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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Melena


High impact information on Melena

  • We studied the effects of tranexamic acid (an antifibrinolytic agent) and cimetidine on acute upper-gastrointestinal-tract bleeding in a double-blind randomized placebo-controlled trial in 775 patients with hematemesis or melena or both [6].
  • Although fever and rash subsided with administration of prednisolone, massive hematemesis appeared with melena [7].
  • A 47-yr-old woman presenting with high fever, rash, and melena was diagnosed with SLE from positive antinuclear antibodies, anti-dsDNA, and low complement titers [7].
  • With the presence of melena (RR = 101.63, p = 0.007), nonspecific gastrointestinal symptoms (RR = 12.54, p = 0.026), increasing age (RR = 1.09, p = 0.028) and abnormal CEA (RR = 240.79, p = 0.000), the risk of having cancer increased significantly and independently [8].
  • Immunosuppressive therapy (cyclophosphamide 500 mg and 1 mg of vincristine) markedly restored the platelet counts to 7.2 x 10(4)/microliter and ceased the melena; furthermore, the size of adrenal tumors decreased by more than 60% after therapy [9].

Chemical compound and disease context of Melena


Associations of Melena with chemical compounds

  • Effectiveness of high-dose intravenous immunoglobulin in a case of acquired von Willebrand syndrome with chronic melena not responsive to desmopressin and factor VIII concentrate [13].
  • The diagnosis was made preoperatively by pertechnetate technetium 99m isotope scanning and a barium meal examination, and we discuss the use of these investigations in children presenting with melena [14].
  • Intra-arterial prednisolone injection therapy was given, following which the melena gradually subsided and completely stopped within a few days [15].

Gene context of Melena


  1. Treatment with histamine H2 antagonists in acute upper gastrointestinal hemorrhage. Implications of randomized trials. Collins, R., Langman, M. N. Engl. J. Med. (1985) [Pubmed]
  2. Immune complexes containing factor V in a patient with an acquired neutralizing antibody. Chiu, H.C., Rao, A.K., Beckett, C., Colman, R.W. Blood (1985) [Pubmed]
  3. Predictive factors of positive findings in patients explored by push enteroscopy for unexplained GI bleeding. Lepère, C., Cuillerier, E., Van Gossum, A., Bezet, A., Schmit, A., Landi, B., Cellier, C. Gastrointest. Endosc. (2005) [Pubmed]
  4. Ibuprofen toxicosis in a dog. Spyridakis, L.K., Bacia, J.J., Barsanti, J.A., Brown, S.A. J. Am. Vet. Med. Assoc. (1986) [Pubmed]
  5. Treatment of gastric hemorrhage by pulverized omeprazole and antacid--concomitant administration via a nasogastric tube. Yamaguchi, T., Mukai, S., Kinoshita, E., Ohtani, H., Sawada, Y. International journal of clinical pharmacology and therapeutics. (2004) [Pubmed]
  6. Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding. Barer, D., Ogilvie, A., Henry, D., Dronfield, M., Coggon, D., French, S., Ellis, S., Atkinson, M., Langman, M. N. Engl. J. Med. (1983) [Pubmed]
  7. Massive gastrointestinal hemorrhage in systemic lupus erythematosus: successful treatment with corticosteroid pulse therapy. Hiraishi, H., Konishi, T., Ota, S., Shimada, T., Terano, A., Sugimoto, T. Am. J. Gastroenterol. (1999) [Pubmed]
  8. The value of CEA and CA 19-9 in detecting cancer in a group of high-risk subjects with gastrointestinal symptoms. Coban, E., Samur, M., Bozcuk, H., Ozdogan, M. Int. J. Biol. Markers (2003) [Pubmed]
  9. A case of malignant lymphoma producing autoantibody against platelet glycoprotein Ib. Nobuoka, A., Sakamaki, S., Kogawa, K., Fujikawa, K., Takahashi, M., Hirayama, Y., Takayanagi, N., Ikeda, H., Sekiguchi, S., Niitsu, Y. Int. J. Hematol. (1999) [Pubmed]
  10. Acute mercury poisoning by intentional ingestion of mercuric chloride. Yoshida, M., Satoh, H., Igarashi, M., Akashi, K., Yamamura, Y., Yoshida, K. Tohoku J. Exp. Med. (1997) [Pubmed]
  11. Peptic ulcer and duodenal stenosis: role of Helicobacter pylori infection. Annibale, B., Marignani, M., Luzzi, I., Delle Fave, G.F. The Italian journal of gastroenterology. (1995) [Pubmed]
  12. A comparative, double-blind study on tolfenamic acid in the treatment of rheumatoid arthritis. Rejholec, V., Vapaatalo, H., Tokola, O., Gothoni, G. Scand. J. Rheumatol. Suppl. (1979) [Pubmed]
  13. Effectiveness of high-dose intravenous immunoglobulin in a case of acquired von Willebrand syndrome with chronic melena not responsive to desmopressin and factor VIII concentrate. Castaman, G., Tosetto, A., Rodeghiero, F. Am. J. Hematol. (1992) [Pubmed]
  14. Perforation of the jejunum secondary to a duplication cyst lined with ectopic gastric mucosa. Royle, S.G., Doig, C.M. J. Pediatr. Surg. (1988) [Pubmed]
  15. Massive hemorrhage in a patient with intestinal Behçet's disease: report of a case. Fujita, H., Kiriyama, M., Kawamura, T., Ii, T., Takegawa, S., Dohba, S., Kojima, Y., Adachi, H., Morimoto, H., Kobayashi, A., Watanabe, K. Surgery today. (2002) [Pubmed]
  16. Ischemic colitis during interferon-alpha treatment for chronic active hepatitis C. Tada, H., Saitoh, S., Nakagawa, Y., Hirana, H., Morimoto, M., Shima, T., Shimamoto, K., Okanoue, T., Kashima, K. J. Gastroenterol. (1996) [Pubmed]
  17. Hemobilia: four case reports and review of the literature. Thong-Ngam, D., Shusang, V., Wongkusoltham, P., Brown, L., Kullavanijaya, P. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (2001) [Pubmed]
  18. Malaria in Kampuchea: clinical course of falciparum malaria in Chemin de Fer Hospital, Phnom Penh. Bouth, D.M., Giboda, M. Folia Parasitol. (1987) [Pubmed]
  19. Hepatocellular carcinoma with gastrointestinal hemorrhage caused by direct tumor invasion to the duodenum. Okusaka, T., Okada, S., Ishii, H., Nagahama, H., Yoshimori, M., Yamasaki, S., Takayasu, K., Kakizoe, T., Ochiai, A., Shimoda, T. Jpn. J. Clin. Oncol. (1997) [Pubmed]
  20. Rheumatoid arthritis associated with renal amyloidosis and crescentic glomerulonephritis. Murakami, H., Ura, N., Nagao, K., Tsuchihashi, K., Nakata, T., Agata, J., Satoh, M., Shimamoto, K. Intern. Med. (1998) [Pubmed]
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