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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A controlled trial of idebenone in Huntington's disease.

One hundred patients with clinically diagnosed Huntington's disease ( HD) were randomized to either idebenone, an antioxidant and enhancer of oxidative metabolism, or placebo, in a 1-year, double-blind, parallel-group study aimed at slowing the rate of progression of the disease. Ninety-one patients completed the study. There were no significant differences between groups on the primary outcome measures of the Huntington's Disease Activities of Daily Living Scale (ADL-an index of functional status) and the Quantified Neurologic Examination (QNE). Sample size calculations based on progression of the ADL and QNE in this study group revealed that a larger study group is necessary to detect any differences less than an almost complete halting of the disease. This argues for multicenter efforts for future therapeutic trials in HD.[1]

References

  1. A controlled trial of idebenone in Huntington's disease. Ranen, N.G., Peyser, C.E., Coyle, J.T., Bylsma, F.W., Sherr, M., Day, L., Folstein, M.F., Brandt, J., Ross, C.A., Folstein, S.E. Mov. Disord. (1996) [Pubmed]
 
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