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Chemical Compound Review

Idebenona     2-(10-hydroxydecyl)-5,6- dimethoxy-3-methyl...

Synonyms: Sovrima, idebenone, Catena, Cerestabon, Idebenonum, ...
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Disease relevance of idebenone


Psychiatry related information on idebenone


High impact information on idebenone


Chemical compound and disease context of idebenone


Biological context of idebenone


Anatomical context of idebenone


Associations of idebenone with other chemical compounds

  • Chenodeoxycholic acid concentrations increased to 5.15 nmol/10(6) cells after 2 h and to 7.05 after 4 h of incubation of hepatocytes with 1000 micromol/l TCDC, and did not differ in the presence of idebenone [4].
  • However, feeding the animals with idebenone over 7 days before explantation led to a faster recovery of ketone body ratio, paralleled by a substantial suppression of HSP70 expression [15].
  • There is some evidence to suggest that idebenone might function as an antioxidant; however, it has not been demonstrated whether this function pertains to the quinone or hydroquinone form of idebenone [16].
  • We have previously demonstrated that potent antioxidants idebenone and alpha-tocopherol prevent learning and memory impairment in rats which received a continuous intracerebroventricular infusion of amyloid beta, suggesting a role for oxidative stress in amyloid beta-induced learning and memory impairment [21].
  • The results indicate that treatment with idebenone provides significant protection against the neuronal degeneration induced by intrastriatal injection of kainic acid and quisqualic acid, but not the NMDA receptor agonist, quinolinic acid [22].

