Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Bieber, H. et al.

Microevolution and genetic affinities among six Amerindian tribes of lower Central America: comparative genetic study of serum proteins.

We evaluate the pattern of genetic variation among native Mesoamerican Amerindians by the construction of a gene frequency map that reflects the past action of evolutionary forces. The analysis is based on the theory that genes of modern human populations carry the encoded history even of humans' remote past and their early wanderings around the globe. We examined the serum proteins TF, PI, F13B and AHSG on 491 samples of 6 Mesoamerican Amerindian tribes (Guaymi, Bribri, Cabecar, Teribe, Guatuso, and Huetar) and 2 tribal mixed samples (Teribe x Guaymi and Bribri x Cabecar). We find a distinct genetic pattern in the examined tribes that clearly separates the Mesoamerican Amerindians from other living Amerindian groups. The proteins, TF, PI, and AHSG proved to be especially rich in special genetically fixed variants and polymorphisms, and F13B proved to be a powerful genetic marker to distinguish human groups. Using Nei's distance D and Mahalanobis's D2, we compared the polymorphisms and allele frequencies at the four serum protein loci to discern degrees of similarity between the samples. These data are presented in the dendrograms computed by average linkage cluster analyses and in two kinds of unrooted phylogenetic trees, neighbor-joining trees and split decompositions. Estimations are made on Hardy-Weinberg equilibrium and on genetic diversity and average heterozygosity index.[1]

References

Microevolution and genetic affinities among six Amerindian tribes of lower Central America: comparative genetic study of serum proteins. Bieber, H., Bieber, S.W., Rodewald, A., Barrantes, R. Hum. Biol. (1996) [Pubmed]

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