Disease relevance of Meningoencephalitis

• A strain of Listeria monocytogenes, isolated from a patient with meningoencephalitis, was resistant to chloramphenicol, erythromycin, streptomycin, and tetracycline [1].
• Inhibition of immune-mediated meningoencephalitis in persistently Borna disease virus-infected rats by cyclosporine A [2].
• This was done through analysis of CXCL10-deficient mice infected intracerebrally with lymphocytic choriomeningitis virus, which in normal immunocompetent mice induces a fatal CD8(+) T cell-mediated meningoencephalitis [3].
• In 19 treatment courses among 14 patients with meningoencephalitis or recurrent meningitis, eight of nine patients treated with chlorambucil had remission of their disease; eight of 10 treatment courses with other agents--generally, corticosteroids--failed to induce remission in any of eight patients [4].
• Chlorambucil in the treatment of uveitis and meningoencephalitis of Behçet's disease [4].

Psychiatry related information on Meningoencephalitis

• However, the 14-3-3 protein is a normal cellular protein expressed in various tissues, and its presence in CSF reflects extensive destruction of brain tissue as in CJD, but also in ischemic stroke and meningoencephalitis [5].

High impact information on Meningoencephalitis

• Acute meningoencephalitis. Association with isoniazid administration [6].
• The virus strains with the WSN gene segment coding for neuraminidase induced meningoencephalitis in mice [7].
• However, a human trial of Abeta immunization led to meningoencephalitis in some patients and was discontinued [8].
• Other potentially useful treatments, such as pleconaril for enteroviral meningoencephalitis are under clinical evaluation [9].
• Association of human parvovirus B19 infection with acute meningoencephalitis [10].

Chemical compound and disease context of Meningoencephalitis

• Amphotericin B doses for primary amoebic meningoencephalitis [11].
• Subcurative treatment with diminazene aceturate, which did not clear parasites from the central nervous system, resulted in a post-treatment meningoencephalitis similar to that seen in man [12].
• Aseptic meningoencephalitis after iopamidol myelography [13].
• Acute meningoencephalitis on dose reduction of zidovudine [14].
• Ibuprofen and meningoencephalitis [15].

Biological context of Meningoencephalitis

• Polymorphism of the cytotoxic T lymphocyte antigen-4 (CTLA-4) at position 49 of exon 1 showed a higher frequency of G/G genotype in patients with EV 71 meningoencephalitis than in those without meningoencephalitis (18/31 vs. 14/47; P=.045) and in control subjects (18/31 vs. 25/93l; P=.007) [16].
• Lastly, the reactivation of meningoencephalitis in immunosuppressed chronically infected mice was associated with VCAM-1 up-regulation [17].
• It causes an insidious form of meningitis characterized by headache, low-grade fever, stiff neck and cranial nerve palsies, and an acute meningoencephalitis characterized by coma, raised intracranial pressure, seizures, and focal neurological deficits [18].
• Brainstem auditory evoked responses in coma due to meningoencephalitis [19].
• The balance between host immunity and the virulence of the causative virus may be involved in the prognosis of meningoencephalitis in XLA [20].

Anatomical context of Meningoencephalitis

• However, although Abeta immunization did not show T cell infiltrates in the brain of these mice, an Abeta vaccination trial resulted in meningoencephalitis in 6% of patients with AD [21].
• Gadolinium-enhanced magnetic resonance imaging and analysis of cerebrospinal fluid revealed CMV ventriculitis and meningoencephalitis [22].
• Transcripts for the macrophage inflammatory protein-1 and tumor necrosis factor-alpha were first detected on day 21 postinfection, with higher levels in mice after development of the posttreatment meningoencephalitis, whereas granulocyte macrophage-colony stimulating factor was detected only in animals that developed posttreatment reaction [23].
• Our report is the first that describes a patient with SLE with herpes meningoencephalitis, transverse myelitis, and rapidly progressive outer retinal necrosis, diagnosed antemortem by endoretinal biopsy, and successfully treated with acyclovir and optic nerve fenestration [24].
• Correlation of the chemiluminescence-activity of peripheral blood monocytes with CSF parameters of inflammation and the clinical course of patients with lymphocytic meningoencephalitis [25].

Gene context of Meningoencephalitis

• Moreover, we show that a single immunization with the dominant T cell epitope Abeta10-24 induced transient meningoencephalitis only in amyloid precursor protein (APP)-transgenic (Tg) mice expressing limited amounts of IFN-gamma under an myelin basic protein (MBP) promoter [21].
• The presence of interleukin-8 (IL-8), a leukocyte chemotactic factor, was examined in primary and metastatic central nervous system tumors and in nonneoplastic acute meningoencephalitides [26].
• We used competitive reverse transcription-PCR to delineate the time course of the local expression of mRNAs encoding a variety of cytokines and inducible nitric oxide synthase (iNOS) during progressive murine cryptococcal meningoencephalitis and assessed the CNS inflammatory response using immunohistochemistry [27].
• Marked increase of matrix metalloproteinase 9 in cerebrospinal fluid of patients with fungal or tuberculous meningoencephalitis [28].
• No differences in numbers of blood MNC expressing MCP-1 or RANTES could be found in MS patients compared to healthy individuals or patients with acute aseptic meningoencephalitis (AM) [29].

Analytical, diagnostic and therapeutic context of Meningoencephalitis

• Bovine herpesvirus type 5 (BHV-5) is an alphaherpesvirus associated with meningoencephalitis, a disease highly prevalent in South America. In this study, we investigated the distribution of BHV-5 DNA in the brains of latently, experimentally infected calves by using a PCR for the glycoprotein B gene [30].
• A case of primary amebic meningoencephalitis. Light and electron microscopy, and immunohistologic studies [31].
• We report a case of meningoencephalitis with multiple abscess formation caused by MRSA, which occurred in a 4-year-old boy soon after allogeneic peripheral blood stem cell transplantation [32].
• SPECT scans for monitoring response to pleconaril therapy in chronic enteroviral meningoencephalitis [33].

References