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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The effectiveness of chiropractic for treatment of low back pain: an update and attempt at statistical pooling.

OBJECTIVE: To determine the effectiveness of chiropractic treatment for patients with low back pain by means of a systematic review of the literature. DATA SOURCES: Randomized clinical trials (RCTs) on chiropractic were identified with a Medline and Embase search (1966-1995), by citation tracking, and by hand searching of the relevant chiropractic reference systems (CRAC and Index to Chiropractic Literature). STUDY SELECTION: All RCTs on low back pain that involved chiropractors as therapists. DATA EXTRACTION: Methodological quality was assessed independently by two reviewers on 14 items covering internal validity, informativeness and study size. Data were extracted on: patients (initial referral, duration of complaints, radiation of pain); outcomes (four different types); and timing of follow-up (short-term, intermediate and long-term). Statistical pooling was intended, according to a preset analysis plan, to include subgroup analysis. DATA SYNTHESIS: Eight RCTs were identified. All RCTs had serious flaws in their design, execution and reporting. Because of the great variety of outcome measures and follow-up timing, there was insufficient data to enable statistical pooling of the RCTs. A narrative review, however, did not provide convincing evidence for the effectiveness of chiropractic for acute or chronic low back pain. CONCLUSIONS: There is certainly a need for correctly executed trials. In future research on the effectiveness of chiropractic, guidelines for uniform execution and reporting of RCTs should first be established to enable subsequent statistical pooling in systematic reviews of chiropractic trials.[1]


  1. The effectiveness of chiropractic for treatment of low back pain: an update and attempt at statistical pooling. Assendelft, W.J., Koes, B.W., van der Heijden, G.J., Bouter, L.M. Journal of manipulative and physiological therapeutics. (1996) [Pubmed]
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