infection in BALB/c Mice [5].
 

Psychiatry related information on Cxcl5

  • Serum cytokine and chemokine levels were examined in mice following 36 h of sleep deprivation, or after exposure to a known physical stressor (rotational stress) [6].
  • Our findings suggest that HIV-1 infection with concurrent drug abuse might profoundly increase chemokine levels in the striatum resulting in enhanced damage to the dopaminergic system [7].
 

High impact information on Cxcl5

 

Chemical compound and disease context of Cxcl5

 

Biological context of Cxcl5

 

Anatomical context of Cxcl5

  • We propose that chemokine expression links T-cell antigen recognition and activation to subsequent CNS inflammatory pathology in chronic relapsing EAE [20].
  • To our knowledge, these data are also the first demonstration that the C-C chemokine JE is involved in neutrophil recruitment in a physiologic system in vivo [21].
  • This cascade of chemokine interactions may contribute to renal infiltration and leukocyte activation [22].
  • These findings indicate that selective regulation of chemokine expression in vivo may result from differential response of macrophages to pro- and antiinflammatory stimuli and to cell type-specific patterns of stimulus sensitivity [3].
  • Previous in vitro studies demonstrated that both Plasmodium falciparum HZ and synthetic HZ (sHZ), beta-hematin, induce macrophage/monocyte chemokine and proinflammatory cytokine secretion [18].
 

Associations of Cxcl5 with chemical compounds

 

Physical interactions of Cxcl5

  • Fc gamma RIII-mediated production of TNF-alpha induces immune complex alveolitis independently of CXC chemokine generation [27].
  • The inhibitory effect of CXCL10/IP-10 on the binding of dengue virus to cells may represent a novel contribution of this chemokine to the host defense against viral infection [28].
  • Macrophage inflammatory protein-3alpha/CCL20 is a recently identified chemokine that binds to CCR6 and acts as a chemoattractant for memory/differentiated T-cells, B-cells, and immature dendritic cells [29].
  • This indicated a G protein-mediated binding and pointed at a contribution of chemokine receptors to B-cell adhesion [30].
  • The VIP/PACAP inhibition of both chemokine production and of NFkB binding is mediated through the specific receptor VPAC1 and involves a cAMP-dependent intracellular pathway [31].
 

Enzymatic interactions of Cxcl5

 

Co-localisations of Cxcl5

 

Regulatory relationships of Cxcl5

 

Other interactions of Cxcl5

  • Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha [21].
  • RANTES-mediated chemokine amplification in DC may prolong inflammatory responses and shape the microenvironment, potentially enhancing acquired and innate immune responses [34].
  • The chemokine receptor CXCR3 plays a significant role in regulating the migration of Th1 cells [5].
  • We investigated the fibrotic potential of MCP-1 in the gut by overexpressing this chemokine in the mouse colorectal wall [37].
  • Tristetraprolin and LPS-inducible CXC chemokine are rapidly induced in presumptive satellite cells in response to skeletal muscle injury [38].
 

