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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Sustained-release methylphenidate for cognitive impairment in HIV-1-infected drug abusers: a pilot study.

Other investigators have reported clinical improvement from psychostimulant drugs in patients with HIV-1-related cognitive impairment. However, no previous research has substantiated this claim by using a controlled study design. We examined the efficacy of sustained-release methylphenidate ( MSR) in a sample of substance abusers with HIV-1-related cognitive impairment. Eight HIV-1-infected methadone patients with impaired neuropsychological test performance participated in an inpatient double-blind placebo-controlled crossover trial of MSR 20-40 mg/day. On a composite neuropsychological measure, patients improved significantly from baseline during MSR but not placebo treatment. Nevertheless, MSR performance did not differ significantly from placebo performance. Patients appeared to improve as a function of time, regardless of sequence, with somewhat more improvement during MSR than placebo treatment.[1]

References

  1. Sustained-release methylphenidate for cognitive impairment in HIV-1-infected drug abusers: a pilot study. van Dyck, C.H., McMahon, T.J., Rosen, M.I., O'Malley, S.S., O'Connor, P.G., Lin, C.H., Pearsall, H.R., Woods, S.W., Kosten, T.R. The Journal of neuropsychiatry and clinical neurosciences. (1997) [Pubmed]
 
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