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Luna, T. et al.

Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis.

A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA), was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.[1]

References

Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis. Luna, T., Mazzolla, R., Romanò, G., Blasi, E. Antimicrob. Agents Chemother. (1997) [Pubmed]

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