Regulation of S100P expression by androgen.
BACKGROUND: The growth and function the normal prostate is dependent on the presence of androgen. As prostate tumors progress there is a loss of androgen-dependent cell growth. The identification of the genes that are regulated by androgens may be of pathological and clinical significance. METHODS: In this study the differential display method was used to identify genes regulated by androgen in an androgen-responsive prostate cancer cell line, LNCaP-FGC. RESULTS: A gene whose expression is down-regulated in LNCaP-FGC cells after 30 hr of androgen deprivation has been identified. This gene is a previously identified member of the S100 gene family of calcium-binding proteins, namely S100P. Here we show that S100P expression is regulated by the synthetic androgen R1881, but not by serum growth factors. It is dysregulated in the androgen-independent prostate cancer cell lines LNCaP-R, DU145, and PC3. CONCLUSIONS: The data indicate that S100P may play a role in the etiology of prostate cancer.[1]References
- Regulation of S100P expression by androgen. Averboukh, L., Liang, P., Kantoff, P.W., Pardee, A.B. Prostate (1996) [Pubmed]
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