Gene Review:
RAF1 - Raf-1 proto-oncogene, serine/threonine kinase
Homo sapiens
Synonyms:
CMD1NN, CRAF, NS5, Proto-oncogene c-RAF, RAF, ...
Adnane,
Lee,
Lovric,
Conley,
Maestre,
McHugh,
Nicholls,
Whitmore,
Janosch,
Eveleigh,
Taylor,
Min,
Lynch,
Kim,
Liu,
Gedrich,
Rizavi,
Martial,
Dwivedi,
Abe,
Voznesensky,
D'Angelo,
Post,
Kimler,
Rowley,
Cao,
Mas,
Laurent,
Riordan,
Park,
Kolch,
Martini,
Vincent,
Riedl,
Hernandez,
Carter,
Kieser,
Park,
Zhang,
Park,
Lee,
Jaffrézou,
Bollag,
Quillet-Mary,
Kim,
Iiri,
Gray,
Sytkowski,
Shujath,
Pandey,
Gounari,
Mischak,
Reichert,
Filomenko,
Hahm,
Eulitz,
Sauer,
Azama,
McNabola,
Tang,
Rong,
Bezombes,
Büscher,
Demur,
Fantl,
Baccarini,
Plo,
Wilkie,
Park,
Trail,
Chen,
Lee,
Jung,
Weiner,
Auclair,
Wilhelm,
Chen,
Gawlak,
- High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer. Simon, R., Richter, J., Wagner, U., Fijan, A., Bruderer, J., Schmid, U., Ackermann, D., Maurer, R., Alund, G., Knönagel, H., Rist, M., Wilber, K., Anabitarte, M., Hering, F., Hardmeier, T., Schönenberger, A., Flury, R., Jäger, P., Fehr, J.L., Schraml, P., Moch, H., Mihatsch, M.J., Gasser, T., Sauter, G. Cancer Res. (2001)
- Involvement of the RAF1 locus, at band 3p25, in the 3p deletion of small-cell lung cancer. Graziano, S.L., Pfeifer, A.M., Testa, J.R., Mark, G.E., Johnson, B.E., Hallinan, E.J., Pettengill, O.S., Sorenson, G.D., Tatum, A.H., Brauch, H. Genes Chromosomes Cancer (1991)
- The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner. Xia, K., Mukhopadhyay, N.K., Inhorn, R.C., Barber, D.L., Rose, P.E., Lee, R.S., Narsimhan, R.P., D'Andrea, A.D., Griffin, J.D., Roberts, T.M. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Activated protooncogenes in human lung tumors from smokers. Reynolds, S.H., Anna, C.K., Brown, K.C., Wiest, J.S., Beattie, E.J., Pero, R.W., Iglehart, J.D., Anderson, M.W. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway. Bian, D., Su, S., Mahanivong, C., Cheng, R.K., Han, Q., Pan, Z.K., Sun, P., Huang, S. Cancer Res. (2004)
- Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Razzaque, M.A., Nishizawa, T., Komoike, Y., Yagi, H., Furutani, M., Amo, R., Kamisago, M., Momma, K., Katayama, H., Nakagawa, M., Fujiwara, Y., Matsushima, M., Mizuno, K., Tokuyama, M., Hirota, H., Muneuchi, J., Higashinakagawa, T., Matsuoka, R. Nat. Genet. (2007)
- Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. Mei, M., Su, B., Harrison, K., Chao, M., Siedlak, S.L., Previll, L.A., Jackson, L., Cai, D.X., Zhu, X. J. Neurochem. (2006)
- High frequency of BRAF mutations in nevi. Pollock, P.M., Harper, U.L., Hansen, K.S., Yudt, L.M., Stark, M., Robbins, C.M., Moses, T.Y., Hostetter, G., Wagner, U., Kakareka, J., Salem, G., Pohida, T., Heenan, P., Duray, P., Kallioniemi, O., Hayward, N.K., Trent, J.M., Meltzer, P.S. Nat. Genet. (2003)
- Kinase suppressor of Ras is ceramide-activated protein kinase. Zhang, Y., Yao, B., Delikat, S., Bayoumy, S., Lin, X.H., Basu, S., McGinley, M., Chan-Hui, P.Y., Lichenstein, H., Kolesnick, R. Cell (1997)
- Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Hughes, P.E., Renshaw, M.W., Pfaff, M., Forsyth, J., Keivens, V.M., Schwartz, M.A., Ginsberg, M.H. Cell (1997)
