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Chemical Compound Review

Fungizone     (1R,3S,5R,6R,9R,11R,15S,16R,17 R,18S,33R...

Synonyms: SMP1_000302, AC1L24V6, 1397-89-3, NCGC00179595-01, Amphotericin B solution, ...
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Disease relevance of amphotericin b


Psychiatry related information on amphotericin b


High impact information on amphotericin b


Chemical compound and disease context of amphotericin b


Biological context of amphotericin b


Anatomical context of amphotericin b


Associations of amphotericin b with other chemical compounds


Gene context of amphotericin b

  • These data demonstrate that TLR2 and CD14 are required for amphotericin B-dependent inflammatory stimulation of innate immune cells and that TLR4 may also provide stimulation of these cells [26].
  • Primary murine macrophages and human cell lines expressing TLR2, CD14, and the adapter protein MyD88 responded to amphotericin B with NF-kappaB-dependent reporter activity and cytokine release, whereas cells deficient in any of these failed to respond [26].
  • Cells mutated in TLR4 were less responsive to amphotericin B stimulation than cells expressing normal TLR4 [26].
  • The 24-alkylated sterols have been shown previously to be absent in membranes of amphotericin B (AmB)-resistant Leishmania donovani promastigotes, suggesting that the S- adenosyl-l-methionine:C-24-Delta-sterol-methyltransferase (SCMT or ERG6) was not functional or not expressed in AmB-resistant (AmB-R) parasites [27].
  • Amphotericin B also induced expression of ICAM-1 but not CD44 in these cells [28].

