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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Bcl-2 targets the protein kinase Raf-1 to mitochondria.

A green fluorescent protein (GFP)-Raf-1 fusion protein was used to show that Bcl-2 can target this kinase to mitochondria. Active Raf-1 fused with targeting sequences from an outer mitochondrial membrane protein protected cells from apoptosis and resulted in phosphorylation of BAD, a proapoptotic Bcl-2 homolog. Plasma membrane-targeted Raf-1 did not protect from apoptosis and resulted in phosphorylation of ERK-1 and ERK-2. Untargeted active Raf-1 improved Bcl-2-mediated resistance to apoptosis, whereas a kinase-inactive Raf-1 mutant abrogated apoptosis suppression by Bcl-2. Bcl-2 can therefore target Raf-1 to mitochondrial membranes, allowing this kinase to phosphorylate BAD or possibly other protein substrates involved in apoptosis regulation.[1]


  1. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Wang, H.G., Rapp, U.R., Reed, J.C. Cell (1996) [Pubmed]
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