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MeSH Review

Colon, Descending

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Disease relevance of Colon, Descending


High impact information on Colon, Descending


Chemical compound and disease context of Colon, Descending


Biological context of Colon, Descending


Anatomical context of Colon, Descending


Associations of Colon, Descending with chemical compounds

  • Animals received the first of five weekly injections of azoxymethane (total dose 50 mg/kg) either immediately after transection of the descending colon or at 2, 4, 8, and 12 weeks later; controls received handling of the bowel alone [22].
  • Consequently ratios of butyrate/glutamine metabolism were higher in the descending colon (20.6 (14.3)) than in the ascending colon (14.3 (9.6)) (p < 0.05) [23].
  • The mucosal addition of 0.1 mM amiloride to descending colon totally abolished the transepithelial voltage (Vt) and short-circuit current (Isc), and significantly increased the total tissue resistance (Rt) by 19% (p less than 0.005) [24].
  • In each volunteer, the solution was released into five different regions of the gastrointestinal tract: the stomach (B), jejunum (C1), ileum (C2), ascending colon (D1), and descending colon (D2) [25].
  • The extracellular concentration of calcium and sodium and the contraction of rat descending colon in response to angiotensin [proceedings] [26].

Gene context of Colon, Descending

  • CONCLUSION: IBS patients demonstrate lower levels of PYY in the descending colon than controls [27].
  • In the EDNRB locus, two mutations were observed; a nonsense mutation of Trp to stop at codon 275, and a T insertion at nucleotide 878, in patients with aganglionosis confined to the rectosigmoid colon, and the descending colon, respectively [28].
  • In contrast, protein concentration of CYP2E1 was significantly lower by ~81% in the sigmoid colon in comparison to the descending colon [29].
  • RESULTS: Human HJV mRNA expression was detected in the liver, heart, esophagus, pancreas, descending colon, ileocecum and skeletal muscle [30].
  • RESULTS: The median concentrations of bFGF in perfusates from the descending colon and rectum were increased 4-fold in CC patients compared with control patients [31].

