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Gene Review

F13B  -  coagulation factor XIII, B polypeptide

Homo sapiens

Synonyms: Coagulation factor XIII B chain, FXIIIB, Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain
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Disease relevance of F13B


High impact information on F13B

  • Nine populations (Germans, Turks, Moroccans, Ovambos, Ugandans, Chinese, Japanese, Papuans, and Australian Aborigines) were investigated using six microsatellite systems (HumCD4, Hum F13B, HumFES/FPS, HumTH01, HumVWA, and D21S11), so-called STRs (short tandem repeats) [4].
  • After preliminary studies demonstrated the cPLA2 gene is expressed in a variety of human tissues and was localized to the q arm of chromosome 1 between markers F13B and D1S74, we cloned and characterized the 5'-flanking region of this gene in order to identify the elements controlling its low level constitutive expression [5].
  • For the determination of VNTR locus (D1S80) and the ten STR loci (vWA, F13B, TH01, TPOX, CSF1PO, F13A01, LPL, D3S1744, D12S1090, D18S849) we used polymerase chain reaction (PCR) amplification and the vertical polyacrylamide gel electrophoresis technique followed by SYBR green I staining [6].
  • Our data suggest the presence of a putative tumor suppressor gene located near the locus F13B on chromosome arm 1q that appears to be involved in the pathogenesis of medulloblastoma [2].
  • PIGR versus F13B showed + 1.46 at theta max = 0.25 for both sexes combined [7].

Biological context of F13B

  • Here we present the first genetic linkage study of PIGR versus syntenic markers, including D1S58 and F13B, which have been previously regionalized to 1q31-q32 and 1q31-q32.1, respectively [7].
  • Localization of the coagulation factor XIII B subunit gene (F13B) to chromosome bands 1q31-32.1 and restriction fragment length polymorphism at the locus [8].
  • In situ hybridization of tritiated cDNA probes for the gene for the B subunit of coagulation factor XIII localized the F13B locus to bands q31-q32.1 on human chromosome 1 and perhaps more precisely to sub-bands 1q31.2 or 1q31 [8].
  • This will mean that the F13B gene can hardly be located on the chromosomes/chromosome arms 1p, 2p, 4q, 6p, 14p, 15p, 20q, 21p, 22 and also not on longer segments of 3q, 6q, 7q, 9p, 9q, 11q, 13q, 14q, 16p, and 16q [9].
  • The contig orders the F13B and HF1 genes, as well as five expressed sequence tags, with respect to the integrated genetic map of this region [10].

Anatomical context of F13B


Associations of F13B with chemical compounds

  • Linkage analyses of human peptidase C (PEPC), human factor H (HF), and coagulation factor XIIIB (F13B) [11].
  • Significant associations of F13B 2 allotype [p = 0.0220, relative risk (RR) = 13.9] and IF A allotype (p = 0.0006, RR = 10.0) with PVV were observed; however, no significant association of PLG, C6, C7 or BF allotype with the disease was found [1].
  • The FFFL Multiplex System is composed of the loci F13A01, FESFPS, F13B, and LPL, each labeled with fluorescein [12].