Analytical, diagnostic and therapeutic context of amphotericin b


  1. Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group. Walsh, T.J., Finberg, R.W., Arndt, C., Hiemenz, J., Schwartz, C., Bodensteiner, D., Pappas, P., Seibel, N., Greenberg, R.N., Dummer, S., Schuster, M., Holcenberg, J.S. N. Engl. J. Med. (1999) [Pubmed]
  2. Amphotericin B nasal spray as prophylaxis against aspergillosis in patients with neutropenia. Meunier-Carpentier, F., Snoeck, R., Gerain, J., Muller, C., Klastersky, J. N. Engl. J. Med. (1984) [Pubmed]
  3. Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis. The NIAID Mycoses Study Group and the AIDS Clinical Trials Group. Saag, M.S., Powderly, W.G., Cloud, G.A., Robinson, P., Grieco, M.H., Sharkey, P.K., Thompson, S.E., Sugar, A.M., Tuazon, C.U., Fisher, J.F. N. Engl. J. Med. (1992) [Pubmed]
  4. A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. Candidemia Study Group and the National Institute. Rex, J.H., Bennett, J.E., Sugar, A.M., Pappas, P.G., van der Horst, C.M., Edwards, J.E., Washburn, R.G., Scheld, W.M., Karchmer, A.W., Dine, A.P. N. Engl. J. Med. (1994) [Pubmed]
  5. Failure to ameliorate Creutzfeldt-Jakob disease with amphotericin B therapy. Masullo, C., Macchi, G., Xi, Y.G., Pocchiari, M. J. Infect. Dis. (1992) [Pubmed]
  6. Comparative neurotoxicities of amphotericin B and its mono-methyl ester derivative in rats. Reuhl, K.R., Vapiwala, M., Ryzlak, M.T., Schaffner, C.P. Antimicrob. Agents Chemother. (1993) [Pubmed]
  7. Orointestinal yeast colonization of paediatric oncologic patients during antifungal prophylaxis: results of quantitative culture and Candida serology and comparison of three polyenes. Hoppe, J.E., Friess, D., Niethammer, D. Mycoses (1995) [Pubmed]
  8. A Randomized, Blinded, Multicenter Trial of Lipid-Associated Amphotericin B Alone versus in Combination with an Antibody-Based Inhibitor of Heat Shock Protein 90 in Patients with Invasive Candidiasis. Pachl, J., Svoboda, P., Jacobs, F., Vandewoude, K., Hoven, B., Spronk, P., Masterson, G., Malbrain, M., Aoun, M., Garbino, J., Takala, J., Drgona, L., Burnie, J., Matthews, R. Clin. Infect. Dis. (2006) [Pubmed]
  9. Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Mycoses Study Group and AIDS Clinical Trials Group. van der Horst, C.M., Saag, M.S., Cloud, G.A., Hamill, R.J., Graybill, J.R., Sobel, J.D., Johnson, P.C., Tuazon, C.U., Kerkering, T., Moskovitz, B.L., Powderly, W.G., Dismukes, W.E. N. Engl. J. Med. (1997) [Pubmed]
  10. A controlled trial of fluconazole or amphotericin B to prevent relapse of cryptococcal meningitis in patients with the acquired immunodeficiency syndrome. The NIAID AIDS Clinical Trials Group and Mycoses Study Group. Powderly, W.G., Saag, M.S., Cloud, G.A., Robinson, P., Meyer, R.D., Jacobson, J.M., Graybill, J.R., Sugar, A.M., McAuliffe, V.J., Follansbee, S.E. N. Engl. J. Med. (1992) [Pubmed]
  11. A controlled trial in intensive care units of selective decontamination of the digestive tract with nonabsorbable antibiotics. The French Study Group on Selective Decontamination of the Digestive Tract. Gastinne, H., Wolff, M., Delatour, F., Faurisson, F., Chevret, S. N. Engl. J. Med. (1992) [Pubmed]
  12. Progressive disseminated histoplasmosis; favorable response to ketoconazole. Hawkins, S.S., Gregory, D.W., Alford, R.H. Ann. Intern. Med. (1981) [Pubmed]
  13. Histoplasmosis: a clinical and laboratory update. Kauffman, C.A. Clin. Microbiol. Rev. (2007) [Pubmed]
  14. Improved outcome in central nervous system aspergillosis, using voriconazole treatment. Schwartz, S., Ruhnke, M., Ribaud, P., Corey, L., Driscoll, T., Cornely, O.A., Schuler, U., Lutsar, I., Troke, P., Thiel, E. Blood (2005) [Pubmed]
  15. Isolation and characterization of amphotericin B-resistant cell lines in Chinese hamster cells. Hidaka, K., Endo, H., Akiyama, S., Kuwano, M. Cell (1978) [Pubmed]
  16. Direct vasoconstriction as a possible cause for amphotericin B-induced nephrotoxicity in rats. Sawaya, B.P., Weihprecht, H., Campbell, W.R., Lorenz, J.N., Webb, R.C., Briggs, J.P., Schnermann, J. J. Clin. Invest. (1991) [Pubmed]
  17. Ketoconazole versus nystatin plus amphotericin B for fungal prophylaxis in severely immunocompromised patients. Hann, I.M., Prentice, H.G., Corringham, R., Blacklock, H.A., Keaney, M., Shannon, M., Noone, P., Gascoigne, E., Fox, J., Boesen, E., Szawatkowski, M., Hoffbrand, A.V. Lancet (1982) [Pubmed]
  18. Triple regimen of selective decontamination of the digestive tract, systemic cefotaxime, and microbiological surveillance for prevention of acquired infection in intensive care. Ledingham, I.M., Alcock, S.R., Eastaway, A.T., McDonald, J.C., McKay, I.C., Ramsay, G. Lancet (1988) [Pubmed]
  19. Acute pulmonary decompensation due to amphotericin B in the absence of granulocyte transfusions. Haber, R.H., Oddone, E.Z., Gurbel, P.A., Stead, W.W. N. Engl. J. Med. (1986) [Pubmed]
  20. The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera. Rufo, P.A., Merlin, D., Riegler, M., Ferguson-Maltzman, M.H., Dickinson, B.L., Brugnara, C., Alper, S.L., Lencer, W.I. J. Clin. Invest. (1997) [Pubmed]
  21. Blastomycosis of the esophagus presenting with gastrointestinal bleeding. McKenzie, R., Khakoo, R. Gastroenterology (1985) [Pubmed]
  22. Combined amphotericin B-flucytosine therapy in Aspergillus pneumonia. Codish, S.D., Tobias, J.S., Hannigan, M. JAMA (1979) [Pubmed]
  23. Problems in the design and reporting of trials of antifungal agents encountered during meta-analysis. Johansen, H.K., Gotzsche, P.C. JAMA (1999) [Pubmed]
  24. A murine model for central nervous system leukemia and its possible relevance to human leukemia. Lynch, R.G., Medoff, G., Valeriote, F. J. Natl. Cancer Inst. (1975) [Pubmed]
  25. Imidazoles, ketoconazole, amphotericin B, and Candida guilliermondii. Wilson, G., Peacock, J.E. Ann. Intern. Med. (1985) [Pubmed]
  26. The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism. Sau, K., Mambula, S.S., Latz, E., Henneke, P., Golenbock, D.T., Levitz, S.M. J. Biol. Chem. (2003) [Pubmed]
  27. Cloning of S-adenosyl-L-methionine:C-24-Delta-sterol-methyltransferase (ERG6) from Leishmania donovani and characterization of mRNAs in wild-type and amphotericin B-Resistant promastigotes. Pourshafie, M., Morand, S., Virion, A., Rakotomanga, M., Dupuy, C., Loiseau, P.M. Antimicrob. Agents Chemother. (2004) [Pubmed]
  28. Amphotericin B induces expression of genes encoding chemokines and cell adhesion molecules in the human monocytic cell line THP-1. Rogers, P.D., Stiles, J.K., Chapman, S.W., Cleary, J.D. J. Infect. Dis. (2000) [Pubmed]
  29. Gastric candidiasis. Piken, E., Dwyer, R., Zablen, M.A. JAMA (1978) [Pubmed]
  30. Postpartum Candida endophthalmitis. Cantrill, H.L., Rodman, W.P., Ramsay, R.C., Knobloch, W.H. JAMA (1980) [Pubmed]
  31. Oral amphotericin for candidiasis in patients with hematologic neoplasms. An autopsy study. Ezdinli, E.Z., O'Sullivan, D.D., Wasser, L.P., Kim, U., Stutzman, L. JAMA (1979) [Pubmed]
  32. Focal hepatic candidiasis with perihepatic adhesions: laparoscopic and immunohistologic diagnosis. Gordon, S.C., Watts, J.C., Veneri, R.J., Chandler, F.W. Gastroenterology (1990) [Pubmed]
  33. Sporotrichosis arthritis: clinical features in seven patients. Crout, J.E., Brewer, N.S., Tompkins, R.B. Ann. Intern. Med. (1977) [Pubmed]
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