Gene context of idebenone


Analytical, diagnostic and therapeutic context of idebenone


  1. Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study. Rustin, P., von Kleist-Retzow, J.C., Chantrel-Groussard, K., Sidi, D., Munnich, A., Rötig, A. Lancet (1999) [Pubmed]
  2. Remission of Leber's hereditary optic neuropathy with idebenone. Mashima, Y., Hiida, Y., Oguchi, Y. Lancet (1992) [Pubmed]
  3. Idebenone delays the onset of cardiac functional alteration without correction of Fe-S enzymes deficit in a mouse model for Friedreich ataxia. Seznec, H., Simon, D., Monassier, L., Criqui-Filipe, P., Gansmuller, A., Rustin, P., Koenig, M., Puccio, H. Hum. Mol. Genet. (2004) [Pubmed]
  4. The effect of idebenone, a coenzyme Q analogue, on hydrophobic bile acid toxicity to isolated rat hepatocytes and hepatic mitochondria. Shivaram, K.N., Winklhofer-Roob, B.M., Straka, M.S., Devereaux, M.W., Everson, G., Mierau, G.W., Sokol, R.J. Free Radic. Biol. Med. (1998) [Pubmed]
  5. Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress. Rego, A.C., Santos, M.S., Oliveira, C.R. Free Radic. Biol. Med. (1999) [Pubmed]
  6. Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats. Ohta, H., Nishikawa, H., Kimura, H., Anayama, H., Miyamoto, M. Neuroscience (1997) [Pubmed]
  7. Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: update on a 2-year double-blind multicentre study. Gutzmann, H., Hadler, D. J. Neural Transm. Suppl. (1998) [Pubmed]
  8. A controlled trial of idebenone in Huntington's disease. Ranen, N.G., Peyser, C.E., Coyle, J.T., Bylsma, F.W., Sherr, M., Day, L., Folstein, M.F., Brandt, J., Ross, C.A., Folstein, S.E. Mov. Disord. (1996) [Pubmed]
  9. Protective properties of idebenone in noise-induced hearing loss in the guinea pig. Sergi, B., Fetoni, A.R., Paludetti, G., Ferraresi, A., Navarra, P., Mordente, A., Troiani, D. Neuroreport (2006) [Pubmed]
  10. Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Praticò, D., Delanty, N. Am. J. Med. (2000) [Pubmed]
  11. Idebenone acts against growth of Helicobacter pylori by inhibiting its respiration. Inatsu, S., Ohsaki, A., Nagata, K. Antimicrob. Agents Chemother. (2006) [Pubmed]
  12. Pharmacological effects of indeloxazine, a new cerebral activator, on brain functions distinct from other cerebral metabolic enhancers. Yamamoto, M., Kawabata, S., Shimizu, M. Neuropharmacology (1989) [Pubmed]
  13. Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia. Narumi, S., Nagai, Y., Kakihana, M., Yamazaki, N., Nagaoka, A., Nagawa, Y. Jpn. J. Pharmacol. (1985) [Pubmed]
  14. Effects of idebenone (CV-2619) on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral ischemia. Kakihana, M., Yamazaki, N., Nagaoka, A. Jpn. J. Pharmacol. (1984) [Pubmed]
  15. Acceleration of hepatocellular energy by idebenone during early reperfusion after cold preservation ameliorates heat shock protein 70 gene expression in a pig liver model. Schütz, E., Wieland, E., Heine, L., Hensel, A., Schmiedl, A., Armstrong, V.W., Richter, J., Schuff-Werner, P., Günther, E., Oellerich, M. Transplantation (1997) [Pubmed]
  16. Antioxidant properties of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (idebenone). Mordente, A., Martorana, G.E., Minotti, G., Giardina, B. Chem. Res. Toxicol. (1998) [Pubmed]
  17. Stimulation of the respiratory and phosphorylating activities in rat brain mitochondria by idebenone (CV-2619), a new agent improving cerebral metabolism. Sugiyama, Y., Fujita, T. FEBS Lett. (1985) [Pubmed]
  18. Idebenone and vinpocetine augment long-term potentiation in hippocampal slices in the guinea pig. Ishihara, K., Katsuki, H., Sugimura, M., Satoh, M. Neuropharmacology (1989) [Pubmed]
  19. Mitochondrial function is differentially affected upon oxidative stress. Cardoso, S.M., Pereira, C., Oliveira, R. Free Radic. Biol. Med. (1999) [Pubmed]
  20. Idebenone protects hepatic microsomes against oxygen radical-mediated damage in organ preservation solutions. Wieland, E., Schütz, E., Armstrong, V.W., Küthe, F., Heller, C., Oellerich, M. Transplantation (1995) [Pubmed]
  21. Immunocytochemical evidence that amyloid beta (1-42) impairs endogenous antioxidant systems in vivo. Kim, H.C., Yamada, K., Nitta, A., Olariu, A., Tran, M.H., Mizuno, M., Nakajima, A., Nagai, T., Kamei, H., Jhoo, W.K., Im, D.H., Shin, E.J., Hjelle, O.P., Ottersen, O.P., Park, S.C., Kato, K., Mirault, M.E., Nabeshima, T. Neuroscience (2003) [Pubmed]
  22. Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins. Miyamoto, M., Coyle, J.T. Exp. Neurol. (1990) [Pubmed]
  23. Leber's Hereditary Optic Neuropathy (LHON) with 14484/ND6 mutation in a North African patient. Carelli, V., Barboni, P., Zacchini, A., Mancini, R., Monari, L., Cevoli, S., Liguori, R., Sensi, M., Lugaresi, E., Montagna, P. J. Neurol. Sci. (1998) [Pubmed]
  24. The effects of idebenone on the superoxide dismutase, catalase and glutathione peroxidase activities in liver and brain homogenates, as well as in brain synaptosomal and mitochondrial fractions. Nagy, K., Zs -Nagy, I. Archives of gerontology and geriatrics. (1990) [Pubmed]
  25. Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS. Ikejiri, Y., Mori, E., Ishii, K., Nishimoto, K., Yasuda, M., Sasaki, M. Neurology (1996) [Pubmed]
  26. Neuroprotective effect of insulin-like growth factor I in immortalized hypothalamic cells. Sortino, M.A., Canonico, P.L. Endocrinology (1996) [Pubmed]
  27. Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats. Nitta, A., Murakami, Y., Furukawa, Y., Kawatsura, W., Hayashi, K., Yamada, K., Hasegawa, T., Nabeshima, T. Naunyn Schmiedebergs Arch. Pharmacol. (1994) [Pubmed]
  28. Determination of idebenone in rat serum and brain by high-performance liquid chromatography using platinum catalyst reduction and electrochemical detection. Wakabayashi, H., Nakajima, M., Yamato, S., Shimada, K. J. Chromatogr. (1992) [Pubmed]
  29. Effect of idebenone on in vivo serotonin release and serotonergic receptors in young and aged rats. Scavini, C., Rozza, A., Lanza, E., Favalli, L., Racagni, G., Brunello, N. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1996) [Pubmed]
  30. Idebenone in patients with Friedreich ataxia. Schöls, L., Vorgerd, M., Schillings, M., Skipka, G., Zange, J. Neurosci. Lett. (2001) [Pubmed]
  31. Mitochondrial encephalomyopathy (MELAS): pathological study and successful therapy with coenzyme Q10 and idebenone. Ihara, Y., Namba, R., Kuroda, S., Sato, T., Shirabe, T. J. Neurol. Sci. (1989) [Pubmed]
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