Other interactions of F13B


Analytical, diagnostic and therapeutic context of F13B


  1. Polymorphisms of serum proteins in Japanese patients with vascular diseases. I. Factor XIIIB, plasminogen and complement types in primary varicose veins. Mizutani, K., Nishimukai, H., Yasugi, T., Iwahashi, K., Tsunekawa, K., Shinomiya, T. Hum. Hered. (1991) [Pubmed]
  2. Loss of heterozygosity at locus F13B on chromosome 1q in human medulloblastoma. Kraus, J.A., Koch, A., Albrecht, S., Von Deimling, A., Wiestler, O.D., Pietsch, T. Int. J. Cancer (1996) [Pubmed]
  3. Cystic fibrosis; hint of linkage with F13B. Eiberg, H., Schmiegelow, K., Koch, C., Mohr, J., Schwartz, M., Niebuhr, E. Clin. Genet. (1985) [Pubmed]
  4. Population genetic diversity in relation to microsatellite heterogeneity. Brinkmann, B., Junge, A., Meyer, E., Wiegand, P. Hum. Mutat. (1998) [Pubmed]
  5. Identification of a 27 bp 5'-flanking region element responsible for the low level constitutive expression of the human cytosolic phospholipase A2 gene. Miyashita, A., Crystal, R.G., Hay, J.G. Nucleic Acids Res. (1995) [Pubmed]
  6. Application of electrophoresis technology to DNA analysis. Wang, X., Sawaguchi, T., Sawaguchi, A. Electrophoresis (2000) [Pubmed]
  7. The gene encoding human transmembrane secretory component (locus PIGR) is linked to D1S58 on chromosome 1. Krajci, P., Gedde-Dahl, T., Høyheim, B., Rogde, S., Olaisen, B., Brandtzaeg, P. Hum. Genet. (1992) [Pubmed]
  8. Localization of the coagulation factor XIII B subunit gene (F13B) to chromosome bands 1q31-32.1 and restriction fragment length polymorphism at the locus. Webb, G.C., Coggan, M., Ichinose, A., Board, P.G. Hum. Genet. (1989) [Pubmed]
  9. Coagulation factor XIII: genetic linkage studies with F13B. Bender, K., Bissbort, S., Klein, A., Mauff, G., Mayerová, A., Nagel, M., Schilling, A., Wienker, T.F. Genet. Epidemiol. (1987) [Pubmed]
  10. Integrated genetic and physical map of the 1q31-->q32.1 region, encompassing the RP12 locus, the F13B and HF1 genes, and the EEF1AL11 and RPL30 pseudogenes. van Soest, S., van Rossem, M.J., Heckenlively, J.R., van den Born, L.I., de Meulemeester, T.M., Vliex, S., de Jong, P.T., Bleeker-Wagemakers, E.M., Westerveld, A., Bergen, A.A. Cytogenet. Cell Genet. (1999) [Pubmed]
  11. Linkage analyses of human peptidase C (PEPC), human factor H (HF), and coagulation factor XIIIB (F13B). Kömpf, J., Luckenbach, C., Kloor, D., Krczal, D., Amorim, A., Ritter, H. Hum. Genet. (1989) [Pubmed]
  12. TWGDAM validation of a nine-locus and a four-locus fluorescent STR multiplex system. Micka, K.A., Amiott, E.A., Hockenberry, T.L., Sprecher, C.J., Lins, A.M., Rabbach, D.R., Taylor, J.A., Bacher, J.W., Glidewell, D.E., Gibson, S.D., Crouse, C.A., Schumm, J.W. J. Forensic Sci. (1999) [Pubmed]
  13. Genetic study of African populations: polymorphisms of the plasma proteins TF, PL, F13B, and AHSG in populations of Namibia and Mozambique. Bieber, H., Bieber, S.W., Rodewald, A., Christiansen, K. Hum. Biol. (1997) [Pubmed]
  14. A patient defines the interstitial 1q deletion syndrome characterized by antithrombin III deficiency. Pallotta, R., Dalprà, L., Miozzo, M., Ehresmann, T., Fusilli, P. Am. J. Med. Genet. (2001) [Pubmed]
  15. F13B and CD4 allele frequencies in south west Switzerland. Dimo-Simonin, N., Grange, F., Brandt-Casadevall, C. Int. J. Legal Med. (1997) [Pubmed]
  16. Phenotype differences of STRs in 7 human populations. Meyer, E., Wiegand, P., Brinkmann, B. Int. J. Legal Med. (1995) [Pubmed]
  17. F13B and CD4 allele frequencies in an Austrian population sample. Neuhuber, F., Radacher, M., Krasa, B. Int. J. Legal Med. (1996) [Pubmed]
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