Analytical, diagnostic and therapeutic context of Colon, Descending


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  3. Leiomyomatosis-like lymphangioleiomyomatosis of the colon in a female with tuberous sclerosis. Goh, S.G., Ho, J.M., Chuah, K.L., Tan, P.H., Poh, W.T., Riddell, R.H. Mod. Pathol. (2001) [Pubmed]
  4. Application of technetium-99m-labeled human serum albumin scan to assist surgical treatment of protein-losing enteropathy in Cronkhite-Canada syndrome: report of a case. Tseng, K.C., Sheu, B.S., Lee, J.C., Tsai, H.M., Chiu, N.T., Dai, Y.C. Dis. Colon Rectum (2005) [Pubmed]
  5. Selective inhibition of neuropeptide Y Y1 receptors by BIBP3226 in rat and human epithelial preparations. Tough, I.R., Cox, H.M. Eur. J. Pharmacol. (1996) [Pubmed]
  6. Colon epithelium. III. In vitro studies of colon carcinogenesis in Fischer 344 rats. N-methyl-N'-nitro-N-nitrosoguanidine-induced changes in colon epithelium in explant culture. Shamsuddin, A.K., Trump, B.F. J. Natl. Cancer Inst. (1981) [Pubmed]
  7. Role of prostaglandins and calcium in the effects of Entamoeba histolytica on colonic electrolyte transport. McGowan, K., Piver, G., Stoff, J.S., Donowitz, M. Gastroenterology (1990) [Pubmed]
  8. Serial observations of colonic carcinogenesis in the rat. Premalignant mucosa binds Ulex europeus agglutinin. Shioda, Y., Brown, W.R., Ahnen, D.J. Gastroenterology (1987) [Pubmed]
  9. Tissue-specific induction of p53 targets in vivo. Fei, P., Bernhard, E.J., El-Deiry, W.S. Cancer Res. (2002) [Pubmed]
  10. Lesions in the skin, intestine, and central nervous system induced by an antimetabolite of niacin. Aikawa, H., Suzuki, K. Am. J. Pathol. (1986) [Pubmed]
  11. Distribution of mesalamine enemas in patients with active distal ulcerative colitis. Chapman, N.J., Brown, M.L., Phillips, S.F., Tremaine, W.J., Schroeder, K.W., Dewanjee, M.K., Zinsmeister, A.R. Mayo Clin. Proc. (1992) [Pubmed]
  12. Cisapride stimulates contraction of idiopathic megacolonic smooth muscle in cats. Hasler, A.H., Washabau, R.J. J. Vet. Intern. Med. (1997) [Pubmed]
  13. On the pathogenesis of intestinal aganglionosis. A consideration based on electron microscopic observations of experimental and clinical aganglionoses. Furuta, T., Sakata, K., Kunieda, T., Kishimoto, Y. Experientia (1980) [Pubmed]
  14. Melatonin and colon carcinogenesis. III. Effect of melatonin on proliferative activity and apoptosis in colon mucosa and colon tumors induced by 1,2-dimethylhydrazine in rats. Anisimov, V.N., Popovich, I.G., Shtylik, A.V., Zabezhinski, M.A., Ben-Huh, H., Gurevich, P., Berman, V., Tendler, Y., Zusman, I. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (2000) [Pubmed]
  15. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Roediger, W.E. Gut (1980) [Pubmed]
  16. The effects of capsaicin upon electrogenic ion transport in rat descending colon. Yarrow, S., Ferrar, J.A., Cox, H.M. Naunyn Schmiedebergs Arch. Pharmacol. (1991) [Pubmed]
  17. Cell proliferation in the descending colon of dimethylhydrazine treated rats and in dimethylhydrazine induced adenocarcinomata. Tutton, P.J., Barkla, D.H. Virchows Archiv. B: Cell pathology. (1976) [Pubmed]
  18. Docosahexaenoic acid and signaling pathways in rabbit colon. Calderaro, V., Parrillo, C., Balestrieri, M.L., Giovane, A., Filippelli, A., Rossi, F. Mol. Pharmacol. (1994) [Pubmed]
  19. Apical membrane potassium and chloride permeabilities in surface cells of rabbit descending colon epithelium. Wills, N.K. J. Physiol. (Lond.) (1985) [Pubmed]
  20. Exon-intron organization, expression, and chromosomal localization of the human motilin gene. Yano, H., Seino, Y., Fujita, J., Yamada, Y., Inagaki, N., Takeda, J., Bell, G.I., Eddy, R.L., Fan, Y.S., Byers, M.G. FEBS Lett. (1989) [Pubmed]
  21. The effect of oral cisapride on colonic transit. Krevsky, B., Malmud, L.S., Maurer, A.H., Somers, M.B., Siegel, J.A., Fisher, R.S. Aliment. Pharmacol. Ther. (1987) [Pubmed]
  22. Proliferative instability and experimental carcinogenesis at colonic anastomoses. Roe, R., Fermor, B., Williamson, R.C. Gut (1987) [Pubmed]
  23. Ileal and colonic epithelial metabolism in quiescent ulcerative colitis: increased glutamine metabolism in distal colon but no defect in butyrate metabolism. Finnie, I.A., Taylor, B.A., Rhodes, J.M. Gut (1993) [Pubmed]
  24. Electrophysiology of the human colon: evidence of segmental heterogeneity. Sandle, G.I., Wills, N.K., Alles, W., Binder, H.J. Gut (1986) [Pubmed]
  25. Absorption differences of ciprofloxacin along the human gastrointestinal tract determined using a remote-control drug delivery device (HF-capsule). Staib, A.H., Beermann, D., Harder, S., Fuhr, U., Liermann, D. Am. J. Med. (1989) [Pubmed]
  26. The extracellular concentration of calcium and sodium and the contraction of rat descending colon in response to angiotensin [proceedings]. Crocker, A.D., Mayeka, I.M., Wilson, K.A. J. Physiol. (Lond.) (1978) [Pubmed]
  27. Abnormal levels of neuropeptide Y and peptide YY in the colon in irritable bowel syndrome. Simrén, M., Stotzer, P.O., Sjövall, H., Abrahamsson, H., Björnsson, E.S. European journal of gastroenterology & hepatology. (2003) [Pubmed]
  28. Mutation analysis of the RET, the endothelin-B receptor, and the endothelin-3 genes in sporadic cases of Hirschsprung's disease. Kusafuka, T., Wang, Y., Puri, P. J. Pediatr. Surg. (1997) [Pubmed]
  29. Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa. Bergheim, I., Bode, C., Parlesak, A. BMC clinical pharmacology [electronic resource]. (2005) [Pubmed]
  30. Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin. Rodriguez Martinez, A., Niemelä, O., Parkkila, S. Haematologica (2004) [Pubmed]
  31. Mucosal secretion and expression of basic fibroblast growth factor in patients with collagenous colitis. Taha, Y., Raab, Y., Larsson, A., Carlson, M., Lööf, L., Gerdin, B., Thörn, M. Am. J. Gastroenterol. (2003) [Pubmed]
  32. Thalidomide impairment of trinitrobenzene sulphonic acid-induced colitis in the rat - role of endothelial cell-leukocyte interaction. Lienenlüke, B., Stojanovic, T., Fiebig, T., Fayyazi, A., Germann, T., Hecker, M. Br. J. Pharmacol. (2001) [Pubmed]
  33. Active and passive properties of rabbit descending colon: a microelectrode and nystatin study. Wills, N.K., Lewis, S.A., Eaton, D.C. J. Membr. Biol. (1979) [Pubmed]
  34. Morphine effects on human colonic myoelectric activity in the postoperative period. Frantzides, C.T., Cowles, V., Salaymeh, B., Tekin, E., Condon, R.E. Am. J. Surg. (1992) [Pubmed]
  35. Small colonic J-pouch improves colonic retention of liquids--randomized, controlled trial with scintigraphy. Ho, Y.H., Yu, S., Ang, E.S., Seow-Choen, F., Sundram, F. Dis. Colon Rectum (2002) [Pubmed]
  36. Cyclic adenosine 3', 5' monophosphate: a possible indicator of premalignant changes in the large bowel. Latner, A.L., Turner, G.A., Tregoning, D. Ann. Clin. Biochem. (1979) [Pubmed]
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