Analytical, diagnostic and therapeutic context of Cxcl5

References

  1. Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis. Morrison, B.E., Park, S.J., Mooney, J.M., Mehrad, B. J. Clin. Invest. (2003) [Pubmed]
  2. Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation. Qiu, B., Frait, K.A., Reich, F., Komuniecki, E., Chensue, S.W. Am. J. Pathol. (2001) [Pubmed]
  3. Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo. Kopydlowski, K.M., Salkowski, C.A., Cody, M.J., van Rooijen, N., Major, J., Hamilton, T.A., Vogel, S.N. J. Immunol. (1999) [Pubmed]
  4. Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus. Aravalli, R.N., Hu, S., Rowen, T.N., Palmquist, J.M., Lokensgard, J.R. J. Immunol. (2005) [Pubmed]
  5. The Chemokine Receptor CXCR3 Attenuates the Control of Chronic Mycobacterium tuberculosis Infection in BALB/c Mice. Chakravarty, S.D., Xu, J., Lu, B., Gerard, C., Flynn, J., Chan, J. J. Immunol. (2007) [Pubmed]
  6. Sleep-deprived mice show altered cytokine production manifest by perturbations in serum IL-1ra, TNFa, and IL-6 levels. Hu, J., Chen, Z., Gorczynski, C.P., Gorczynski, L.Y., Kai, Y., Lee, L., Manuel, J., Gorczynski, R.M. Brain Behav. Immun. (2003) [Pubmed]
  7. Involvement of cytokines in human immunodeficiency virus-1 protein Tat and methamphetamine interactions in the striatum. Theodore, S., Cass, W.A., Maragos, W.F. Exp. Neurol. (2006) [Pubmed]
  8. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Katayama, Y., Battista, M., Kao, W.M., Hidalgo, A., Peired, A.J., Thomas, S.A., Frenette, P.S. Cell (2006) [Pubmed]
  9. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Li, Q., Park, P.W., Wilson, C.L., Parks, W.C. Cell (2002) [Pubmed]
  10. The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. Tsai, H.H., Frost, E., To, V., Robinson, S., Ffrench-Constant, C., Geertman, R., Ransohoff, R.M., Miller, R.H. Cell (2002) [Pubmed]
  11. Transcytosis and surface presentation of IL-8 by venular endothelial cells. Middleton, J., Neil, S., Wintle, J., Clark-Lewis, I., Moore, H., Lam, C., Auer, M., Hub, E., Rot, A. Cell (1997) [Pubmed]
  12. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Förster, R., Mattis, A.E., Kremmer, E., Wolf, E., Brem, G., Lipp, M. Cell (1996) [Pubmed]
  13. Kinetic profiles of sequential gene expressions for chemokines in mice with contact hypersensitivity. Mitsui, G., Mitsui, K., Hirano, T., Ohara, O., Kato, M., Niwano, Y. Immunol. Lett. (2003) [Pubmed]
  14. Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin. Penido, C., Vieira-de-Abreu, A., Bozza, M.T., Castro-Faria-Neto, H.C., Bozza, P.T. J. Immunol. (2003) [Pubmed]
  15. Role of chemokines and formyl peptides in pneumococcal pneumonia-induced monocyte/macrophage recruitment. Fillion, I., Ouellet, N., Simard, M., Bergeron, Y., Sato, S., Bergeron, M.G. J. Immunol. (2001) [Pubmed]
  16. C-C chemokine receptor 2 (CCR2) deficiency improves bleomycin-induced pulmonary fibrosis by attenuation of both macrophage infiltration and production of macrophage-derived matrix metalloproteinases. Okuma, T., Terasaki, Y., Kaikita, K., Kobayashi, H., Kuziel, W.A., Kawasuji, M., Takeya, M. J. Pathol. (2004) [Pubmed]
  17. Chemokine gene expression in bone marrow stromal cells: downregulation with sodium salicylate. Gautam, S.C., Pindolia, K.R., Noth, C.J., Janakiraman, N., Xu, Y.X., Chapman, R.A. Blood (1995) [Pubmed]
  18. Hemozoin-inducible proinflammatory events in vivo: potential role in malaria infection. Jaramillo, M., Plante, I., Ouellet, N., Vandal, K., Tessier, P.A., Olivier, M. J. Immunol. (2004) [Pubmed]
  19. Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. Chandrasekar, B., Melby, P.C., Sarau, H.M., Raveendran, M., Perla, R.P., Marelli-Berg, F.M., Dulin, N.O., Singh, I.S. J. Biol. Chem. (2003) [Pubmed]
  20. Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis. Glabinski, A.R., Tani, M., Strieter, R.M., Tuohy, V.K., Ransohoff, R.M. Am. J. Pathol. (1997) [Pubmed]
