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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ischemic colitis during interferon-alpha treatment for chronic active hepatitis C.

Between 1991 and 1994, at Hoshigaoka Koseinenkin Hospital, we treated 280 patients with chronic hepatitis C with interferon ( IFN), and ischemic colitis occurred in two patients (0.7%) during the treatment. Melena appeared in case 1 in the 2nd month after the initiation of IFN-alpha treatment, and in case 2 in the 6th month. In both patients, longitudinal ulcerations in the descending colon were revealed by urgent colonoscopy, and these resolved within 2 weeks after discontinuation of the IFN treatment. It appears that ischemic colitis was associated with the IFN treatment, suggesting that attention should be paid to this possible complication.[1]


  1. Ischemic colitis during interferon-alpha treatment for chronic active hepatitis C. Tada, H., Saitoh, S., Nakagawa, Y., Hirana, H., Morimoto, M., Shima, T., Shimamoto, K., Okanoue, T., Kashima, K. J. Gastroenterol. (1996) [Pubmed]
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