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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

METRIBOLONE     (8S,13R,14S,17S)-17-hydroxy- 13,17-dimethyl...

Synonyms: Metribolona, Metribolonum, CHEMBL166444, SureCN114862, R-1881, ...
 
 
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Disease relevance of R 1881

 

High impact information on R 1881

 

Chemical compound and disease context of R 1881

 

Biological context of R 1881

 

Anatomical context of R 1881

 

Associations of R 1881 with other chemical compounds

 

Gene context of R 1881

  • Insulin-like growth factor-I (IGF-I), at a concentration of 50 ng/ml, stimulated AR-mediated reporter gene transcription to the same extent as the synthetic androgen methyltrienolone [25].
  • Real-time PCR showed a significant increase in NAT1 mRNA levels for R1881-treated cells (6.60 +/- 0.80) compared with vehicle-treated controls (1.53 +/- 0.17), which was not due to a change in mRNA stability [16].
  • Growth of hormone-dependent LNCaP cells in hormone-depleted media led to increased WNT11 expression, which was repressed by the synthetic androgen R1881 [26].
  • Induction of cyclin A1 expression in LNCaP cells led to an increase in VEGF expression and this effect was manifested upon the R1881 treatment [27].
  • In MDA-MB-453 cells, which express the AR but not the ER or PR, DHT and R1881 increased PRLR binding to 150% of control values at 0.1 nM [28].
 

Analytical, diagnostic and therapeutic context of R 1881

References

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