- Bcl-2 targets the protein kinase Raf-1 to mitochondria. Wang, H.G., Rapp, U.R., Reed, J.C. Cell (1996)
- Activation of the Raf-1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells. Nemoto, K., Vogt, A., Oguri, T., Lazo, J.S. Prostate (2004)
- Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. Pal, A., Ahmad, A., Khan, S., Sakabe, I., Zhang, C., Kasid, U.N., Ahmad, I. Int. J. Oncol. (2005)
- Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228. Yu, X., Guo, Z.S., Marcu, M.G., Neckers, L., Nguyen, D.M., Chen, G.A., Schrump, D.S. J. Natl. Cancer Inst. (2002)
- Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter. Flory, E., Hoffmeyer, A., Smola, U., Rapp, U.R., Bruder, J.T. J. Virol. (1996)
- Activation of Raf1 and the ERK pathway in response to l-ascorbic acid in acute myeloid leukemia cells. Park, S., Park, C.H., Hahm, E.R., Kim, K., Kimler, B.F., Lee, S.J., Park, H.K., Lee, S.H., Kim, W.S., Jung, C.W., Park, K., Riordan, H.D., Lee, J.H. Cell. Signal. (2005)
- Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene. Gray, T.A., Azama, K., Whitmore, K., Min, A., Abe, S., Nicholls, R.D. Genomics (2001)
- Confirmation of linkage in von Hippel-Lindau disease. Vance, J.M., Small, K.W., Jones, M.A., Stajich, J.M., Yamaoka, L.H., Roses, A.D., Hung, W.Y., Pericak-Vance, M.A. Genomics (1990)
- Physical mapping of chromosome 3p25-p26 by fluorescence in situ hybridisation (FISH). Phipps, M.E., Maher, E.R., Affara, N.A., Latif, F., Leversha, M.A., Ferguson-Smith, M.E., Nakamura, Y., Lerman, M., Zbar, B., Ferguson-Smith, M.A. Hum. Genet. (1993)
- RAF1-activated MEK1 is found on the Golgi apparatus in late prophase and is required for Golgi complex fragmentation in mitosis. Colanzi, A., Sutterlin, C., Malhotra, V. J. Cell Biol. (2003)
- Translocation (3;5)(p26;q13) in a patient with chronic T-cell lymphoproliferative disorder. Schmidt, H.H., Pirc-Danoewinata, H., Panzer-Grümayer, E.R., Sill, H., Sedlmayr, P., Neumeister, P., Linkesch, W., Haas, O.A. Cancer Genet. Cytogenet. (1998)
- Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Lin, A., Minden, A., Martinetto, H., Claret, F.X., Lange-Carter, C., Mercurio, F., Johnson, G.L., Karin, M. Science (1995)
- Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Garnett, M.J., Rana, S., Paterson, H., Barford, D., Marais, R. Mol. Cell (2005)
- Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Sasaki, A., Taketomi, T., Kato, R., Saeki, K., Nonami, A., Sasaki, M., Kuriyama, M., Saito, N., Shibuya, M., Yoshimura, A. Nat. Cell Biol. (2003)
- Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro. Macdonald, S.G., Crews, C.M., Wu, L., Driller, J., Clark, R., Erikson, R.L., McCormick, F. Mol. Cell. Biol. (1993)
- Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade. Vrana, J.A., Grant, S. Blood (2001)
- Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways. Jia, W., Yu, C., Rahmani, M., Krystal, G., Sausville, E.A., Dent, P., Grant, S. Blood (2003)
- B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding. Fischer, A., Hekman, M., Kuhlmann, J., Rubio, I., Wiese, S., Rapp, U.R. J. Biol. Chem. (2007)
- Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Chen, J., Fujii, K., Zhang, L., Roberts, T., Fu, H. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Chadee, D.N., Xu, D., Hung, G., Andalibi, A., Lim, D.J., Luo, Z., Gutmann, D.H., Kyriakis, J.M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells. Dang, A., Frost, J.A., Cobb, M.H. J. Biol. Chem. (1998)
- A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization. Wang, X., Li, N., Liu, B., Sun, H., Chen, T., Li, H., Qiu, J., Zhang, L., Wan, T., Cao, X. J. Biol. Chem. (2004)
- Rac-1 and Raf-1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinase. Shimizu, M., Wang, W., Walch, E.T., Dunne, P.W., Epstein, H.F. FEBS Lett. (2000)
- Identification of a C-terminal region that regulates mitogen-activated protein kinase kinase-1 cytoplasmic localization and ERK activation. Cha, H., Lee, E.K., Shapiro, P. J. Biol. Chem. (2001)
- Apoptosis-linked gene-2 connects the Raf-1 and ASK1 signalings. Chen, C., Sytkowski, A.J. Biochem. Biophys. Res. Commun. (2005)
- Retinoic acid increases amount of phosphorylated RAF; ectopic expression of cFMS reveals that retinoic acid-induced differentiation is more strongly dependent on ERK2 signaling than induced GO arrest is. Yen, A., Varvayanis, S. In Vitro Cell. Dev. Biol. Anim. (2000)
- The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway. Boehm, M.B., Milius, T.J., Zhou, Y., Westendorf, J.J., Koka, S. Biochem. Biophys. Res. Commun. (2005)
- The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments. Janosch, P., Kieser, A., Eulitz, M., Lovric, J., Sauer, G., Reichert, M., Gounari, F., Büscher, D., Baccarini, M., Mischak, H., Kolch, W. FASEB J. (2000)
- Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin. Mas, V.M., Hernandez, H., Plo, I., Bezombes, C., Maestre, N., Quillet-Mary, A., Filomenko, R., Demur, C., Jaffrézou, J.P., Laurent, G. Blood (2003)
- Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. Wu, X., Noh, S.J., Zhou, G., Dixon, J.E., Guan, K.L. J. Biol. Chem. (1996)
- Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition. Tran, N.H., Frost, J.A. J. Biol. Chem. (2003)
- 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells. D'Angelo, G., Martini, J.F., Iiri, T., Fantl, W.J., Martial, J., Weiner, R.I. Mol. Endocrinol. (1999)
- Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). Pagès, G., Brunet, A., L'Allemain, G., Pouysségur, J. EMBO J. (1994)
- Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases. Berberich, I., Shu, G., Siebelt, F., Woodgett, J.R., Kyriakis, J.M., Clark, E.A. EMBO J. (1996)
- Protein binding and signaling properties of RIN1 suggest a unique effector function. Han, L., Wong, D., Dhaka, A., Afar, D., White, M., Xie, W., Herschman, H., Witte, O., Colicelli, J. Proc. Natl. Acad. Sci. U.S.A. (1997)
- BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Wilhelm, S.M., Carter, C., Tang, L., Wilkie, D., McNabola, A., Rong, H., Chen, C., Zhang, X., Vincent, P., McHugh, M., Cao, Y., Shujath, J., Gawlak, S., Eveleigh, D., Rowley, B., Liu, L., Adnane, L., Lynch, M., Auclair, D., Taylor, I., Gedrich, R., Voznesensky, A., Riedl, B., Post, L.E., Bollag, G., Trail, P.A. Cancer Res. (2004)
- ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf. Dwivedi, Y., Rizavi, H.S., Conley, R.R., Pandey, G.N. Mol. Psychiatry (2006)