  21. Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha. Tessier, P.A., Naccache, P.H., Clark-Lewis, I., Gladue, R.P., Neote, K.S., McColl, S.R. J. Immunol. (1997) [Pubmed]
  22. Chemokine amplification in mesangial cells. Luo, Y., Lloyd, C., Gutierrez-Ramos, J.C., Dorf, M.E. J. Immunol. (1999) [Pubmed]
  23. Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2. Wuyts, A., Haelens, A., Proost, P., Lenaerts, J.P., Conings, R., Opdenakker, G., Van Damme, J. J. Immunol. (1996) [Pubmed]
  24. Impact of cethromycin (ABT-773) therapy on microbiological, histologic, immunologic, and respiratory indices in a murine model of Mycoplasma pneumoniae lower respiratory infection. Ríos, A.M., Mejías, A., Chávez-Bueno, S., Fonseca-Aten, M., Katz, K., Hatfield, J., Gómez, A.M., Jafri, H.S., McCracken, G.H., Ramilo, O., Hardy, R.D. Antimicrob. Agents Chemother. (2004) [Pubmed]
  25. Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration. Salkowski, C.A., Detore, G., Franks, A., Falk, M.C., Vogel, S.N. Infect. Immun. (1998) [Pubmed]
  26. Curcumin, a compound with anti-inflammatory and anti-oxidant properties, down-regulates chemokine expression in bone marrow stromal cells. Xu, Y.X., Pindolia, K.R., Janakiraman, N., Noth, C.J., Chapman, R.A., Gautam, S.C. Exp. Hematol. (1997) [Pubmed]
  27. Fc gamma RIII-mediated production of TNF-alpha induces immune complex alveolitis independently of CXC chemokine generation. Chouchakova, N., Skokowa, J., Baumann, U., Tschernig, T., Philippens, K.M., Nieswandt, B., Schmidt, R.E., Gessner, J.E. J. Immunol. (2001) [Pubmed]
  28. Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate. Chen, J.P., Lu, H.L., Lai, S.L., Campanella, G.S., Sung, J.M., Lu, M.Y., Wu-Hsieh, B.A., Lin, Y.L., Lane, T.E., Luster, A.D., Liao, F. J. Immunol. (2006) [Pubmed]
  29. Astrocytes are the major intracerebral source of macrophage inflammatory protein-3alpha/CCL20 in relapsing experimental autoimmune encephalomyelitis and in vitro. Ambrosini, E., Columba-Cabezas, S., Serafini, B., Muscella, A., Aloisi, F. Glia (2003) [Pubmed]
  30. CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress. Meissner, A., Zilles, O., Varona, R., Jozefowski, K., Ritter, U., Marquez, G., Hallmann, R., Korner, H. Blood (2003) [Pubmed]
  31. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit chemokine production in activated microglia. Delgado, M., Jonakait, G.M., Ganea, D. Glia (2002) [Pubmed]
  32. A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16. Gough, P.J., Garton, K.J., Wille, P.T., Rychlewski, M., Dempsey, P.J., Raines, E.W. J. Immunol. (2004) [Pubmed]
  33. CD8+ T cells produce RANTES during acute rejection of murine allogeneic skin grafts. Koga, S., Novick, A.C., Toma, H., Fairchild, R.L. Transplantation (1999) [Pubmed]
  34. RANTES-induced chemokine cascade in dendritic cells. Fischer, F.R., Luo, Y., Luo, M., Santambrogio, L., Dorf, M.E. J. Immunol. (2001) [Pubmed]
  35. Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. Tran, P.B., Banisadr, G., Ren, D., Chenn, A., Miller, R.J. J. Comp. Neurol. (2007) [Pubmed]
  36. Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages. Kim, H.Y., Kim, H.S. Immunol. Cell Biol. (2007) [Pubmed]
  37. Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1. Motomura, Y., Khan, W.I., El-Sharkawy, R.T., Verma-Gandhu, M., Verdu, E.F., Gauldie, J., Collins, S.M. Gut (2006) [Pubmed]
  38. Tristetraprolin and LPS-inducible CXC chemokine are rapidly induced in presumptive satellite cells in response to skeletal muscle injury. Sachidanandan, C., Sambasivan, R., Dhawan, J. J. Cell. Sci. (2002) [Pubmed]
  39. Early and late chemokine production correlates with cellular recruitment in cardiac allograft vasculopathy. Yun, J.J., Fischbein, M.P., Laks, H., Fishbein, M.C., Espejo, M.L., Ebrahimi, K., Irie, Y., Berliner, J., Ardehali, A. Transplantation (2000) [Pubmed]
 
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